scholarly journals The Effect of Endotoxin on the Liver Lipid Peroxide Level and on the Liver and Plasma Zinc Concentrations in Rats As Related to Time After Administration

1982 ◽  
Vol 23 (1) ◽  
pp. 24-29
Author(s):  
Satu Sankari ◽  
Timo Pekkanen
Keyword(s):  
Liver Lipid ◽  
Lipid Peroxide ◽  
Plasma Zinc ◽  
Lipid Peroxide Level ◽  
Zinc Concentrations

scholarly journals Hepatic Lipid Peroxide Profile on Inflamation Rats with Nanocurcuminoid Treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Waras Nurcholis ◽  
Chelsea ◽  
Laksmi Ambarsari
Keyword(s):  
Free Radicals ◽  
Palmitic Acid ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Hepatic Lipid ◽  
Lipid Peroxide Level ◽  
Average Size ◽  
532 Nm

Inflammation can cause the formation of prostaglandin and free radicals. In addition, overcome inflammation, a drug used also needs to have an effect as antioxidants to treat the free radicals. This problem can be solved by curcuminoid nanoparticles covered with palmitic acid. This research aims to test the antioxidants effect of curcuminoid nanoparticles covered with palmitic acid from Curcuma to lipid peroxide levels on inflammation rats liver. Antioxidants effect of nanocurcuminoid tested on rats that induced by 1% carrageenan and the liver lipid peroxide measured after 24 hours. Lipid peroxide level was measured with a spectrophotometer in 532 nm wavelength. The average size of curcuminoid nanoparticle covered with palmitic acid is 561.53 nm with an IP score of 0.309. Lipid peroxide level of inflammation rats liver given curcuminoids extract 100 mg/kg BW is 0.27x10-4 nmol/g. It was lower from the nanocurcuminoids 250 mg/kg BW groups which are 1.22 x10-4 nmol/g. Nanocurcuminoids 250 mg/kg BW is 114 times more efficient as an antioxidant than curcuminoids extract 100 mg/kg BW. Keywords: antioxidant, lipid peroxide, nanocurcuminoids

scholarly journals Effect of Catecholestrogens on Mortality and Liver Lipid Peroxide Level of Mice Irradiated with 60Co .GAMMA.-Ray.

1993 ◽  
Vol 15 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Akira TOMATSU ◽  
Sadaaki KOMURA ◽  
Nobuko OHISHI ◽  
Masami NAKANISHI ◽  
Kunio YAGI
Keyword(s):  
Gamma Ray ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Lipid Peroxide Level ◽  
60Co Gamma

Plasma zinc concentrations of breast-fed infants

1979 ◽  
Vol 94 (4) ◽  
pp. 607-608 ◽  
Author(s):  
K. Michael Hambidge ◽  
Philip A. Walravens ◽  
Clare E. Casey ◽  
Ronald M. Brown ◽  
Connie Bender
Keyword(s):  
Plasma Zinc ◽  
Zinc Concentrations ◽  
Breast Fed

Enteropathic acrodermatitis in children

2021 ◽  
Vol 11 (2) ◽  
pp. 21-28
Author(s):  
V.P. Novikova ◽  
◽  
A.A. Pokhlebkina ◽  
D.V. Zaslavsky ◽  
A.I. Khavkin ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Topical Therapy ◽  
Clinical Manifestations ◽  
Skin Lesions ◽  
Knee Joints ◽  
Zinc Metabolism ◽  
Plasma Zinc ◽  
Significant Treatment ◽  
Zinc Concentrations ◽  
Erythematous Plaques

Enteropathic acrodermatitis is a rare hereditary form of zinc deficiency, characterized by periorial and acral dermatitis, alopecia and diarrhea. Refers to congenital disorders of zinc metabolism, inherited as an autosomal recessive disease resulting from mutations in the gene for the zinc transporter SLC39A4. The prevalence ranges from 1 to 9:1,000,000, with an overall incidence of 1:500,000 newborns. The disease usually manifests itself in infancy, within a few weeks of stopping breastfeeding and switching the baby to a cow's milk-based formula, or in the first days of life if artificially fed from birth. The classical clinical manifestations of acrodermatitis enteropathic are characterized by the triad: acral and periofital dermatitis, alopecia and diarrhea, but all three signs together occur only in 20% of cases. Diarrhea may develop concurrently with skin symptoms, may precede or occur later. Characteristic signs of skin lesions include sharply demarcated, dry, scaly erythematous plaques or edematous foci with vesicles and pustules on the skin of the elbow and knee joints, distal extremities, genitals, in the inguinal folds, which are usually symmetrically distributed, have sharp boundaries and irregular outlines. The course of the skin syndrome is long, as it progresses, non-healing erosive and ulcerative areas appear. Plasma zinc deficiency is the gold standard for diagnosis. Most infants with AE have low plasma zinc concentrations (<500 mcg/L or <50 mcg/dl), but a level of less than 70 mcg/L on an empty stomach or less than 65 mcg/dl in older non-dieting children is considered diagnostically significant. Treatment for this disease usually includes enteral or parenteral zinc administration, at a dose of 1-3 mg/kg/day. for elemental zinc. A clinical response is observed within 5–10 days. Supportive zinc therapy is necessary throughout the patient's life, although periods of remission have been reported. Topical therapy is also used: Dexpanthenol in the form of a cream, applied 3 times a day in the area of dermatitis, can enhance re-epithelialization. There is no significant evidence of improvement with topical zinc application. No activity restrictions are required for patients with acrodermatitis enteropathic. Key words: zinc deficiency, enteropathic acrodermatitis, children

Zinc Deficiency and Edema

PEDIATRICS ◽  
1986 ◽  
Vol 77 (1) ◽  
pp. 132-133
Author(s):  
MICHAEL H. N. GOLDEN ◽  
BARBARA E. GOLDEN
Keyword(s):  
Developing Countries ◽  
Zinc Deficiency ◽  
Premature Infants ◽  
Zinc Concentration ◽  
Clinical Presentation ◽  
Plasma Zinc ◽  
Plasma Zinc Concentration ◽  
Clear Association ◽  
Zinc Concentrations

To the Editor.— Kumar and Anday1 describe three premature infants presenting with edema and hypoproteinemia—the classical signs of kwashiorkor—between 5 and 9 weeks of age. Such cases are not uncommon in developing countries. Kumar and Anday's patients had low plasma zinc concentrations (43, 37, and 42 µg/dL). On this basis the authors claim that edema and hypoproteinemia is a clinical presentation of zinc deficiency not previously reported. We reported2 a clear association between "nutritional" edema and a low plasma zinc concentration in 1979; our subsequent experience has confirmed that edema of this type is always associated with a low plasma zinc concentration, as indeed Kumar and Andays' cases demonstrate.

Low plasma zinc concentrations in young infants with cystic fibrosis

1998 ◽  
Vol 133 (6) ◽  
pp. 761-764 ◽  
Author(s):  
Nancy F. Krebs ◽  
Marci Sontag ◽  
Frank J. Accurso ◽  
K.Michael Hambidge
Keyword(s):  
Cystic Fibrosis ◽  
Plasma Zinc ◽  
Young Infants ◽  
Zinc Concentrations

Changes in plasma zinc content after exercise in men fed a low-zinc diet

1984 ◽  
Vol 247 (1) ◽  
pp. E88-E93 ◽  
Author(s):  
H. C. Lukaski ◽  
W. W. Bolonchuk ◽  
L. M. Klevay ◽  
D. B. Milne ◽  
H. H. Sandstead
Keyword(s):  
Copper Content ◽  
Maximal Exercise ◽  
Strong Predictor ◽  
Zinc Content ◽  
Plasma Zinc ◽  
Zinc Depletion ◽  
Plasma Copper ◽  
Zinc Concentrations ◽  
Zinc Repletion ◽  
Zinc Balance

For 30 days five healthy men aged 23-57 yr consumed a diet adequate in zinc (8.6 mg/day); they ate a low-zinc diet (3.6 mg/day) for the next 120 days and then received a zinc-supplemented (33.6 mg/day) diet for 30 days. Copper intake was constant at 1.8 mg/day. Aerobic capacity was determined periodically during each diet period. Relative zinc balance (% of control) declined during depletion (r = -0.28, P less than 0.009). Pre- and postexercise zinc concentrations decreased when dietary zinc was restricted (r = -0.61, P less than 0.0001 and r = -0.78, P less than 0.0001) and increased with supplementation (r = 0.61, P less than 0.008 and r = 0.76, P less than 0.0003, respectively). Both plasma zinc and hematocrit increased (P less than 0.01) after maximal exercise. To minimize the effect of hemoconcentration during exercise, the van Beaumont quotient (J. Appl. Physiol. 34: 102-106, 1973) was calculated using pre- and postexercise hematocrit and plasma zinc. The initial quotient of 1.8 +/- 1.8% (mean +/- SE) declined (P less than 0.05) to -7.4 +/- 2.3% during depletion. With zinc repletion, the quotient increased to 6.9 +/- 3.6%, which was greater (P less than 0.05) than the quotient in depletion but similar to the initial quotient. The quotient was a strong predictor (r = 0.71, P less than 0.0005) of the change in relative zinc balance during zinc depletion. In contrast, no changes were found in plasma copper content. These data suggest that zinc mobilization from tissues is impaired during zinc depletion, and they validate the use of the van Beaumont quotient as an index of change in body zinc stores.

The effect of epidermal growth factor on liver lipid peroxidation and glutathione levels in lobectomized rats

1992 ◽  
Vol 70 (3-4) ◽  
pp. 259-262 ◽  
Author(s):  
Nahide Gokcora ◽  
Sadi Gundogdu ◽  
Aysel Aricioglu ◽  
Deniz Erbas ◽  
Osman Durmus ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Liver Lipid ◽  
Lipid Peroxide ◽  
Submaxillary Gland ◽  
Control Group ◽  
Key Factor ◽  
Male Wistar Rats ◽  
Epidermal Growth

Epidermal growth factor (EGF) is a growth-promoting polypeptide which is found in highest levels in male mice in the submaxillary gland. It may also be a key factor in regeneration of the liver. We performed experiments with 18 male Wistar rats, divided into three groups. Hepatic left lobectomy (%30) was performed on the first group of rats. This group received an intraperitoneal injection of EGF for 7 days. The second group was the control group into which normal saline was injected for 7 days. The third group was sham-operated. On days 5 and 7 tomographic studies of liver were performed. On day 7 EGF levels, lipid peroxidation, and glutathione in liver were measured in all of the rats. While serum EGF levels did not show any significant change, the levels of lipid peroxide were decreased and glutathione was increased. Tomographic measurements indicated that administration of EGF increased the amount of regeneration.Key words: epidermal growth factor, liver lobectomy, lipid peroxide, glutathione, radioimmunoassay.

Measurement of Hypozincaemia in Mice: A Sensitive Test for Detection of Pyrogens

1981 ◽  
Vol 61 (4) ◽  
pp. 445-449 ◽  
Author(s):  
Susan Boobis ◽  
Rose E. Hartley
Keyword(s):  
Escherichia Coli ◽  
Zinc Concentration ◽  
Shigella Dysenteriae ◽  
Metabolic Inhibitor ◽  
Repeated Treatment ◽  
Plasma Zinc ◽  
Sensitive Test ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Dose Dependent

1. The effect of bacterial pyrogens on plasma zinc concentration in mice was studied as a method of bioassay for these substances. 2. A dose-related depression of plasma zinc concentrations was observed 4 h after intravenous injection of doses of 0.05-500 ng of purified endotoxins of Salmonella abortus equi, Shigella dysenteriae and Escherichia coli. Responses were dose-dependent and reproducible for each endotoxin in five strains of mice. 3. Tolerance to endotoxin could be induced in mice by injection of doses of 500 ng but was not seen with doses of <5 ng, even after repeated treatment. 4. Dinitrophenol, a metabolic inhibitor, and amphetamine, a metabolic enhancer, did not affect plasma zinc levels, indicating that changes in basal metabolic rate do not affect the outcome of this assay. The effects of pyrogenic materials other than endotoxin on plasma zinc levels were also tested and the results suggest that measurement of hypozincaemia in mice provides the basis for a simple, practical and inexpensive test for endotoxins and other pyrogens.

Sign in / Sign up

Export Citation Format

Share Document