scholarly journals Matrix metalloproteinase-1, soluble Fas ligand, and soluble Fas antigen levels in patients with multiple organ dysfunction syndrome

Critical Care ◽  
10.1186/cc161 ◽  
1998 ◽  
Vol 2 (Suppl 1) ◽  
pp. P031
Author(s):  
S Endo ◽  
T Kasai ◽  
T Takakuwa ◽  
H Nakae ◽  
Y Yamada ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Organ Dysfunction ◽  
Fas Ligand ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Fas Antigen ◽  
Soluble Fas ◽  
Matrix Metalloproteinase 1 ◽  
Soluble Fas Antigen ◽  
Soluble Fas Ligand

Serum concentrations of soluble Fas antigen and soluble Fas ligand in mother and newborn

2000 ◽  
Vol 263 (3) ◽  
pp. 108-110 ◽  
Author(s):  
H. Iwama ◽  
H. Akutsu ◽  
S. Kuretake ◽  
J. Tohma ◽  
N. Nakamura
Keyword(s):  
Fas Ligand ◽  
Serum Concentrations ◽  
Fas Antigen ◽  
Soluble Fas ◽  
Soluble Fas Antigen ◽  
Soluble Fas Ligand

Soluble Fas Antigen and Soluble Fas Ligand in Intrauterine Growth Restriction

Neonatology ◽  
2010 ◽  
Vol 97 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Despina D. Briana ◽  
Stavroula Baka ◽  
Maria Boutsikou ◽  
Sofia Liosi ◽  
Venetia-Maria Vraila ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Fas Ligand ◽  
Growth Restriction ◽  
Fas Antigen ◽  
Intrauterine Growth ◽  
Soluble Fas ◽  
Soluble Fas Antigen ◽  
Soluble Fas Ligand

Soluble Fas antigen and soluble Fas ligand in early neonatal life

2003 ◽  
Vol 75 (1-2) ◽  
pp. 1-7 ◽  
Author(s):  
Angeliki Sarandakou ◽  
Efthimia Protonotariou ◽  
Dimitrios Rizos ◽  
Lygeri Soubassi ◽  
Ariadni Malamitsi-Puchner
Keyword(s):  
Fas Ligand ◽  
Fas Antigen ◽  
Soluble Fas ◽  
Neonatal Life ◽  
Soluble Fas Antigen ◽  
Soluble Fas Ligand

SOLUBLE FAS LEVELS CORRELATE WITH MULTIPLE ORGAN DYSFUNCTION SEVERITY, SURVIVAL AND NITRATE LEVELS, BUT NOT WITH CELLULAR APOPTOTIC MARKERS IN CRITICALLY ILL PATIENTS

Shock ◽  
2000 ◽  
Vol 14 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Elizabeth D. E. Papathanassoglou ◽  
Jan A. Moynihan ◽  
Dianne L. Vermillion ◽  
Michael P. McDermott ◽  
Michael H. Ackerman
Keyword(s):  
Critically Ill ◽  
Organ Dysfunction ◽  
Critically Ill Patients ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Soluble Fas ◽  
Apoptotic Markers

Association of Proinflammatory Molecules with Apoptotic Markers and Survival in Critically Ill Multiple Organ Dysfunction Patients

2003 ◽  
Vol 5 (2) ◽  
pp. 129-141 ◽  
Author(s):  
Elizabeth D. E. Papathanassoglou ◽  
Jan A. Moynihan ◽  
Ourania Dafni ◽  
Christos S. Mantzoros ◽  
Michael H. Ackerman
Keyword(s):  
Critically Ill ◽  
Organ Dysfunction ◽  
Fas Ligand ◽  
Mononuclear Cells ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Peripheral Blood Mononuclear ◽  
Tnf Α ◽  
Inflammatory Molecules ◽  
Necrosis Factor

Recent evidence supports the involvement of apoptosis in multiple organ dysfunction (MODS). The authors examined the hypothesis that nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α , and cortisol correlate with Fas and Fas ligand (FasL) expression on peripheral blood mononuclear cells and that Fas and FasL, therefore, mediate their association with MODS severity. Thirty-five critically ill adult MODS patients were followed for up to 14 days and were compared to non-MODS matched controls. Fas, FasL, nitrate, cortisol, and IL-6 were elevated in MODS patients (P < 0.05). Nitrate and cortisol correlated with Fas expression (P < 0.05). All factors studied, except for TNF-α , correlated with MODS severity (P < 0.05); however, by multivariate analyses, Fas and FasL were independently associated with severity and survival (P < 0.05). The inflammatory molecules studied may mediate the association of apoptotic constituents with MODS severity and survival only in part.

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

Multiple Organ Dysfunction Syndrome of Alcoholic Origin in an 18-Year-Old Patient

2018 ◽  
Vol 2 (12) ◽  
Author(s):  
Francesco Gazia ◽  
Giacomo De Luca ◽  
Imbalzano Gabriele ◽  
Vincenzo Pellicanò
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction

IMPACT probability of poor outcome and plasma cytokine concentrations are associated with multiple organ dysfunction syndrome following traumatic brain injury

2019 ◽  
Vol 131 (6) ◽  
pp. 1931-1937 ◽  
Author(s):  
Sungho Lee ◽  
Hyunsoo Hwang ◽  
Jose-Miguel Yamal ◽  
J. Clay Goodman ◽  
Imoigele P. Aisiku ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Sofa Score ◽  
Plasma Concentrations ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Poor Outcome ◽  
Initial Plasma

OBJECTIVETraumatic brain injury (TBI) is a major cause of morbidity and mortality. Multiple organ dysfunction syndrome (MODS) occurs frequently after TBI and independently worsens outcome. The present study aimed to identify potential admission characteristics associated with post-TBI MODS.METHODSThe authors performed a secondary analysis of a recent randomized clinical trial studying the effects of erythropoietin and blood transfusion threshold on neurological recovery after TBI. Admission clinical, demographic, laboratory, and imaging parameters were used in a multivariable Cox regression analysis to identify independent risk factors for MODS following TBI, defined as maximum total Sequential Organ Failure Assessment (SOFA) score > 7 within 10 days of TBI.RESULTSTwo hundred patients were initially recruited and 166 were included in the final analysis. Respiratory dysfunction was the most common nonneurological organ system dysfunction, occurring in 62% of the patients. International Mission for Prognosis and Analysis of Clinical Trials (IMPACT) probability of poor outcome at admission was significantly associated with MODS following TBI (odds ratio [OR] 8.88, 95% confidence interval [CI] 1.94–42.68, p < 0.05). However, more commonly used measures of TBI severity, such as the Glasgow Coma Scale, Injury Severity Scale, and Marshall classification, were not associated with post-TBI MODS. In addition, initial plasma concentrations of interleukin (IL)–6, IL-8, and IL-10 were significantly associated with the development of MODS (OR 1.47, 95% CI 1.20–1.80, p < 0.001 for IL-6; OR 1.26, 95% CI 1.01–1.58, p = 0.042 for IL-8; OR 1.77, 95% CI 1.24–2.53, p = 0.002 for IL-10) as well as individual organ dysfunction (SOFA component score ≥ 1). Finally, MODS following TBI was significantly associated with mortality (OR 5.95, 95% CI 2.18–19.14, p = 0.001), and SOFA score was significantly associated with poor outcome at 6 months (Glasgow Outcome Scale score < 4) when analyzed as a continuous variable (OR 1.21, 95% CI 1.06–1.40, p = 0.006).CONCLUSIONSAdmission IMPACT probability of poor outcome and initial plasma concentrations of IL-6, IL-8, and IL-10 were associated with MODS following TBI.

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