Antimicrobial Pharmacokinetic and Pharmacodynamic Issues in the Critically Ill with Severe Sepsis and Septic Shock

2011 ◽  
Vol 27 (1) ◽  
pp. 19-34 ◽  
Author(s):  
Julie M. Varghese ◽  
Jason A. Roberts ◽  
Jeffrey Lipman
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Sepsis And Septic Shock

scholarly journals Chronically critically ill patients: different behavior in severe sepsis and septic shock?

2015 ◽  
Vol 3 (S1) ◽  
Author(s):  
DH Prevedello ◽  
A Rea-Neto ◽  
HA Teive ◽  
LA Tannous ◽  
RAO Deucher ◽  
...  
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Chronically Critically Ill ◽  
Sepsis And Septic Shock

scholarly journals Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem during the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units

2015 ◽  
Vol 59 (6) ◽  
pp. 2995-3001 ◽  
Author(s):  
Sutep Jaruratanasirikul ◽  
Suriyan Thengyai ◽  
Wibul Wongpoowarak ◽  
Thitima Wattanavijitkul ◽  
Kanyawisa Tangkitwanitjaroen ◽  
...  
Keyword(s):  
Septic Shock ◽  
Monte Carlo ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Early Phase ◽  
Volume Of Distribution ◽  
Therapeutic Success ◽  
Altered Pharmacokinetic ◽  
Sepsis And Septic Shock

ABSTRACTPathophysiological changes during the early phase of severe sepsis and septic shock in critically ill patients, resulting in altered pharmacokinetic (PK) patterns for antibiotics, are important factors influencing therapeutic success. The aims of this study were (i) to reveal the population PK parameters and (ii) to assess the probability of target attainment (PTA) for meropenem. The PK studies were carried out following administration of 1 g of meropenem every 8 h during the first 24 h of severe sepsis and septic shock in nine patients, and a Monte Carlo simulation was performed to determine the PTA of achieving 40% exposure time during which the free plasma drug concentration remains above the MIC (fT>MIC) and 80%fT>MIC. The volume of distribution (V) and total clearance (CL) of meropenem in these patients were 23.7 liters and 7.82 liters/h, respectively. For pathogens with MICs of 4 μg/ml, the PTAs of 40%fT>MICfollowing administration of meropenem as a 1-h infusion of 1 g every 8 h and a 4-h infusion of 0.5 g every 8 h were 92.52% and 90.29%, respectively. For pathogens with MICs of 2 μg/ml in immunocompromised hosts, the PTAs of 80%fT>MICfollowing administration of 1-h and 4-h infusions of 2 g of meropenem every 8 h were 84.32% and 94.72%, respectively. These findings indicated that theVof meropenem was greater and the CL of meropenem was lower than the values obtained in a previous study with healthy subjects. The maximum recommended dose, i.e., 2 g of meropenem every 8 h, may be required for treatment of life-threatening infections in this patient population.

scholarly journals Dynamics of brain natriuretic peptide in critically ill patients with severe sepsis and septic shock

2013 ◽  
Vol 7 (3) ◽  
pp. 270 ◽  
Author(s):  
AmrS Omar ◽  
Masood ur Rahman ◽  
GurdeepS Dhatt ◽  
GubrilO Salami ◽  
Said Abuhasna
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Brain Natriuretic Peptide ◽  
Critically Ill ◽  
Natriuretic Peptide ◽  
Critically Ill Patients ◽  
Sepsis And Septic Shock

scholarly journals Alkalosis in Critically Ill Patients with Severe Sepsis and Septic Shock

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0168563 ◽  
Author(s):  
Simon Kreü ◽  
Allan Jazrawi ◽  
Jan Miller ◽  
Amir Baigi ◽  
Michelle Chew
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Sepsis And Septic Shock

Treatment of severe sepsis and septic shock in critically ill patients

Heart & Lung ◽  
2012 ◽  
Vol 41 (4) ◽  
pp. 408-409
Author(s):  
Silvio A. Ñamendys-Silva ◽  
Marisol Hernández-Garay
Keyword(s):  
Septic Shock ◽  
Severe Sepsis ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Sepsis And Septic Shock
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