scholarly journals Future possibilities in the prevention of breast cancer: Role of genetic variation in breast cancer prevention

10.1186/bcr69 ◽  
2000 ◽  
Vol 2 (4) ◽  
Author(s):  
Heather Spencer Feigelson ◽  
Brian E Henderson
Keyword(s):  
Breast Cancer ◽  
Genetic Variation ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Prevention Of Breast Cancer

scholarly journals Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets

2016 ◽  
Vol 9 ◽  
pp. NMI.S39043 ◽  
Author(s):  
Salma A. Abdelmagid ◽  
Jessica L. MacKinnon ◽  
Sarah M. Janssen ◽  
David W.L. Ma
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Future Research ◽  
Pufa Intake ◽  
Diet And Exercise ◽  
Important Study

Diet and exercise are recognized as important lifestyle factors that significantly influence breast cancer risk. In particular, dietary n-3 polyunsaturated fatty acids (PUFAs) have been shown to play an important role in breast cancer prevention. Growing evidence also demonstrates a role for exercise in cancer and chronic disease prevention. However, the potential synergistic effect of n-3 PUFA intake and exercise is yet to be determined. This review explores targets for breast cancer prevention that are common between n-3 PUFA intake and exercise and that may be important study outcomes for future research investigating the combined effect of n-3 PUFA intake and exercise. These lines of evidence highlight potential new avenues for research and strategies for breast cancer prevention.

Mammary stem cells: the root of breast cancer?

2004 ◽  
Vol 7 (9) ◽  
Author(s):  
H. A. Coppock ◽  
R. B. Clarke
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mammary Gland ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Differentiated Cells ◽  
Mammary Stem ◽  
Tissue Specific Stem Cells ◽  
Prevention And Therapy

Tissue-specific stem cells play a key role in organ homoeostasis. They are relatively well characterized in systems which undergo constant proliferation and production of differentiated cells, including the haemopoietic system, skin and intestine. However, little is known about the role and regulation of stem cells in the mammary gland. This review briefly summarizes the current understanding of the role of breast-specific stem cells in normal and cancerous tissues, and how this may identify new targets for breast cancer prevention and therapy.

scholarly journals The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives

Breast Care ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. 339-344 ◽  
Author(s):  
Demetrios Moris ◽  
Michalis Kontos ◽  
Eleftherios Spartalis ◽  
Ian S. Fentiman
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Large Scale ◽  
Clinical Investigation ◽  
Breast Cancer Incidence ◽  
Breast Cancer Prevention ◽  
Current Evidence ◽  
Dose Frequency ◽  
Chemopreventive Agents

Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have received considerable interest as potential chemopreventive agents. The aim of this review is to summarize the accumulated knowledge on the effect of NSAIDs on breast cancer incidence and natural history, and the underlying pathophysiology. NSAIDs mainly block inflammation by inhibiting cyclooxygenase enzymes, leading to lower prostaglandin synthesis. The latter has been reported to affect breast cancer risk through hormonal and inflammation-related pathways. Intensity, dose, frequency, duration, and timing of administration may also be significant. There is currently enough evidence to support a role of NSAIDs in breast cancer prevention and relapse, which deserves further large-scale experimental and clinical investigation.

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