scholarly journals Serum cystatin C predicts vancomycin trough levels better than serum creatinine in hospitalized patients: a cohort study

Critical Care ◽  
2014 ◽  
Vol 18 (3) ◽  
pp. R110 ◽  
Author(s):  
Erin N Frazee ◽  
Andrew D Rule ◽  
Sandra M Herrmann ◽  
Kianoush B Kashani ◽  
Nelson Leung ◽  
...  
Keyword(s):  
Cohort Study ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Hospitalized Patients ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Vancomycin Trough ◽  
Trough Levels ◽  
Better Than

Serum Serum Cystatin C vs Creatinine (SCr) as early marker of acute renal dysfunction- A comparative study

2021 ◽  
Vol 15 (7) ◽  
pp. 2072-2074
Author(s):  
Arafat Ahmad ◽  
Usama Bin Ghaffar ◽  
Sanket Dadarao Hiware ◽  
Mohammed Taher Ali ◽  
Samina Wasi
Keyword(s):  
Serum Creatinine ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Observation Study ◽  
Serum Cystatin ◽  
Early Marker ◽  
Group 2 ◽  
Kidney Functions ◽  
Better Than ◽  
Group 1

Aim: To compare serum creatinine (SCr) and serum cystatin C as early marker of acute kidney dysfunction. Methodology: The present cross sectional observation study consisted of eighty- four ICU admitted patients (critical ill). A randomization of patients into 2 groups was done. Patients with normal kidney functions were put in group 1 while those with impaired kidney functions were in group 2. The estimation of serum creatinine (SCr) and serum cystatin C was done. Mann Whitney U and ch- square test was used for statistical inference. Results: In group 1 patients, mean serum creatinine (SCr) was 0.30± 0.21 mg/dl and in group 2 was 0.56±0.41 mg/dl. Serum cystatin C level in group 1patients found to be 0.42±0.17 mg/l and 1.5±0.68 mg/l in group 2 patients. Accuracy for Cys- C was better than SCr (90% vs 67%). Specificity for SCr was 97% whereas for Cys- C was 95%. Sensitivity for Cys-C was 80% while for SCr was 25%. SCr had PPV of 92% and NPV of 61% and for Cys- C it was 93% and 83% respectively. Conclusion: Serum cystatin C found to be better than serum creatinine for the identification of impairment of kidney functions in critically ill patients. Hence, assessment of Cys-C is of great concern in AKI. Key words: Acute renal failure, serum creatinine, serum, renal impairment

scholarly journals Reference intervals for serum cystatin C and serum creatinine in an adult sub-Saharan African population

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Bertille Elodie Edinga-Melenge ◽  
Adrienne Tchapmi Yakam ◽  
Jobert Richie Nansseu ◽  
Catherine Bilong ◽  
Suzanne Belinga ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Cystatin C ◽  
Reference Intervals ◽  
African Population ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Sub Saharan

scholarly journals Comparison of estimated GFR equations based on serum cystatin C alone and in combination with serum creatinine in patients with coronary artery disease

2015 ◽  
Vol 15 (7) ◽  
pp. 571-576 ◽  
Author(s):  
Yusuf Cetin Doganer ◽  
Umit Aydogan ◽  
James Edwin Rohrer ◽  
Aydogan Aydogdu ◽  
Tuncer Cayci ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Estimated Gfr ◽  
Serum Cystatin ◽  
Artery Disease

The Ratio Serum Creatinine/Serum Cystatin C (a Surrogate Marker of Muscle Mass) as a Predictor of Hospitalization in Chronic Obstructive Pulmonary Disease Outpatients

Respiration ◽  
2018 ◽  
Vol 97 (4) ◽  
pp. 302-309 ◽  
Author(s):  
Carlos Antonio Amado ◽  
Maria Teresa García-Unzueta ◽  
Bernardo Alio Lavin ◽  
Armando Raúl Guerra ◽  
Juan Agüero ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Serum Creatinine ◽  
Pulmonary Disease ◽  
Muscle Mass ◽  
Cystatin C ◽  
Surrogate Marker ◽  
Chronic Obstructive ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Obstructive Pulmonary Disease

scholarly journals Improved Prediction of Decreased Creatinine Clearance by Serum Cystatin C: Use in Cancer Patients before and during Chemotherapy

2000 ◽  
Vol 46 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Borut Štabuc ◽  
Levin Vrhovec ◽  
Mirna Štabuc-Šilih ◽  
Tomaž Edvard Cizej
Keyword(s):  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Cancer Patients ◽  
Cystatin C ◽  
Stepwise Regression ◽  
Roc Analysis ◽  
Cysteine Protease Inhibitor ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Turbidimetric Immunoassay

Abstract Background: Serum cystatin C, a cysteine protease inhibitor, has been suggested as a new marker of glomerular filtration rate (GFR). This study explored the possibility of replacing the creatinine clearance (CrCl) estimation of GFR with cystatin C in early detection of renal impairment in cancer patients on chemotherapy. Methods: Serum creatinine and cystatin C concentrations as well as 24-h CrCl were determined simultaneously in 72 cancer patients. Among them, 60 were treated with combined chemotherapy with cisplatin (CDDP). Creatinine was determined enzymatically with a spectrophotometric method. Serum cystatin C was determined by a particle-enhanced turbidimetric immunoassay. Results: Cystatin C and creatinine correlated significantly (P = 0.001) with CrCl. The correlation was significantly better for cystatin C than creatinine (r = 0.84 vs 0.74; P = 0.01). Stepwise regression analysis identified no differences for the correlations between cystatin C and CrCl in patients with or without metastases (r = 0.82 and 0.84, respectively) as well as before treatment and before the fourth cycle of chemotherapy (r = 0.70 and 0.75, respectively). A cystatin C cutoff concentration of 1.33 mg/L had 87% sensitivity and 100% specificity for detecting CrCl <78 mL/min. ROC analysis indicated that cystatin C was superior to serum creatinine for predicting CrCl <78 mL/min (P <0.04). Conclusions: Serum cystatin C is superior to serum creatinine for detection of decreased CrCl and potentially for the estimation of GFR in cancer patients independent of the presence of metastases or chemotherapy.

scholarly journals Comparison of serum creatinine and serum cystatin C as biomarkers to detect sepsis-induced acute kidney injury and to predict mortality in CD-1 mice

2014 ◽  
Vol 307 (8) ◽  
pp. F939-F948 ◽  
Author(s):  
Asada Leelahavanichkul ◽  
Ana Carolina P. Souza ◽  
Jonathan M. Street ◽  
Victor Hsu ◽  
Takayuki Tsuji ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Cecal Ligation ◽  
Kidney Injury ◽  
Organ Damage ◽  
Experimental Sepsis ◽  
Sepsis Mortality ◽  
Serum Cystatin C ◽  
Serum Cystatin

Acute kidney injury (AKI) dramatically increases sepsis mortality, but AKI diagnosis is delayed when based on serum creatinine (SCr) changes, due in part, to decreased creatinine production. During experimental sepsis, we compared serum cystatin C (sCysC), SCr, and blood urea nitrogen (BUN) to inulin glomerular filtration rate (iGFR) before or 3–18 h after cecal ligation and puncture (CLP)-induced sepsis in CD-1 mice. sCysC had a faster increase and reached peak levels more rapidly than SCr in both sepsis and bilateral nephrectomy (BiNx) models. sCysC was a better surrogate of iGFR than SCr during sepsis. Combining sCysC with SCr values into a composite biomarker improved correlation with iGFR better than any biomarker alone or any other combination. We determined the renal contribution to sCysC handling with BiNx. sCysC and SCr were lower post-BiNx/CLP than post-BiNx alone, despite increased inflammatory and nonrenal organ damage biomarkers. Sepsis decreased CysC production in nephrectomized mice without changing body weight or CysC space. Sepsis decreased sCysC production and increased nonrenal clearance, similar to effects of sepsis on SCr. sCysC, SCr, and BUN were measured 6 h postsepsis to link AKI with mortality. Mice with above-median sCysC, BUN, or SCr values 6 h postsepsis died earlier than mice with below-median values, corresponding to a substantial AKI association with sepsis mortality in this model. sCysC performs similarly to SCr in classifying mice at risk for early mortality. We conclude that sCysC detects AKI early and better reflects iGFR in CLP-induced sepsis. This study shows that renal biomarkers need to be evaluated in specific contexts.

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