scholarly journals Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study

Critical Care ◽  
2009 ◽  
Vol 13 (4) ◽  
pp. R104 ◽  
Author(s):  
Kathleen D Liu ◽  
Christopher Altmann ◽  
Gerard Smits ◽  
Catherine D Krawczeski ◽  
Charles L Edelstein ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Interleukin 6 ◽  
Case Control Study ◽  
Prolonged Mechanical Ventilation ◽  
Kidney Injury ◽  
Case Control ◽  
Early Biomarkers ◽  
Control Study

scholarly journals Novel Plasma Biomarker-Based Model for Predicting Acute Kidney Injury After Cardiac Surgery: A Case Control Study

2022 ◽  
Vol 8 ◽  
Author(s):  
Yichi Zhang ◽  
Haige Zhao ◽  
Qun Su ◽  
Cuili Wang ◽  
Hongjun Chen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Cost Of Care ◽  
Clinical Factor ◽  
Prediction Ability ◽  
C Statistic ◽  
Control Study

Introduction:Acute kidney injury (AKI) after cardiac surgery is independently associated with a prolonged hospital stay, increased cost of care, and increased post-operative mortality. Delayed elevation of serum creatinine (SCr) levels requires novel biomarkers to provide a prediction of AKI after cardiac surgery. Our objective was to find a novel blood biomarkers combination to construct a model for predicting AKI after cardiac surgery and risk stratification.Methods:This was a case-control study. Weighted Gene Co-expression Network Analysis (WGCNA) was applied to Gene Expression Omnibus (GEO) dataset GSE30718 to seek potential biomarkers associated with AKI. We measured biomarker levels in venous blood samples of 67 patients with AKI after cardiac surgery and 59 control patients in two cohorts. Clinical data were collected. We developed a multi-biomarker model for predicting cardiac-surgery-associated AKI and compared it with a traditional clinical-factor-based model.Results:From bioinformatics analysis and previous articles, we found 6 potential plasma biomarkers for the prediction of AKI. Among them, 3 biomarkers, such as growth differentiation factor 15 (GDF15), soluble suppression of tumorigenicity 2 (ST2, IL1RL1), and soluble urokinase plasminogen activator receptor (uPAR) were found to have prediction ability for AKI (area under the curve [AUC] > 0.6) in patients undergoing cardiac surgery. They were then incorporated into a multi-biomarker model for predicting AKI (C-statistic: 0.84, Brier 0.15) which outperformed the traditional clinical-factor-based model (C-statistic: 0.73, Brier 0.16).Conclusion:Our research validated a promising plasma multi-biomarker model for predicting AKI after cardiac surgery.

MP217DIABETES MELLITUS DOES NOT INCREASE THE INCIDENCE OF ACUTE KIDNEY INJURY AFTER CARDIAC SURGERY IN PATIENTS WITH CHRONIC KIDNEY DISEASE; A NESTED CASE-CONTROL STUDY

2016 ◽  
Vol 31 (suppl_1) ◽  
pp. i412-i412
Author(s):  
Loutradis Charalampos ◽  
Maria Moschopoulou ◽  
Foteini Ampatzidou ◽  
Afroditi Mpoutou ◽  
Charilaos-Panagiotis Koutsogiannidis ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Disease ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

Diabetes mellitus does not affect the incidence of acute kidney injury after cardiac surgery; a nested case–control study

2016 ◽  
Vol 29 (6) ◽  
pp. 835-845
Author(s):  
Maria Moschopoulou ◽  
Foteini Ch. Ampatzidou ◽  
Charalampos Loutradis ◽  
Afroditi Boutou ◽  
Charilaos-Panagiotis Koutsogiannidis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case–control study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041543
Author(s):  
Keiko Ikuta ◽  
Shunsaku Nakagawa ◽  
Kenji Momo ◽  
Atsushi Yonezawa ◽  
Kotaro Itohara ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Case Control Study ◽  
Kidney Injury ◽  
Case Control ◽  
Renal Diseases ◽  
Increased Risk ◽  
Nested Case Control ◽  
Control Study

ObjectivesThis study aimed to assess whether the combined use of proton pump inhibitors (PPIs) with non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics (penicillins, macrolides, cephalosporins or fluoroquinolones) was associated with an increased risk of acute kidney injury (AKI).DesignA nested case–control study.SettingA health insurance claims database constructed by the Japan Medical Data Center.ParticipantsPatients were eligible if they were prescribed a PPI, NSAID and antibiotic at least once between January 2005 and June 2017. The patients who were new PPI users and did not have any history of renal diseases before cohort entry were included (n=219 082). The mean age was 45 and 44% were women.InterventionsCurrent use of PPIs, NSAIDs, or antibiotics.Primary outcome measuresAcute kidney injury.ResultsDuring a mean follow-up of 2.4 (SD, 1.7) years, 317 cases of AKI were identified (incidence rate of 6.1/10 000 person-years). The current use of PPIs was associated with a higher risk of AKI compared with past PPI use (unadjusted OR, 4.09; 95% CI, 3.09 to 5.44). The unadjusted ORs of AKI for the current use of PPIs with NSAIDs, cephalosporins and fluoroquinolones, compared with the current use of PPIs alone, were 3.92 (95% CI, 2.40 to 6.52), 2.57 (1.43 to 4.62) and 3.08 (1.50 to 6.38), respectively. The effects of concurrent use of PPIs with NSAIDs, cephalosporins or fluoroquinolones remain significant in the adjusted model. The analyses on absolute risk of AKI confirmed the results from the nested case–control study.ConclusionsConcomitant use of NSAIDs with PPIs significantly increased the risk for AKI. Moreover, the results suggested that concomitant use of cephalosporins or fluoroquinolones with PPIs was associated with increased risk of incident AKI.

scholarly journals Correction to: Is metformin associated with acute kidney injury? A case–control study of patients with type 2 diabetes admitted with acute infection

2020 ◽  
Author(s):  
Philip Andreas Schytz ◽  
Anders Bonde Nissen ◽  
Kristine Hommel ◽  
Morten Schou ◽  
Karl Emil Nelveg-Kristensen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Acute Kidney Injury ◽  
Case Control Study ◽  
Acute Infection ◽  
Kidney Injury ◽  
Case Control ◽  
Control Study
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