scholarly journals Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study

Critical Care ◽  
2010 ◽  
Vol 14 (6) ◽  
pp. R205 ◽  
Author(s):  
Sari Karlsson ◽  
Milja Heikkinen ◽  
Ville Pettila ◽  
Seija Alila ◽  
Sari Vaisanen ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Observational Study ◽  
Predictive Value ◽  
Prospective Observational Study

Predictive value of thyroxine for prognosis in pediatric septic shock: a prospective observational study

2020 ◽  
Vol 33 (5) ◽  
pp. 653-659
Author(s):  
Jia Song ◽  
Yun Cui ◽  
Chunxia Wang ◽  
Jiaying Dou ◽  
Huijie Miao ◽  
...  
Keyword(s):  
Septic Shock ◽  
Thyroid Hormone ◽  
Observational Study ◽  
Hospital Mortality ◽  
Predictive Value ◽  
Prospective Observational Study ◽  
Threshold Value ◽  
Nonthyroidal Illness ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

AbstractBackgroundThyroid hormone plays an important role in the adaptation of metabolic function to critically ill. The relationship between thyroid hormone levels and the outcomes of septic shock is still unclear. The aim of this study was to assess the predictive value of thyroid hormone for prognosis in pediatric septic shock.MethodsWe performed a prospective observational study in a pediatric intensive care unit (PICU). Patients with septic shock were enrolled from August 2017 to July 2019. Clinical and laboratory indexes were collected, and thyroid hormone levels were measured on PICU admission.ResultsNinety-three patients who fulfilled the inclusion criteria were enrolled in this study. The incidence of nonthyroidal illness syndrome (NTIS) was 87.09% (81/93) in patients with septic shock. Multivariate logistic regression analysis showed that T4 level was independently associated with in-hospital mortality in patients with septic shock (OR: 0.965, 95% CI: 0.937–0.993, p = 0.017). The area under receiver operating characteristic (ROC) curve (AUC) for T4 was 0.762 (95% CI: 0.655–0.869). The cutoff threshold value of 58.71 nmol/L for T4 offered a sensitivity of 61.54% and a specificity of 85.07%, and patients with T4 < 58.71 nmol/L showed high mortality (60.0%). Moreover, T4 levels were negatively associated with the pediatric risk of mortality III scores (PRISM III), lactate (Lac) level in septic shock children.ConclusionsNonthyroidal illness syndrome is common in pediatric septic shock. T4 is an independent predictor for in-hospital mortality, and patients with T4 < 58.71 nmol/L on PICU admission could be with a risk of hospital mortality.

scholarly journals Prognostic Factors of Community-acquired Bacteremic Patients with Severe sepsis: A Prospective, Observational Study

2012 ◽  
Vol 44 (3) ◽  
pp. 168 ◽  
Author(s):  
Young Kyung Yoon ◽  
Min Ja Kim ◽  
Dae Won Park ◽  
Soon Sun Kwon ◽  
Byung Chul Chun ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Prognostic Factors ◽  
Observational Study ◽  
Prospective Observational Study

360 Predictive Value of Clinical Assessment of Severe Frostbite Injury - Preliminary Outcomes from a Prospective Observational Study

2018 ◽  
Vol 39 (suppl_1) ◽  
pp. S150-S150
Author(s):  
A M Lacey ◽  
J C Moore ◽  
A B Whitley ◽  
G Punjabi ◽  
T Masters ◽  
...  
Keyword(s):  
Observational Study ◽  
Clinical Assessment ◽  
Predictive Value ◽  
Prospective Observational Study

scholarly journals Superior Predictive Value for NTproBNP Compared with High Sensitivity cTnT in Dialysis Patients: A Pilot Prospective Observational Study

2014 ◽  
Vol 39 (6) ◽  
pp. 636-647 ◽  
Author(s):  
Luminita Voroneanu ◽  
Dimitrie Siriopol ◽  
Ionut Nistor ◽  
Mugurel Apetrii ◽  
Simona Hogas ◽  
...  
Keyword(s):  
Observational Study ◽  
Predictive Value ◽  
Prospective Observational Study ◽  
High Sensitivity ◽  
Dialysis Patients

scholarly journals Utility of pleural fluid adenosine deaminase in diagnosing tubercular pleural effusion: a prospective observational study in a tertiary care hospital

2019 ◽  
Vol 6 (6) ◽  
pp. 1711
Author(s):  
Gayathri Devi H. J. ◽  
Sujith H.
Keyword(s):  
Pleural Effusion ◽  
Observational Study ◽  
Pleural Fluid ◽  
Predictive Value ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical History ◽  
Diagnostic Methods ◽  
Care Hospital

Background: The diagnosis of Tubercular (TB) pleural effusion continues to be a challenge in clinical practice, as traditional diagnostic methods are useful but do not provide enough sensitivity and specificity.Methods: This was a prospective observational study carried out at Tertiary care Hospital with study population of 76 patients. Etiological diagnosis was based on clinical history with radiological imaging, biochemical and cytological examination of pleural fluid. Pleural fluid ADA was used as a biomarker for the diagnosis of tubercular pleural effusion.Results: The study included 76 patients with 69.7% (n=53) males and 30.3%(n=23) females. The mean age of patients was 48.97 17.03 years. Of 76 cases of pleural effusion, 62 were exudates and 14 transudates. Tuberculosis was the most common cause among exudates which accounted for 51.3% (n=39) of cases. The sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV), Accuracy of pleural fluid ADA in diagnosing tubercular pleural effusion was 92.3%, 97.3%, 97%, 92% and 94.7% respectively.Conclusions: Pleural fluid ADA can be one of the most reliable biomarkers for the diagnosis of TB pleural effusion considering its high sensitivity and specificity.

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