scholarly journals Inter-individual variability in phospholipid-dependent interference of C-reactive protein on activated partial thromboplastin time

2017 ◽  
Vol 183 (4) ◽  
pp. 681-683
Author(s):  
Lale Erdem-Eraslan ◽  
Jacques J. H. Hens ◽  
André P. van Rossum ◽  
Marieke A. M. Frasa ◽  
Jeffrey F. W. Keuren
Keyword(s):  
Partial Thromboplastin Time ◽  
Individual Variability ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein

False prolongation of the activated partial thromboplastin time (aPTT) in inflammatory patients: interference of C-reactive protein

2012 ◽  
Vol 157 (3) ◽  
pp. 394-395 ◽  
Author(s):  
André P. van Rossum ◽  
L. Tom Vlasveld ◽  
Laura J. M. van den Hoven ◽  
Carla W. M. de Wit ◽  
Ad Castel
Keyword(s):  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Anti-phospholipid antibodies in COVID-19 are different from those detectable in the anti-phospholipid syndrome

2020 ◽  
Author(s):  
Maria Orietta Borghi ◽  
Asmaa Beltagy ◽  
Emirena Garrafa ◽  
Daniele Curreli ◽  
Germana Cecchini ◽  
...  
Keyword(s):  
Critically Ill Patients ◽  
Partial Thromboplastin Time ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Functional Assays ◽  
Epitope Specificity ◽  
Glycoprotein I ◽  
Low Prevalence ◽  
Anti Phospholipid Syndrome

AbstractBackgroundCritically ill patients with coronavirus disease 2019 (COVID-19) have a profound hypercoagulable state and often develop coagulopathy which leads to organ failure and death. Because of a prolonged activated partial-thromboplastin time (aPTT), a relationship with anti-phospholipid antibodies (aPL) has been proposed, but results are controversial. Functional assays for aPL (i.e., lupus anticoagulant) can be influenced by concomitant anticoagulation and/or high levels of C reactive protein. The presence of anti-cardiolipin (aCL), anti-beta2-glycoprotein I (anti-β2GPI) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies was not investigated systematically. Epitope specificity of anti-β2GPI antibodies was not reported.ObjectiveTo evaluate the prevalence and the clinical association of aPL in a large cohort of COVID-19 patients, and to characterize the epitope specificity of anti-β2GPI antibodies.MethodsELISA and chemiluminescence assays were used to test 122 sera of patients suffering from severe COVID-19. Of them, 16 displayed major thrombotic events.ResultsAnti-β2GPI IgG/IgA/IgM were the most frequent in 15.6/6.6/9.0% of patients, while aCL IgG/IgM were detected in 5.7/6.6% by ELISA. Comparable values were found by chemiluminescence. aPS/PT IgG/IgM were detectable in 2.5 and 9.8% by ELISA. No association between thrombosis and aPL was found. Reactivity against domain 1 and 4-5 of β2GPI was limited to 3/58 (5.2%) tested sera for each domain and did not correlate with aCL/anti-β2GPI nor with thrombosis.ConclusionsaPL show a low prevalence in COVID-19 patients and are not associated with major thrombotic events. aPL in COVID-19 patients are mainly directed against β2GPI but display an epitope specificity different from antibodies in antiphospholipid syndrome.

scholarly journals Comparison of Clinical Features on Admission Between Coronavirus Disease 2019 and Influenza A among Children: A Retrospective Study in China

2020 ◽  
Author(s):  
Feng Liang ◽  
Xianfeng Wang ◽  
Hui Li ◽  
Jun Chen ◽  
Lei Liu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Neutrophil Count ◽  
Influenza A ◽  
Clinical Characteristics ◽  
Nasal Congestion ◽  
Severe Infection ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Time Of Admission

Abstract Background: Coronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission. Methods: A total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared. Results: Fever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. The IA patients were more likely to have lower-than-normal levels of lymphocyte count and percentage and to have higher-than-normal levels of activated partial thromboplastin time, prothrombin time, serum C-reactive protein, and serum procalcitonin, while the COVID-19 patients had higher odds of having lower-than-normal levels of neutrophil count and percentage.Conclusions: This study suggests that influenza A is more symptomatic than COVID-19 for children and might be an overall more severe infection at the time of admission.

scholarly journals Intra-Individual Variability of High-Sensitivity C-Reactive Protein

2006 ◽  
Vol 70 (5) ◽  
pp. 559-563 ◽  
Author(s):  
Ali Nasermoaddeli ◽  
Michikazu Sekine ◽  
Sadanobu Kagamimori
Keyword(s):  
High Sensitivity ◽  
Individual Variability ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Comparison of clinical features on admission between coronavirus disease 2019 and influenza a among children: a retrospective study in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Feng Liang ◽  
Xianfeng Wang ◽  
Jianbo Shao ◽  
Jun Chen ◽  
Lei Liu ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Neutrophil Count ◽  
Influenza A ◽  
Clinical Characteristics ◽  
Nasal Congestion ◽  
Severe Infection ◽  
Activated Partial Thromboplastin Time ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Time Of Admission

Abstract Background Coronavirus disease 2019 (COVID-19) share similar symptoms with influenza A (IA), but it is more worthwhile to understand the disparities of the two infections regarding their clinical characteristics on admission. Methods A total of 71 age-matched pediatric IA and COVID-19 patient pairs were formed and their clinical data on admission were compared. Results Fever, cough, nasal congestion and nausea/vomiting were the most common symptoms on admission for both infections but occurred less often in COVID-19. The IA patients were more likely to have lower-than-normal levels of lymphocyte count and percentage and to have higher-than-normal levels of activated partial thromboplastin time, prothrombin time, serum C-reactive protein, and serum procalcitonin, while the COVID-19 patients had higher odds of having lower-than-normal levels of neutrophil count and percentage. Conclusions This study suggests that influenza A is more symptomatic than COVID-19 for children and might be an overall more severe infection at the time of admission.

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