The Ratio Serum Creatinine/Serum Cystatin C (a Surrogate Marker of Muscle Mass) as a Predictor of Hospitalization in Chronic Obstructive Pulmonary Disease Outpatients

Respiration ◽  
2018 ◽  
Vol 97 (4) ◽  
pp. 302-309 ◽  
Author(s):  
Carlos Antonio Amado ◽  
Maria Teresa García-Unzueta ◽  
Bernardo Alio Lavin ◽  
Armando Raúl Guerra ◽  
Juan Agüero ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Serum Creatinine ◽  
Pulmonary Disease ◽  
Muscle Mass ◽  
Cystatin C ◽  
Surrogate Marker ◽  
Chronic Obstructive ◽  
Serum Cystatin C ◽  
Serum Cystatin ◽  
Obstructive Pulmonary Disease

scholarly journals Presarcopenia and chronic cough due to chronic obstructive pulmonary disease successfully treated with nutraceutical supplements and physical exercise

2021 ◽  
Vol 8 (4) ◽  
pp. 1
Author(s):  
Jozélio Freire De Carvalho ◽  
Aaron Lerner
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Physical Exercise ◽  
Pulmonary Disease ◽  
Muscle Mass ◽  
Chronic Cough ◽  
Laboratory Tests ◽  
Handgrip Strength ◽  
Systemic Hypertension ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Objective: To describe a patient with presarcopenia and chronic cough secondary to chronic obstructive pulmonary disease (COPD) successfully treated with supplements and physical exercise.Case report: A 75-year-old female patient with a positive past medical history of systemic hypertension, dyslipidemia, heart arrhythmia, and smoking during 20 years evolved with chronic cough due to a chronic obstructive pulmonary disease diagnosed ten years ago. She came to our private clinic due to low weight, low energy. Her weight was 44.8 kg, her height 1.57 m, body mass index of 18.18 kg/m2. Laboratory tests showed SDHEA 76.3, vitamin D of 15.6 ng/ml (nr: > 30 ng/ml), C-reactive protein (CRP) of 55 mg/ml. Computed tomography showed bronchiectasis. She had an skeletal muscle mass index of 5.0 kg/m2 (nr: > 5.5 kg/m2) by DXA. A diagnosis of presarcopenia was determined based on DXA evaluation with low muscle mass but normal gait speed handgrip strength. We suggested to the patient to increase physical exercise and prescribed a supplement formula. After five months, she returned asymptomatic, without cough, marked improvement of fatigue, increased energy levels, and weight increased to 50 kg, BMI of 20.28 kg/m2. Laboratory tests showed SDHEA to 140, vitamin D3 to 64.5 ng/ml, reduced CRP reduced to 5 mg/dl, and amlodipine was excluded due to better blood pressure control. Currently, two years later, the patient continues without cough and has dyspnea only with high efforts, without fatigue, and her weight is 52 kg and BMI 21.1 kg/m2. She also reduced her conventional treatment for COPD, using only a bronchodilator on-demand, without topical corticoids.Conclusions: This case illustrates an interesting case of a patient with presarcopenia and chronic cough, refractory to conventional approach, successfully treated with a combination of nutraceuticals and physical exercises.

scholarly journals Neuromuscular electrostimulation as an adjuvant therapy to pulmonary rehabilitation programs in chronic obstructive pulmonary disease

2020 ◽  
pp. 80-84
Author(s):  
Daniel TRĂILĂ ◽  
Camelia PESCARU ◽  
Noemi SUPPINI POROJAN ◽  
Camil MIHUTA ◽  
Patricia HOGEA ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Muscle Mass ◽  
Pulmonary Rehabilitation ◽  
Rehabilitation Program ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lower Extremity Muscle ◽  
Group B ◽  
Neuromuscular Electrostimulation

Introduction. Chronic obstructive pulmonary disease (COPD) is commonly associated with a vicious circle of sedentary lifestyle - deconditioning - muscular dysfunction. High-frequency neuromuscular electrostimulation has demonstrated beneficial effects among subjects with muscle weakness. This study aimed to evaluate the benefits of merging pulmonary rehabilitation program (PRP) with neuromuscular electrostimulation in patients with very severe COPD. Material and methods. The study included 38 males with clinically stable COPD, who were divided in 2 groups: group A-19 patients that underwent a PRP of 5 sessions/week for 4 weeks and group B-19 patients that underwent intercostal and lower extremity muscle electrostimulation (5 sessions/week for 4 weeks, 60 min /session) in association with the same type of PRP. Saint Georges’s Respiratory Questionnaire (SGRQ), Modified Medical Research Council (mMRC) dyspnea scale, spirometry, maximal inspiratory pressure (PImax) and maximal expiratory pressure (PEmax), six minutes walking test (6MWT) and bio-electrical impedance were examined before and after the intervention. Results. Electrostimulation applied in group B increased muscle mass (50.15 ± 0.61kg vs 53.97 ± 0.87kg, p<0.001)., PEmax (5.41 ± 0.25 vs post 6.79 ± 0.22, p<0.0003) and improved mMRC score (2.68 ± 0.15 vs 2.10 ± 0.15, p<0.0109), 6MWT (369.6 ± 10.77m vs post: 445.6 ± 6.03 m) and SGRQ (61.32 ± 1.83 vs. 44.95 ± 1.94, p<0.0001). In group B only SGRQ score (55.05 ± 1.32 vs. 50.05 ± 1.51, p=0.018) was improved after PRP. Conclusion. A protocol which combines PRP with neuromuscular electrical stimulation in patients with very severe forms of COPD, has grater beneficial effect on dyspnoea, exercise tolerance, muscle mass toning and quality of life, compared with PRP alone.

scholarly journals MON-LB073 The Serum Creatinine to Serum Cystatin C Ratio Is a Reliable Surrogate Marker of Sarcopenia in Patients with Cushing's Syndrome in Remission

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Luciana Martel ◽  
Helena Bascuñana ◽  
Alicia Alonso ◽  
Jordi Diaz-Manera ◽  
Jaume Llauger ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Cystatin C ◽  
Cushing’S Syndrome ◽  
Surrogate Marker ◽  
Cushing's Syndrome ◽  
Serum Cystatin C ◽  
Serum Cystatin
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