scholarly journals Efficacy and safety of once daily dosing of colistin to critically ill patients

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P56
Author(s):  
A Skiada ◽  
J Pavleas ◽  
T Topalis ◽  
K Georgiou ◽  
D Siggouna ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Efficacy And Safety ◽  
Once Daily

Efficacy and Safety of Once-Daily Amikacin in Combination with Ceftazidime in Critically Ill Adults with Severe Gram-Negative Infections

1996 ◽  
Vol 8 (6) ◽  
pp. 457-464 ◽  
Author(s):  
D.F. Fayed ◽  
N.S. Dahmash ◽  
A.H. Al-Zeer ◽  
A.M. Shibl ◽  
S.O. Huraib ◽  
...  
Keyword(s):  
Critically Ill ◽  
Efficacy And Safety ◽  
Once Daily ◽  
Gram Negative ◽  
Critically Ill Adults ◽  
Ill Adults

scholarly journals Fluid Removal With Ultrasound Guided Protocol Improves the Efficacy and Safety of Dehydration in Post-Resuscitated Critically Ill Patients

Shock ◽  
2018 ◽  
Vol 50 (4) ◽  
pp. 401-407 ◽  
Author(s):  
Luhao Wang ◽  
Chunfang Qiu ◽  
Xiangdong Guan ◽  
Minying Chen ◽  
Juan Chen ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Efficacy And Safety ◽  
Ultrasound Guided ◽  
Fluid Removal

Dalteparin Thromboprophylaxis in Critically Ill Patients with Severe Renal Insufficiency: The Direct Study.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 304-304
Author(s):  
James Douketis ◽  
Deborah Cook ◽  
Nicole Zytaruks ◽  
Diane Heels-Ansdell ◽  
Mark Crowther
Keyword(s):  
Renal Insufficiency ◽  
Creatinine Clearance ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Bleeding Risk ◽  
Open Label ◽  
Once Daily ◽  
Major Bleed ◽  
Severe Renal Insufficiency ◽  
Pharmacodynamic Profile

Abstract Background: Critically ill patients with renal insufficiency are at high risk for deep vein thrombosis (DVT). Low-molecular-weight heparins (LMWHs) effectively prevent DVT but are avoided in patients with renal insufficiency because of potential bioaccumulation and potential bleeding risk. However, evidence is lacking that LMWHs bioaccumulate in such patients. Objectives: The objectives of DIRECT were, in critically ill patients with severe renal insufficiency, to determine if dalteparin prophylaxis leads to bioaccumulation and bleeding from excessive anticoagulation and to determine the pharmacodynamic profile of dalteparin. Methods: Multi-center, open-label, prospective cohort study of critically ill patients with a creatinine clearance <30 mL/min who receive dalteparin, 5000 IU once-daily, subcutaneously for up to 30 days. Dalteparin bioaccumulation in a patient was defined by a trough anti-Xa level >0.40 IU/mL, measured twice-weekly 20 hours after the prior dalteparin dose. The pharmacodynamic profile of dalteparin was assessed by anti-Xa levels measured at 0, 1, 2, 4, 8, 12, 20, and 24 hours after the prior dose on days 3, 10, and 17 of treatment. Results: We enrolled 156 patients with a mean (SD) creatinine clearance of 18.9 (6.5) mL/min; of these, 18 were excluded because they died or were discharged before testing (n = 3) or had prevalent DVT (n = 14) or pulmonary embolism (n = 1) within 48 hours of enrollment. Of 138 patients included, the median (inter-quartile range [IQR]) duration of dalteparin treatment was 7 days (4, 12). In 120 pa tients who had ≥1 trough anti-Xa measured (427 total), none had dalteparin bioaccumulation; the median (IQR) trough anti-Xa level was <0.1 IU/mL (<0.1, <0.1). In 138 patients who received ≥1 dose of dalteparin,10 patients (7.2%; 95% CI: 4.0, 12.8) had a major bleed, all with trough anti-Xa levels ≤0.18 IU/mL. The pharmacodynamic profile of dalteparin, shown in the Figure, was typical for drugs that do not bioaccumulate, with a typical peak and decline after 3, 10, and 17 days of treatment. Conclusions: In critically ill patients with severe renal insufficiency, thromboprophylaxis with dalteparin did not bioaccumulate. Dalteparin, 5000 IU once-daily, appears to be a reasonable option for thromboprophylaxis of critically ill patients with severe renal insufficiency. Figure Figure

Efficacy and Safety of Percutaneous Dilatation Tracheostomy (PDT) in Critically Ill Patients When Performed Bedside by an Intensivist With Flexible Bronchoscopy Assistance

CHEST Journal ◽  
2011 ◽  
Vol 140 (4) ◽  
pp. 193A
Author(s):  
Kyriaki Tsikritsaki ◽  
Georgios Koukoulitsios ◽  
Agisilaos Dervas ◽  
Maria Kryfti ◽  
Ioannis Dimitroulis
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Flexible Bronchoscopy ◽  
Efficacy And Safety ◽  
Percutaneous Dilatation

ONCE-DAILY AMINOGLYCOSIDE DOSING FOR CRITICALLY ILL PATIENTS WITH RENAL INSUFFICIENCY

1999 ◽  
Vol 27 (Supplement) ◽  
pp. A124 ◽  
Author(s):  
Candace J Smith ◽  
Corrado P Marini ◽  
Garry S Ritter
Keyword(s):  
Renal Insufficiency ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Once Daily

scholarly journals Parenteral polymyxins: Assessing efficacy and safety in critically ill patients with renal dysfunction

2013 ◽  
Vol 45 (6) ◽  
pp. 608 ◽  
Author(s):  
Kavita Sekhri ◽  
Ruchika Nandha ◽  
Amit Mandal ◽  
Deepak Bhasin ◽  
Harpal Singh
Keyword(s):  
Renal Dysfunction ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Efficacy And Safety
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