scholarly journals Inhibition of the inflammatory cytokine tumor necrosis factor-alpha with etanercept provides protection against lethal H1N1 influenza infection in mice

Critical Care ◽  
2013 ◽  
Vol 17 (6) ◽  
pp. R301 ◽  
Author(s):  
Xunlong Shi ◽  
Wei Zhou ◽  
Hai Huang ◽  
Hongguang Zhu ◽  
Pei Zhou ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Inflammatory Cytokine ◽  
Influenza Infection ◽  
H1n1 Influenza ◽  
Necrosis Factor Alpha ◽  
Cytokine Tumor Necrosis Factor ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals The effect of the pro-inflammatory cytokine tumor necrosis factor-alpha on human joint capsule myofibroblasts

2010 ◽  
Vol 12 (1) ◽  
pp. R4 ◽  
Author(s):  
Stefan G Mattyasovszky ◽  
Alexander Hofmann ◽  
Christoph Brochhausen ◽  
Ulrike Ritz ◽  
Sebastian Kuhn ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Inflammatory Cytokine ◽  
Joint Capsule ◽  
Necrosis Factor Alpha ◽  
Cytokine Tumor Necrosis Factor ◽  
Factor Alpha ◽  
Necrosis Factor ◽  
Human Joint

scholarly journals INFLUENCE OF AUTOLEUKOCYTE VACCINATION ON ACTIVITY LEVEL OF TUMOR NECROSIS FACTOR ALPHA IN PATIENTS WITH CHRONIC HEPATITIS B

2019 ◽  
Vol 72 (1) ◽  
pp. 31-34
Author(s):  
Alexandr Zinchuk ◽  
Oleksandr Herasun ◽  
Andrij Zadorozhnyi ◽  
Olga Vorozhbyt ◽  
Borys Gerasun
Keyword(s):  
Chronic Hepatitis ◽  
Tumor Necrosis Factor ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Inflammatory Cytokine ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Introduction: data about influence of intradermal vaccination with native autoleukocytes on activity level of pro-inflammatory cytokine tumor necrosis factor alpha in patients with chronic hepatitis B have been presented in the article. The aim: Based on positive results, obtained from autoleukocyte immunization in patients with psoriasis [14], the aim of our research was to use and study such therapy for reducing the synthesis of pro-inflammatory cytokine TNF-α in patients with chronic hepatitis B (chronic hepatitis B). Materials and methods: Patients with chronic hepatitis B with high level of tumor necrosis factor alpha (≥30pg/ml) were vaccinated with native autoleukocytes (23); simultaneously, the same procedure was performed to patients (11) with low level of this cytokine (5pg/ml). Leukocytes were isolated from heparinized peripheral venous blood of a patient with hepatitis B by centrifuging plasma, obtained after blood precipitation for 140-160 minutes at temperature 370 С. The suspension was resuspended in 1-1.5 ml of a patient’s blood serum and injected into the skin of the back in the dose 0.1 ml. Results: in 30 days after immunization, reduction of tumor necrosis factor alpha was observed in all patients with its high level (100%), in 65.25% of individuals – to 5 pg/ml; in some patients, who had low or average level of pro-inflammatory cytokine, the level individually increased (41.67%). Conclusions: The elaborated method of influence on activity of tumor necrosis factor alpha in patients with chronic hepatitis B is effective and worth implementing into clinical practice.

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