The Nature and Prevalence of Depression in Chronic Schizophrenic In-patients

1989 ◽  
Vol 154 (4) ◽  
pp. 486-491 ◽  
Author(s):  
Thomas R. E. Barnes ◽  
David A. Curson ◽  
Peter F. Liddle ◽  
Meena Patel
Keyword(s):  
Tardive Dyskinesia ◽  
Depressed Mood ◽  
Negative Symptoms ◽  
Auditory Hallucinations ◽  
Anticholinergic Medication ◽  
Chronic Schizophrenic ◽  
Depressed Group ◽  
Prevalence Of Depression ◽  
Suicidal Ideas

Out of 194 chronic schizophrenic inpatients, depressed mood (item 23 of the PSE) was present in 25 (13%). When compared with 25 matched controls, the patients with depressed mood had significantly higher scores on the MADRS and the Beck Depression Inventory. Serious suicidal ideas and auditory hallucinations were significantly more common in the depressed group. However, there were no significant differences between the matched groups in terms of negative symptoms, Parkinsonism, tardive dyskinesia, anticholinergic medication, or current dose of antipsychotic drug, which suggests that the depression identified was not related to drug treatment, nor was it a direct manifestation or misinterpretation of negative symptoms. Over three-month follow-up, the MADRS and Beck scores covaried closely with the presence or absence of depressed mood. This depressive syndrome persisted over the three months in the majority of patients originally depressed.

The Psychological Consequences of Tardive Dyskinesia the Effect of Drug-Induced Parkinsonism and the Topography of the Dyskinetic Movements

1991 ◽  
Vol 159 (3) ◽  
pp. 399-403 ◽  
Author(s):  
Keith W. Brown ◽  
Thomas White
Keyword(s):  
Cognitive Impairment ◽  
Tardive Dyskinesia ◽  
Negative Symptoms ◽  
Anticholinergic Medication ◽  
Psychological Consequences ◽  
Confounding Variable ◽  
Drug Induced

The effect of drug-induced Parkinsonism and of the topography of the dyskinetic movements on the psychological consequences of tardive dyskinesia was assessed in 20 schizophrenic subjects and 20 non-dyskinetic schizophrenic controls matched for age, sex, the presence of anticholinergic medication, and the presence and severity of drug-induced Parkinsonism. Limb–truncal subscale scores but not orofacial scores had a significant correlation with cognitive impairment and with negative symptoms. Drug-induced Parkinsonism was found to be a powerful confounding variable.

Cognitive impairment and negative symptoms in geriatric chronic schizophrenic patients: a follow-up study

1996 ◽  
Vol 22 (3) ◽  
pp. 223-231 ◽  
Author(s):  
Philip D. Harvey ◽  
Janel Lombardi ◽  
Martin Leibman ◽  
Leonard White ◽  
Michael Parrella ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Negative Symptoms ◽  
Chronic Schizophrenic ◽  
Follow Up Study ◽  
Schizophrenic Patients

Correlation of Negative Symptoms in Schizophrenia with Frontal Lobe Parameters on Magnetic Resonance Imaging

1991 ◽  
Vol 159 (1) ◽  
pp. 130-134 ◽  
Author(s):  
P. Williamson ◽  
D. Pelz ◽  
H. Merskey ◽  
S. Morrison ◽  
P. Conlon
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tardive Dyskinesia ◽  
Frontal Lobe ◽  
Negative Symptoms ◽  
Positive Symptoms ◽  
Resonance Imaging ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients

Among 24 chronic schizophrenic patients, the 10 with high ratings for negative symptoms had significantly higher left-frontal: temporal–cortical T2 ratios. This finding was unrelated to age, dose of medication, length of illness or handedness. No T1 or T2 changes were found to be associated with positive symptoms or tardive dyskinesia in the regions examined.

Prevalence and clinical correlates of depression in the acute phase of first episode schizophrenia

2010 ◽  
Vol 27 (1) ◽  
pp. 15-18 ◽  
Author(s):  
Eric Roche ◽  
Mary Clarke ◽  
Stephen Browne ◽  
Niall Turner ◽  
Orflaith McTuige ◽  
...  
Keyword(s):  
Negative Symptoms ◽  
Depression Scale ◽  
First Episode ◽  
Syndrome Scale ◽  
Prevalence Of Depression ◽  
History Of ◽  
First Episode Schizophrenia ◽  
Negative Syndrome ◽  
First Episode Of Schizophrenia

AbstractBackground: Reported rates of depression in schizophrenia vary considerably.Objective: To measure the prevalence of depression in a first episode sample of people with schizophrenia.Methods: All referrals with a first episode of schizophrenia diagnosed using SCID interviews were assessed pre-discharge and again six months later. We used the Calgary Depression Scale for Schizophrenia (CDSS) and Positive and Negative Syndrome Scale (PANSS) to assess the severity of symptoms.Results: Pre-discharge, 10.4% of the sample met CDSS criteria for depression. According to the PANSS depression (PANSS -D) subscale, 3% of patients were depressed, with a mean score of 7.48 (SD = 2.97). Only 3% of patients pre-discharge were found to be depressed on both the CDSS and the PANSS-D. Six months later 6.5% were depressed according to the CDSS. However none reached depression criteria according to the PANSS-D. The CDSS correlated with PANSS-D both pre-discharge and at follow-up. Feelings of depression and self-deprecation were the most common symptoms at baseline and follow-up. The CDSS was unrelated to negative symptoms at both stages. A lifetime history of alcohol abuse increased the risk for depression.Conclusion: Rates of depression in this sample were low. The CDSS appears to discriminate between depression and negative symptoms. Like the general population, alcohol misuse is a risk factor for depression in first episode schizophrenia.

Tardive Dyskinesia: a Five Year Follow-Up*

1989 ◽  
Vol 34 (7) ◽  
pp. 700-703 ◽  
Author(s):  
X. Fornazzari ◽  
H. Grossman ◽  
J. Thornton ◽  
M.V. Seeman
Keyword(s):  
Tardive Dyskinesia ◽  
Outpatient Clinic ◽  
Attrition Rate ◽  
Prolonged Treatment ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients ◽  
High Attrition Rate

A group of chronic schizophrenic patients receiving prolonged treatment with neuroleptics was assessed in 1978 at an outpatient clinic to determine the prevalence of Tardive Dyskinesia. Those with TD were reassessed after two and five years with regard to change in TD severity. The Smith scale was used every time and, on the last assessment, the AIMS scale and videotaped interviews were added. Because of the high attrition rate, results, though interesting, cannot be generalized.

The Nithsdale Schizophrenia Survey V. Follow-up of Tardive Dyskinesia at3-1/2 years

1986 ◽  
Vol 149 (5) ◽  
pp. 621-623 ◽  
Author(s):  
A. D. T. Robinson ◽  
R. G. McCreadie
Keyword(s):  
Tardive Dyskinesia ◽  
Older Patients ◽  
Geographical Area ◽  
Point Prevalence ◽  
Abnormal Involuntary Movements ◽  
Involuntary Movements ◽  
Transient Feature

The point-prevalence of tardive dyskinesia in schizophrenics from a discrete geographical area (Nithsdale, in Dumfries and Galloway Region) in 1981, 1982, and 1984 was 31%, 27%, and 30% respectively. This suggests that the prevalence of tardive dyskinesia in a community of schizophrenics has reached a plateau. In 12% of patients there was persistent dyskinesia, i.e. abnormal involuntary movements were present at all three assessments. Persistent dyskinesia was more common in older patients. The severity of tardive dyskinesia fluctuated between assessments in 41 % of patients, indicating that it is only a transient feature in some cases.

scholarly journals Patterns and predictors of hospitalisation in first-episode psychosis

2001 ◽  
Vol 178 (6) ◽  
pp. 518-523 ◽  
Author(s):  
Attila Sipos ◽  
Glynn Harrison ◽  
David Gunnell ◽  
Shazad Amin ◽  
Swaran P. Singh
Keyword(s):  
Negative Symptoms ◽  
First Episode Psychosis ◽  
Psychiatric Services ◽  
First Episode ◽  
Psychotic Episode ◽  
Duration Of Untreated Illness ◽  
Specialist Services ◽  
Increased Risk ◽  
Episode Psychosis

BackgroundLittle is known about predictors of hospitalisation in patients with first-episode psychosis.AimsTo identify the pattern and predictors of hospitalisation of patients with a first psychotic episode making their first contact with specialist services.MethodThree-year follow-up of a cohort of 166 patients with a first episode of psychosis making contact with psychiatric services in Nottingham between June 1992 and May 1994.ResultsEighty-eight (53.0%) patients were admitted within 1 week of presentation; 32 (19.3%) were never admitted during the 3 years of follow-up. Manic symptoms at presentation were associated with an increased risk of rapid admission and an increased overall risk of admission; negative symptoms and a longer duration of untreated illness had an increased risk of late admission.ConclusionsCommunity-oriented psychiatric services might only delay, rather than prevent, admission of patients with predominantly negative symptoms and a longer duration of untreated illness. First-episode studies based upon first admissions are likely to be subject to selection biases, which may limit their representativeness.

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