scholarly journals NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp

2013 ◽  
Vol 95 (3) ◽  
pp. 487-495 ◽  
Author(s):  
Esther Serrano-Pertierra ◽  
Eva Cernuda-Morollón ◽  
Carlos López-Larrea
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Chemotaxis

scholarly journals On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients

2004 ◽  
Vol 10 (14) ◽  
pp. 4754-4760 ◽  
Author(s):  
Monique van Oijen ◽  
Adriaan Bins ◽  
Sjoerd Elias ◽  
Johan Sein ◽  
Pauline Weder ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Cd8 T Cell ◽  
T Cell Immunity ◽  
Advanced Stage ◽  
Cell Immunity ◽  
Melanoma Patients

scholarly journals Essential Role of CD11a in CD8 + T-Cell Accumulation and Activation in Adipose Tissue

2014 ◽  
Vol 34 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Erlie Jiang ◽  
Xiaoyuan Dai Perrard ◽  
Donglin Yang ◽  
Ilvira M. Khan ◽  
Jerry L. Perrard ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
T Cell ◽  
Essential Role ◽  
Cd8 T Cell ◽  
Cell Accumulation

P2-004: The role of CD8 T cell and its receptor change in Alzheimer's disease

2012 ◽  
Vol 8 (4S_Part_7) ◽  
pp. P265-P265
Author(s):  
Chuanhai Cao ◽  
Xiaoyang Lin ◽  
Wenshi Wang ◽  
Yaqiong Li ◽  
Jianfeng Cai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
T Cell ◽  
Cd8 T Cell

scholarly journals Immunological Profile of Heterosexual Highly HIV‐Exposed Uninfected Individuals: Predominant Role of CD4 and CD8 T‐Cell Activation

2007 ◽  
Vol 196 (8) ◽  
pp. 1191-1201 ◽  
Author(s):  
Anna Suy ◽  
Pedro Castro ◽  
Meritxell Nomdedeu ◽  
Felipe García ◽  
Anna López ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Predominant Role ◽  
Immunological Profile ◽  
Hiv Exposed ◽  
Exposed Uninfected

scholarly journals Role of PD-1 during effector CD8 T cell differentiation

2018 ◽  
Vol 115 (18) ◽  
pp. 4749-4754 ◽  
Author(s):  
Eunseon Ahn ◽  
Koichi Araki ◽  
Masao Hashimoto ◽  
Weiyan Li ◽  
James L. Riley ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Differentiation ◽  
T Cell ◽  
Viral Infection ◽  
Cd8 T Cells ◽  
Cell Epitope ◽  
Cd8 T Cell ◽  
T Cell Differentiation ◽  
Lcmv Infection

PD-1 (programmed cell death-1) is the central inhibitory receptor regulating CD8 T cell exhaustion during chronic viral infection and cancer. Interestingly, PD-1 is also expressed transiently by activated CD8 T cells during acute viral infection, but the role of PD-1 in modulating T cell effector differentiation and function is not well defined. To address this question, we examined the expression kinetics and role of PD-1 during acute lymphocytic choriomeningitis virus (LCMV) infection of mice. PD-1 was rapidly up-regulated in vivo upon activation of naive virus-specific CD8 T cells within 24 h after LCMV infection and in less than 4 h after peptide injection, well before any cell division had occurred. This rapid PD-1 expression by CD8 T cells was driven predominantly by antigen receptor signaling since infection with a LCMV strain with a mutation in the CD8 T cell epitope did not result in the increase of PD-1 on antigen-specific CD8 T cells. Blockade of the PD-1 pathway using anti–PD-L1 or anti–PD-1 antibodies during the early phase of acute LCMV infection increased mTOR signaling and granzyme B expression in virus-specific CD8 T cells and resulted in faster clearance of the infection. These results show that PD-1 plays an inhibitory role during the naive-to-effector CD8 T cell transition and that the PD-1 pathway can also be modulated at this stage of T cell differentiation. These findings have implications for developing therapeutic vaccination strategies in combination with PD-1 blockade.

Role of CD8 T-cell in immune response to tuberculosis-specific antigen in QuantiFERON-TB Gold Plus

2020 ◽  
Vol 26 (6) ◽  
pp. 570-574
Author(s):  
Mizue Tsuyuzaki ◽  
Hidetoshi Igari ◽  
Nao Okada ◽  
Kiminori Suzuki
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Specific Antigen ◽  
Cd8 T Cell
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