scholarly journals Urine interleukin-6 is an early biomarker of acute kidney injury in children undergoing cardiac surgery

Critical Care ◽  
2010 ◽  
Vol 14 (5) ◽  
pp. R181 ◽  
Author(s):  
Paula Dennen ◽  
Christopher Altmann ◽  
Jonathan Kaufman ◽  
Christina L Klein ◽  
Ana Andres-Hernando ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Interleukin 6 ◽  
Kidney Injury ◽  
Early Biomarker

scholarly journals Urinary Klotho measured by ELISA as an early biomarker of acute kidney injury in patients after cardiac surgery or coronary angiography

2015 ◽  
Vol 35 (2) ◽  
pp. 172-178
Author(s):  
Isidro Torregrosa ◽  
Carmina Montoliu ◽  
Amparo Urios ◽  
Carla Giménez-Garzó ◽  
Patricia Tomás ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Coronary Angiography ◽  
Kidney Injury ◽  
Early Biomarker

Neutrophil gelatinase-associated lipocalin reflects inflammation and is not a reliable renal biomarker in neonates and infants after cardiopulmonary bypass: a prospective case–control study

2017 ◽  
Vol 28 (2) ◽  
pp. 243-251 ◽  
Author(s):  
Karl Reiter ◽  
Gunter Balling ◽  
Vittorio Bonelli ◽  
Jelena Pabst von Ohain ◽  
Siegmund Lorenz Braun ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Interleukin 6 ◽  
Inflammatory Diseases ◽  
Kidney Injury ◽  
Cardiopulmonary Bypass Time ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neonates And Infants ◽  
Neutrophil Gelatinase

AbstractIntroductionAcute kidney injury is a frequent complication after cardiac surgery with cardiopulmonary bypass in infants. Neutrophil gelatinase-associated lipocalin has been suggested to be a promising early biomarker of impending acute kidney injury. On the other hand, neutrophil gelatinase-associated lipocalin has been shown to be elevated in systemic inflammatory diseases without renal impairment. In this secondary analysis of data from our previous study on acute kidney injury after infant cardiac surgery, our hypothesis was that neutrophil gelatinase-associated lipocalin may be associated with surgery-related inflammation.MethodsWe prospectively enrolled 59 neonates and infants undergoing cardiopulmonary bypass surgery for CHD and measured neutrophil gelatinase-associated lipocalin in plasma and urine and interleukin-6 in the plasma. Values were correlated with postoperative acute kidney injury according to the paediatric Renal-Injury-Failure-Loss-Endstage classification.ResultsOverall, 48% (28/59) of patients developed acute kidney injury. Of these, 50% (14/28) were classified as injury and 11% (3/28) received renal replacement therapy. Both plasma and urinary neutrophil gelatinase-associated lipocalin values were not correlated with acute kidney injury occurrence. Plasma neutrophil gelatinase-associated lipocalin showed a strong correlation with interleukin-6. Urinary neutrophil gelatinase-associated lipocalin values correlated with cardiopulmonary bypass time.ConclusionOur results suggest that plasma and urinary neutrophil gelatinase-associated lipocalin values are not reliable indicators of impending acute kidney injury in neonates and infants after cardiac surgery with cardiopulmonary bypass. Inflammation may have a major impact on plasma neutrophil gelatinase-associated lipocalin values in infant cardiac surgery. Urinary neutrophil gelatinase-associated lipocalin may add little prognostic value over cardiopulmonary bypass time.

scholarly journals Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery

2015 ◽  
Vol 30 (9) ◽  
pp. 1519-1527 ◽  
Author(s):  
Jason H. Greenberg ◽  
◽  
Richard Whitlock ◽  
William R. Zhang ◽  
Heather R. Thiessen-Philbrook ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Interleukin 6 ◽  
Kidney Injury ◽  
Interleukin 10 ◽  
Pediatric Cardiac Surgery

scholarly journals Urine klotho is a potential early biomarker for acute kidney injury and associated with poor renal outcome after cardiac surgery

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Yingying Qian ◽  
Lin Che ◽  
Yucheng Yan ◽  
Renhua Lu ◽  
Mingli Zhu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Injury ◽  
Renal Outcome ◽  
Early Biomarker

scholarly journals SP229URINARY CADMIUM AS AN EARLY BIOMARKER OF ACUTE KIDNEY INJURY AFTER CARDIAC SURGERY

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i420-i420
Author(s):  
Jennifer Allen ◽  
David Gardner ◽  
Henry Skinner ◽  
David Richens ◽  
Adam Szafranek ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Injury ◽  
Early Biomarker
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