scholarly journals Immunological Profile of Heterosexual Highly HIV‐Exposed Uninfected Individuals: Predominant Role of CD4 and CD8 T‐Cell Activation

2007 ◽  
Vol 196 (8) ◽  
pp. 1191-1201 ◽  
Author(s):  
Anna Suy ◽  
Pedro Castro ◽  
Meritxell Nomdedeu ◽  
Felipe García ◽  
Anna López ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Predominant Role ◽  
Immunological Profile ◽  
Hiv Exposed ◽  
Exposed Uninfected

scholarly journals Cytomegalovirus viraemia is associated with poor growth and T-cell activation with an increased burden in HIV-exposed uninfected infants

AIDS ◽  
2017 ◽  
Vol 31 (13) ◽  
pp. 1809-1818 ◽  
Author(s):  
Miguel A. Garcia-Knight ◽  
Eunice Nduati ◽  
Amin S. Hassan ◽  
Irene Nkumama ◽  
Timothy J. Etyang ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Poor Growth ◽  
Hiv Exposed ◽  
Exposed Uninfected

scholarly journals Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells

2021 ◽  
Vol 218 (7) ◽  
Author(s):  
Miwa Sasai ◽  
Ji Su Ma ◽  
Masaaki Okamoto ◽  
Kohei Nishino ◽  
Hikaru Nagaoka ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Cell Receptor ◽  
Tcr Signaling

Because of their common signaling molecules, the main T cell receptor (TCR) signaling cascades in CD4+ and CD8+ T cells are considered qualitatively identical. Herein, we show that TCR signaling in CD8+ T cells is qualitatively different from that in CD4+ T cells, since CD8α ignites another cardinal signaling cascade involving phospholipase C β4 (PLCβ4). TCR-mediated responses were severely impaired in PLCβ4-deficient CD8+ T cells, whereas those in CD4+ T cells were intact. PLCβ4-deficient CD8+ T cells showed perturbed activation of peripheral TCR signaling pathways downstream of IP3 generation. Binding of PLCβ4 to the cytoplasmic tail of CD8α was important for CD8+ T cell activation. Furthermore, GNAQ interacted with PLCβ4, mediated double phosphorylation on threonine 886 and serine 890 positions of PLCβ4, and activated CD8+ T cells in a PLCβ4-dependent fashion. PLCβ4-deficient mice exhibited defective antiparasitic host defense and antitumor immune responses. Altogether, PLCβ4 differentiates TCR signaling in CD4+ and CD8+ T cells and selectively promotes CD8+ T cell–dependent adaptive immunity.

Role of CD8 + T cell activation status in determining susceptibility to tumor‐induced immune suppression

2008 ◽  
Vol 22 (S2) ◽  
pp. 524-524
Author(s):  
Jeremy A O'Sullivan ◽  
James McCracken ◽  
Gretchen Lyons ◽  
Jose A Guevara‐Patino
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Immune Suppression ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Activation Status

Essential role of PD-1/PD-L1 pathway to regulate CD8+ T-cell activation in murine contact hypersensitivity

2017 ◽  
Vol 86 (2) ◽  
pp. e64
Author(s):  
Tomoko Hirano ◽  
Tetsuya Honda ◽  
Koji Tamada ◽  
Lieping Chen ◽  
Kenji Kabashima
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Essential Role ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Contact Hypersensitivity

scholarly journals CD8+ T Cells in Atherosclerosis

Cells ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 37
Author(s):  
Sarah Schäfer ◽  
Alma Zernecke
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cd8 T Cells ◽  
Cell Activation ◽  
Critical Role ◽  
Cd8 T Cell ◽  
Immune Checkpoints ◽  
Cell Functions

Atherosclerotic lesions are populated by cells of the innate and adaptive immune system, including CD8+ T cells. The CD8+ T cell infiltrate has recently been characterized in mouse and human atherosclerosis and revealed activated, cytotoxic, and possibly dysfunctional and exhausted cell phenotypes. In mouse models of atherosclerosis, antibody-mediated depletion of CD8+ T cells ameliorates atherosclerosis. CD8+ T cells control monopoiesis and macrophage accumulation in early atherosclerosis. In addition, CD8+ T cells exert cytotoxic functions in atherosclerotic plaques and contribute to macrophage cell death and necrotic core formation. CD8+ T cell activation may be antigen-specific, and epitopes of atherosclerosis-relevant antigens may be targets of CD8+ T cells and their cytotoxic activity. CD8+ T cell functions are tightly controlled by costimulatory and coinhibitory immune checkpoints. Subsets of regulatory CD25+CD8+ T cells with immunosuppressive functions can inhibit atherosclerosis. Importantly, local cytotoxic CD8+ T cell responses may trigger endothelial damage and plaque erosion in acute coronary syndromes. Understanding the complex role of CD8+ T cells in atherosclerosis may pave the way for defining novel treatment approaches in atherosclerosis. In this review article, we discuss these aspects, highlighting the emerging and critical role of CD8+ T cells in atherosclerosis.

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