scholarly journals Prospective immune profiling in critically ill adults: before, during and after severe sepsis and septic shock

Critical Care ◽  
2015 ◽  
Vol 19 (Suppl 1) ◽  
pp. P43 ◽  
Author(s):  
N Layios
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Adults ◽  
Sepsis And Septic Shock ◽  
Ill Adults ◽  
Immune Profiling

Bloodstream Infection-Associated Sepsis and Septic Shock in Critically Ill Adults: A Population-Based Study

Infection ◽  
2004 ◽  
Vol 32 (2) ◽  
pp. 59-64 ◽  
Author(s):  
K. B. Laupland ◽  
H. D. Davies ◽  
D. L. Church ◽  
T. J. Louie ◽  
J. S. Dool ◽  
...  
Keyword(s):  
Septic Shock ◽  
Bloodstream Infection ◽  
Critically Ill ◽  
Population Based ◽  
Population Based Study ◽  
Critically Ill Adults ◽  
Sepsis And Septic Shock ◽  
Ill Adults

The emergency patient

2021 ◽  
pp. 1033-1050
Author(s):  
Shardha Chandrasekharan ◽  
Ravi Mistry ◽  
Daniel Frei
Keyword(s):  
Septic Shock ◽  
Tracheal Intubation ◽  
Critically Ill ◽  
Emergency Laparotomy ◽  
Emergency Patient ◽  
Critically Ill Adults ◽  
Sepsis And Septic Shock ◽  
Ill Adults

This chapter discusses the management of the emergency patient. It begins with tracheal intubation of critically ill adults then discusses sepsis and septic shock, the emergency laparotomy, the ICU patient going to theatre and transferring the critically ill.

scholarly journals Chronically critically ill patients: different behavior in severe sepsis and septic shock?

2015 ◽  
Vol 3 (S1) ◽  
Author(s):  
DH Prevedello ◽  
A Rea-Neto ◽  
HA Teive ◽  
LA Tannous ◽  
RAO Deucher ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Chronically Critically Ill ◽  
Sepsis And Septic Shock

scholarly journals Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem during the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units

2015 ◽  
Vol 59 (6) ◽  
pp. 2995-3001 ◽  
Author(s):  
Sutep Jaruratanasirikul ◽  
Suriyan Thengyai ◽  
Wibul Wongpoowarak ◽  
Thitima Wattanavijitkul ◽  
Kanyawisa Tangkitwanitjaroen ◽  
...  
Keyword(s):  
Septic Shock ◽  
Monte Carlo ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Early Phase ◽  
Volume Of Distribution ◽  
Therapeutic Success ◽  
Altered Pharmacokinetic ◽  
Sepsis And Septic Shock

ABSTRACTPathophysiological changes during the early phase of severe sepsis and septic shock in critically ill patients, resulting in altered pharmacokinetic (PK) patterns for antibiotics, are important factors influencing therapeutic success. The aims of this study were (i) to reveal the population PK parameters and (ii) to assess the probability of target attainment (PTA) for meropenem. The PK studies were carried out following administration of 1 g of meropenem every 8 h during the first 24 h of severe sepsis and septic shock in nine patients, and a Monte Carlo simulation was performed to determine the PTA of achieving 40% exposure time during which the free plasma drug concentration remains above the MIC (fT>MIC) and 80%fT>MIC. The volume of distribution (V) and total clearance (CL) of meropenem in these patients were 23.7 liters and 7.82 liters/h, respectively. For pathogens with MICs of 4 μg/ml, the PTAs of 40%fT>MICfollowing administration of meropenem as a 1-h infusion of 1 g every 8 h and a 4-h infusion of 0.5 g every 8 h were 92.52% and 90.29%, respectively. For pathogens with MICs of 2 μg/ml in immunocompromised hosts, the PTAs of 80%fT>MICfollowing administration of 1-h and 4-h infusions of 2 g of meropenem every 8 h were 84.32% and 94.72%, respectively. These findings indicated that theVof meropenem was greater and the CL of meropenem was lower than the values obtained in a previous study with healthy subjects. The maximum recommended dose, i.e., 2 g of meropenem every 8 h, may be required for treatment of life-threatening infections in this patient population.

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