scholarly journals Prognostic Factors of Community-acquired Bacteremic Patients with Severe sepsis: A Prospective, Observational Study

2012 ◽  
Vol 44 (3) ◽  
pp. 168 ◽  
Author(s):  
Young Kyung Yoon ◽  
Min Ja Kim ◽  
Dae Won Park ◽  
Soon Sun Kwon ◽  
Byung Chul Chun ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Prognostic Factors ◽  
Observational Study ◽  
Prospective Observational Study

scholarly journals A prospective observational study on trajectories and prognostic factors of mid back pain

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Christina Knecht ◽  
Sonja Hartnack ◽  
Beate Sick ◽  
Fabienne Riner ◽  
Petra Schweinhardt ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Back Pain ◽  
Observational Study ◽  
Prospective Observational Study

Neoadjuvant Conformal Chemoradiation with Induction Chemotherapy for Rectal Adenocarcinoma. A Prospective Observational Study

2014 ◽  
Vol 23 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Zsolt Fekete ◽  
Alina-Simona Muntean ◽  
Stefan Hica ◽  
Alin Rancea ◽  
Liliana Resiga ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Anal Verge ◽  
Locally Advanced ◽  
Rectal Adenocarcinoma ◽  
Complete Response ◽  
Neoadjuvant Chemoradiation ◽  
Initial Tumor ◽  
Initial Tumor Size

Background & Aims: The purpose of this prospective observational study was to evaluate the rate andthe prognostic factors for down-staging and complete response for rectal adenocarcinoma after inductionchemotherapy and neoadjuvant chemoradiation followed by surgery, and to analyze the rate of sphinctersaving surgery.Methods: We included from March 2011 to October 2013 a number of 88 patients hospitalized with locally advanced rectal adenocarcinoma in the Prof. Dr. Ion Chiricuta Institute of Oncology, Cluj. The treatment schedule included 2-4 cycles of Oxaliplatin plus a fluoropyrimidine followed by concomitant chemoradiation with a dose of 50 Gy in 25 fractions combined with a fluoropyrimidine monotherapy.Results:The rate of T down-staging was 49.4% (40/81 evaluable patients). Independent prognostic factors for T down-staging were: age >57 years (p<0.01), cN0 (p<0.01), distance from anal verge >5 cm (p<0.01), initial CEA <6.2 ng/ml (p<0.01), higher number of chemotherapy cycles with Oxaliplatin (pROC=0.05) and protraction of radiotherapy of >35 days (p<0.01). Nine patients from 81 (11.1%) presented complete response (7 pathological and 2 clinical); the independent prognostic factors were stage cT2 versus cT3-4 (p<0.01), initial tumor size ≤3.5 cm and distance from anal verge >5 cm (p=0.03). Sixty-eight patients (79.1%) underwent radical surgery and among them 35 patients (51.5 %) had a sphincter saving procedure.Conclusions: Induction chemotherapy with neoadjuvant chemoradiation produced important down-staging in rectal adenocarcinoma. Independent prognostic factors for T down-staging were: age, cN0, distance from anal verge, initial CEA, the number of Oxaliplatin cycles and duration of radiotherapy; for complete response: cT2, initial tumor size and distance from the anal verge. Abbreviations: 5FU: 5-fluorouracil; AJCC: American Joint Committee on Cancer; AV: anal verge; CAPOX: Capecitabine plus Oxaliplatin; CCR: clinical complete response; CRT: chemoradiation; CTC4.0: Common Terminology Criteria for Adverse Events, version 4.0; ECOG: Eastern Collaborative Oncology Group; EUS: endorectal ultrasound; FOLFOX: 5-fluorouracil plus Oxaliplatin; LARC: locally advanced rectal cancer; PCR: pathological complete response; PS: performance status; PTV: planning target volume; R0: Resection, 0 (microscopically clear resection margin); ROC curve: receiver operating characteristic curve; TME: total mesorectal excision; TRG: tumor regression grade.

scholarly journals 1662P Outcomes and prognostic factors in localized soft tissue sarcoma: Prospective observational study

2020 ◽  
Vol 31 ◽  
pp. S989
Author(s):  
M.S. Shivashankara ◽  
S. Viswanath ◽  
S. Pandalanghat ◽  
A.N. Patel ◽  
B. Guleria ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Observational Study ◽  
Prospective Observational Study
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