Haloperidol-Induced Changes in Blink Rates Correlate with Changes in BPRS Score

1982 ◽  
Vol 140 (5) ◽  
pp. 503-507 ◽  
Author(s):  
Craig N. Karson ◽  
Llewellyn B. Bigelow ◽  
Joel E. Kleinman ◽  
Daniel R. Weinberger ◽  
Richard Jed Wyatt
Keyword(s):  
Psychiatric Symptoms ◽  
Blocking Agent ◽  
Positive Symptoms ◽  
Cerebral Ventricles ◽  
Eye Blink ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients ◽  
Thought Disturbance ◽  
Induced Changes ◽  
The Relationship

SummarySpontaneous eye blink rates, psychiatric symptoms and response to neuroleptic medication may all be mediated by dopamine. Fixed doses of haloperidol, a dopamine blocking agent, were administered for six weeks to 17 chronic schizophrenic patients who had been previously withdrawn from all medications. The change in blink rates caused by haloperidol corresponded to a change in the thought disturbance syndrome which measures positive symptoms (r =.48, P <.05). The relationship was particularly clear in patients with normal cerebral ventricles (r =.74, P <.01).

The Empirical Heterogeneity of First Rank Symptoms in Schizophrenia

1982 ◽  
Vol 140 (5) ◽  
pp. 498-502 ◽  
Author(s):  
Richard Lewine ◽  
Robin Renders ◽  
Mark Kirchhofer ◽  
Ann Monsour ◽  
Norman Watt
Keyword(s):  
Psychiatric Symptoms ◽  
Empirical Studies ◽  
Reliability And Validity ◽  
Homogeneous Group ◽  
Schizophrenic Patients ◽  
First Rank Symptoms ◽  
The Relationship

SummaryFirst rank symptoms have assumed an important role in the assessment of schizophrenia. Only recently, however, have there been empirical studies of their reliability and validity. In this study, we examined the relationship between first rank and other psychiatric symptoms in 100 schizophrenic patients. The results are consistent with other research reports suggesting that first rank symptoms do not represent a homogeneous group of symptoms within an individual patient.

Family History of Schizophrenia and the Relationship of Stress to Symptoms: Preliminary Findings

2001 ◽  
Vol 35 (2) ◽  
pp. 217-223 ◽  
Author(s):  
Ross M. G. Norman ◽  
Ashok K. Malla
Keyword(s):  
Family History ◽  
Negative Affect ◽  
Negative Symptoms ◽  
Positive Family History ◽  
Positive Symptoms ◽  
Daily Stressors ◽  
Schizophrenic Patients ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

Objective: It has been hypothesized that patients with a diagnosis of schizophrenia who have a positive family history for schizophrenia will show greater reactivity of their symptoms to increasing levels of stress or negative affect than will patients without such a family history. In the past this hypothesis has only been tested through manipulations of negative affect in laboratory settings. In this paper we test this hypothesis using longitudinal clinical data. Method: Data were derived from an earlier longitudinal study using monthly assessments of daily stressors (Hassles Scale) and symptom measures (the Scale for the Assessment of Positive Symptoms and the Scale for the Assessment of Negative Symptoms). We compared longitudinal stress to symptom relations in 12 patients with schizophrenia for whom a positive family history of schizophrenia could be identified with 12 matched schizophrenic patients without any known family history of psychiatric illness. Results: There was evidence that patients with a family history of schizophrenia demonstrated a stronger relation between stress and total score on the Scale for the Assessment of Positive Symptoms. This difference appears to have primarily reflected a greater reactivity to stress of reality distortion symptoms in the positive family history group. The two groups did not differ in apparent reactivity to stress of the disorganization and psychomotor poverty dimensions of symptomatology. Conclusions: The results of this study provide support from a naturalistic, longitudinal clinical study for the hypothesis that reactivity to stress of some symptoms of schizophrenia may vary as a function of family history of the disorder.

Religiosity, Schizotypal Thinking, and Schizophrenia

1989 ◽  
Vol 65 (2) ◽  
pp. 587-593 ◽  
Author(s):  
Joan Feldman ◽  
John Rust
Keyword(s):  
Religious Belief ◽  
Normal Development ◽  
Negative Relationship ◽  
Normal Subjects ◽  
Normal Sample ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients ◽  
The Relationship

The relationship between religiosity and the incidence of schizotypal thinking was investigated in a normal sample and in acute and chronic schizophrenic samples. The Rust Inventory of Schizotypal Cognitions was administered to measure schizotypal thinking, and two religiosity measures were developed. Religiosity had a significantly negative relationship with schizotypal thinking in normal subjects, while in schizophrenic patients the relationship was positive and significantly different. It is suggested that the process of existential growth of awareness in the normal development of religious belief, which is thought to be associated with schizotypal thinking, may have proceeded differently in persons suffering from schizophrenia.

Two kinds of cognitive deficit associated with chronic schizophrenia

1977 ◽  
Vol 7 (1) ◽  
pp. 171-173 ◽  
Author(s):  
C. D. Frith
Keyword(s):  
Feature Selection ◽  
Negative Symptoms ◽  
Cognitive Deficit ◽  
Chronic Schizophrenia ◽  
Positive Symptoms ◽  
Chronic Schizophrenic ◽  
Normal Degree ◽  
Schizophrenic Patients

SynopsisThe performance of 21 chronic schizophrenic patients was investigated on two tests of feature selection. It was found that patients with negative symptoms (muteness, withdrawal, etc.) were characterized by an extreme lack of persistence, but selected usual features; whereas patients with positive symptoms (hallucinations, delusions, etc.) had a normal degree of persistence, but selected unusual features.

Patient Psychopathology and Expressed Emotion in Schizophrenia

1990 ◽  
Vol 157 (6) ◽  
pp. 877-880 ◽  
Author(s):  
Shirley M. Glynn ◽  
Eugenia T. Randolph ◽  
Spencer Eth ◽  
George G. Paz ◽  
Gregory B. Leong ◽  
...  
Keyword(s):  
Schizoaffective Disorder ◽  
Negative Symptoms ◽  
Expressed Emotion ◽  
Psychiatric Symptoms ◽  
Full Range ◽  
Positive Symptoms ◽  
Anxious Depression ◽  
Relationship Of ◽  
The Relationship

The relationship of a full range of psychiatric symptoms to EE was examined in 40 men with BPRS and SANS diagnoses of schizophrenia or schizoaffective disorder. Patients from high-EE families had significantly higher ratings of positive symptoms, anxious depression, and overall psychopathology, but not negative symptoms, than did those from low-EE families. In predicting relapses of schizophrenia, account may need to be taken of an interaction between subtle differences in symptoms and relatives' attitudes.

Problems of patients with schizophrenic disorders and of their families

1999 ◽  
Vol 8 (2) ◽  
pp. 117-130 ◽  
Author(s):  
Dino Lanzara ◽  
Ugo Cosentino ◽  
Anna Maria Lo Maglio ◽  
Antonio Lora ◽  
Anna Nicolo ◽  
...  
Keyword(s):  
Mental Health ◽  
Negative Symptoms ◽  
Psychiatric Symptoms ◽  
Principal Component ◽  
Family Burden ◽  
Positive Symptoms ◽  
Explanatory Variables ◽  
Service Information ◽  
Icd 10 ◽  
Schizophrenic Patients

SummaryObjective — To evaluate psychopathological symptoms, disabilities and family burden in schizophrenic patients and to analyse predictors of family burden and relatives' satisfaction. Design — Descriptive study of 203 patients with an ICD 10 — F2 diagnosis (schizophrenia and related disorders) in contact with the Desio Department of Mental Health on 31st December 1994. Setting — The Desio Department of Mental Health. Main outcome measures — The patients have been evaluated in three areas: disability (by ADC-DAS), psychiatric symptoms (by 24 items BPRS) and family burden (by Family Problems questionnaire). The outpatient, hospital and residential care contacts of the patients have been collected for six months by our service information system. For each area (DAS, BPRS and FP) a principal component analysis and a rotation of the significant components have been performed. Eleven factors, derived from three scales, have been retained as explanatory variables. Finally, a multiple regression analysis has been performed to assess the influence of explanatory variables on the set of response variables regarding family burden and relatives' satisfaction. Results — One third of patients suffer of moderate-severe positive symptoms, while negative symptoms are less frequent.

Schizophrenia and coeliac disease – the nature of the relationship

1977 ◽  
Vol 7 (2) ◽  
pp. 259-263 ◽  
Author(s):  
F. M. Stevens ◽  
R. S. Lloyd ◽  
S. M. J. Geraghty ◽  
M. T. G. Reynolds ◽  
M. J. Sarsfield ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Genetic Relationship ◽  
Mucosal Biopsy ◽  
The West ◽  
Histological Features ◽  
Chronic Schizophrenic ◽  
Mental Hospitals ◽  
Schizophrenic Patients ◽  
The Relationship ◽  
West Of Ireland

synopsisTo test the hypothesis of an association between schizophrenia and coeliac disease, the sera of 380 chronic schizophrenic in-patients in two mental hospitals in the West of Ireland have been screened for the presence of reticulin antibodies. Antibodies were found in 26 patients. Twenty-one of these patients were further studied by proximal duodenal mucosal biopsy. None of the biopsies showed the morphological and histological features found in untreated coeliac disease. The incidence of reticulin antibodies in schizophrenic patients and controls is similar. The findings of this study lead to the rejection of the hypothesis of a positive genetic relationship between schizophrenia and coeliac disease.

Correlation of Negative Symptoms in Schizophrenia with Frontal Lobe Parameters on Magnetic Resonance Imaging

1991 ◽  
Vol 159 (1) ◽  
pp. 130-134 ◽  
Author(s):  
P. Williamson ◽  
D. Pelz ◽  
H. Merskey ◽  
S. Morrison ◽  
P. Conlon
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tardive Dyskinesia ◽  
Frontal Lobe ◽  
Negative Symptoms ◽  
Positive Symptoms ◽  
Resonance Imaging ◽  
Chronic Schizophrenic ◽  
Schizophrenic Patients

Among 24 chronic schizophrenic patients, the 10 with high ratings for negative symptoms had significantly higher left-frontal: temporal–cortical T2 ratios. This finding was unrelated to age, dose of medication, length of illness or handedness. No T1 or T2 changes were found to be associated with positive symptoms or tardive dyskinesia in the regions examined.

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