P300 and CT Scan in Patients with Chronic Schizophrenia

1987 ◽  
Vol 151 (4) ◽  
pp. 506-513 ◽  
Author(s):  
A. Romani ◽  
S. Merello ◽  
L. Gozzoli ◽  
F. Zerbi ◽  
M. Grassi ◽  
...  

Twenty chronic male schizophrenic subjects aged 30–50 years were examined by an auditory event-related potential procedure for the evaluation of the P300 component, a CT scan and a neuropsychological test battery. The P300 latency was increased and its amplitude was reduced. CT scan measures showed lateral and third ventricle enlargement, and there was a global neuropsychological impairment. Poor neuropsychological performances were consistently associated with delayed P300 latencies, but not with CT scan measures. Ventricular enlargement was more pronounced among subjects with a negative family history for major psychiatric disorders.

Author(s):  
Elena V. Krivonogova ◽  

Living in adverse climatic and geographical conditions of the Arctic zone of the Russian Federation requires mobilization of the adaptive mechanisms of the central nervous system in humans. The parameters of the event-related potential P300 serve as indicators of brain bioelectric processes associated with the mechanisms of information perception and processing. This study aimed to establish the parameters of the event-related potential P300 in 16–17-year-old schoolchildren living in different regions of the Arctic zone of the Russian Federation based on a comparative analysis. The auditory event-related potential P300 was evaluated in subjects living in the Nenets Autonomus Okrug (NAO), Yamalo-Nenets Autonomous Okrug (YNAO) and the Arkhangelsk Region (AR). P300 latency and amplitude were recorded by the Encephalan-131-03 electroencephalograph (Medicom MTD, Russia) in the frontal (F3, F4), central (C4, C3), parietal (P3, P4), mid-temporal (T3, T4), and anterior temporal (F7, F8) areas of the brain using the oddball method. In schoolchildren living in AR and YNAO, the amplitude-latency parameters of P300 did not differ significantly. Subjects living in NAO, the majority of whom are representatives of the indigenous peoples of the North (the Nenets), had a longer P300 latency than their peers from other regions. Р300 amplitudes in schoolchildren from all the regions under study were statistically identical. The author comes to the conclusion that longer information processing time, according to the P300 data, reflects the adaptive psychophysiological characteristics of the population with a long historical experience of living in the North.


2002 ◽  
Vol 16 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Antoinette R. Miller ◽  
J. Peter Rosenfeld ◽  
Matthew Soskins ◽  
Marianne Jhee

Abstract The P300 component of the event-related potential was recorded during two blocks of an autobiographical oddball task. All participants performed honestly during the first block (Phone), i.e., the oddball stimuli were phone numbers. During the second block (Birthday), in which the oddball stimuli were participants' birthdays, a Truth group (N = 13) performed honestly and a Malinger group (N = 14) simulated amnesia. Amnesia simulation significantly reduced P300 amplitudes, both between groups and within the Malinger group (Phone vs. Birthday), possibly because of an increase in task difficulty in the Malinger condition. Analysis of scaled amplitudes also indicated a trend for a feigning-related alteration in P300 topography. Bootstrapping of peak-to-peak amplitudes detected significantly more (93%) Malinger individuals than bootstrapping of baseline-to-peak amplitudes (64%). Bootstrapping also provided evidence of a feigning-related amplitude difference between oddball stimuli (i.e., Phone > Birthday) in 71% of Malinger group individuals. In this comparison, the peak-to-peak measure also performed significantly better in intraindividual diagnostics.


2004 ◽  
Vol 18 (1) ◽  
pp. 13-26 ◽  
Author(s):  
Antoinette R. Miller ◽  
J. Peter Rosenfeld

Abstract University students were screened using items from the Psychopathic Personality Inventory and divided into high (n = 13) and low (n = 11) Psychopathic Personality Trait (PPT) groups. The P300 component of the event-related potential (ERP) was recorded as each group completed a two-block autobiographical oddball task, responding honestly during the first (Phone) block, in which oddball items were participants' home phone numbers, and then feigning amnesia in response to approximately 50% of items in the second (Birthday) block in which oddball items were participants' birthdates. Bootstrapping of peak-to-peak amplitudes correctly identified 100% of low PPT and 92% of high PPT participants as having intact recognition. Both groups demonstrated malingering-related P300 amplitude reduction. For the first time, P300 amplitude and topography differences were observed between honest and deceptive responses to Birthday items. No main between-group P300 effects resulted. Post-hoc analysis revealed between-group differences in a frontally located post-P300 component. Honest responses were associated with late frontal amplitudes larger than deceptive responses at frontal sites in the low PPT group only.


2019 ◽  
Vol 33 (8) ◽  
pp. 1136-1150
Author(s):  
Nathalie Bedoin ◽  
Raphaëlle Abadie ◽  
Jennifer Krzonowski ◽  
Emmanuel Ferragne ◽  
Agathe Marcastel

2021 ◽  
Vol 11 (1) ◽  
pp. 39
Author(s):  
Álvaro Fernández-Rodríguez ◽  
Ricardo Ron-Angevin ◽  
Ernesto J. Sanz-Arigita ◽  
Antoine Parize ◽  
Juliette Esquirol ◽  
...  

Studies so far have analyzed the effect of distractor stimuli in different types of brain–computer interface (BCI). However, the effect of a background speech has not been studied using an auditory event-related potential (ERP-BCI), a convenient option when the visual path cannot be adopted by users. Thus, the aim of the present work is to examine the impact of a background speech on selection performance and user workload in auditory BCI systems. Eleven participants tested three conditions: (i) auditory BCI control condition, (ii) auditory BCI with a background speech to ignore (non-attentional condition), and (iii) auditory BCI while the user has to pay attention to the background speech (attentional condition). The results demonstrated that, despite no significant differences in performance, shared attention to auditory BCI and background speech required a higher cognitive workload. In addition, the P300 target stimuli in the non-attentional condition were significantly higher than those in the attentional condition for several channels. The non-attentional condition was the only condition that showed significant differences in the amplitude of the P300 between target and non-target stimuli. The present study indicates that background speech, especially when it is attended to, is an important interference that should be avoided while using an auditory BCI.


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