scholarly journals Effect of cardiopulmonary bypass on activated partial thromboplastin time waveform analysis, serum procalcitonin and C-reactive protein concentrations

Critical Care ◽  
2009 ◽  
Vol 13 (6) ◽  
pp. R180 ◽  
Author(s):  
Bertrand Delannoy ◽  
Marie-Laurence Guye ◽  
Davy Slaiman ◽  
Jean-Jacques Lehot ◽  
Maxime Cannesson
Keyword(s):  
Cardiopulmonary Bypass ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
Waveform Analysis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Time Waveform

Activated partial thromboplastin time waveform analysis: A new tool to detect infection?*

2006 ◽  
Vol 34 (6) ◽  
pp. 1654-1660 ◽  
Author(s):  
Nicolas Chopin ◽  
Bernard Floccard ◽  
Frédéric Sobas ◽  
Julien Illinger ◽  
Emmanuel Boselli ◽  
...  
Keyword(s):  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
Waveform Analysis ◽  
Time Waveform

False prolongation of the activated partial thromboplastin time (aPTT) in inflammatory patients: interference of C-reactive protein

2012 ◽  
Vol 157 (3) ◽  
pp. 394-395 ◽  
Author(s):  
André P. van Rossum ◽  
L. Tom Vlasveld ◽  
Laura J. M. van den Hoven ◽  
Carla W. M. de Wit ◽  
Ad Castel
Keyword(s):  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Anti-phospholipid antibodies in COVID-19 are different from those detectable in the anti-phospholipid syndrome

2020 ◽  
Author(s):  
Maria Orietta Borghi ◽  
Asmaa Beltagy ◽  
Emirena Garrafa ◽  
Daniele Curreli ◽  
Germana Cecchini ◽  
...  
Keyword(s):  
Critically Ill Patients ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Functional Assays ◽  
Epitope Specificity ◽  
Glycoprotein I ◽  
Low Prevalence ◽  
Anti Phospholipid Syndrome

AbstractBackgroundCritically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure and death. Because of a prolonged activated partial-thromboplastin time (aPTT), a relationship with anti-phospholipid antibodies (aPL) has been proposed, but results are controversial. Functional assays for aPL (i.e., lupus anticoagulant) can be influenced by concomitant anticoagulation and/or high levels of C reactive protein. The presence of anti-cardiolipin (aCL), anti-beta2-glycoprotein I (anti-β2GPI) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies was not investigated systematically. Epitope specificity of anti-β2GPI antibodies was not reported.ObjectiveTo evaluate the prevalence and the clinical association of aPL in a large cohort of COVID-19 patients, and to characterize the epitope specificity of anti-β2GPI antibodies.MethodsELISA and chemiluminescence assays were used to test 122 sera of patients suffering from severe COVID-19. Of them, 16 displayed major thrombotic events.ResultsAnti-β2GPI IgG/IgA/IgM were the most frequent in 15.6/6.6/9.0% of patients, while aCL IgG/IgM were detected in 5.7/6.6% by ELISA. Comparable values were found by chemiluminescence. aPS/PT IgG/IgM were detectable in 2.5 and 9.8% by ELISA. No association between thrombosis and aPL was found. Reactivity against domain 1 and 4-5 of β2GPI was limited to 3/58 (5.2%) tested sera for each domain and did not correlate with aCL/anti-β2GPI nor with thrombosis.ConclusionsaPL show a low prevalence in COVID-19 patients and are not associated with major thrombotic events. aPL in COVID-19 patients are mainly directed against β2GPI but display an epitope specificity different from antibodies in antiphospholipid syndrome.

scholarly journals Inter-individual variability in phospholipid-dependent interference of C-reactive protein on activated partial thromboplastin time

2017 ◽  
Vol 183 (4) ◽  
pp. 681-683
Author(s):  
Lale Erdem-Eraslan ◽  
Jacques J. H. Hens ◽  
André P. van Rossum ◽  
Marieke A. M. Frasa ◽  
Jeffrey F. W. Keuren
Keyword(s):  
Partial Thromboplastin Time ◽  
Individual Variability ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein
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