scholarly journals The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives

Breast Care ◽  
2016 ◽  
Vol 11 (5) ◽  
pp. 339-344 ◽  
Author(s):  
Demetrios Moris ◽  
Michalis Kontos ◽  
Eleftherios Spartalis ◽  
Ian S. Fentiman
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Large Scale ◽  
Clinical Investigation ◽  
Breast Cancer Incidence ◽  
Breast Cancer Prevention ◽  
Current Evidence ◽  
Dose Frequency ◽  
Chemopreventive Agents

Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have received considerable interest as potential chemopreventive agents. The aim of this review is to summarize the accumulated knowledge on the effect of NSAIDs on breast cancer incidence and natural history, and the underlying pathophysiology. NSAIDs mainly block inflammation by inhibiting cyclooxygenase enzymes, leading to lower prostaglandin synthesis. The latter has been reported to affect breast cancer risk through hormonal and inflammation-related pathways. Intensity, dose, frequency, duration, and timing of administration may also be significant. There is currently enough evidence to support a role of NSAIDs in breast cancer prevention and relapse, which deserves further large-scale experimental and clinical investigation.

The role of Vitamin D3 in breast cancer prevention: A literature review

2021 ◽  
Vol 59 (1) ◽  
pp. 47-50
Author(s):  
B. K. Tarakova ◽  
A. S. Kultayev ◽  
S. E. Yessentayeva
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Vitamin D3 ◽  
Breast Cancer Incidence ◽  
Breast Cancer Prevention ◽  
Cancer Pathogenesis ◽  
Literature Reviews ◽  
Chemotherapy Agents ◽  
High Treatment

Breast cancer is one of the most common malignancies with a high mortality rate worldwide, including in Kazakhstan. Despite modern advanced di-agnosis and treatment methods, breast cancer remains one of the top three “killer cancers.” Treatment with immunoglobulins and modern targeted chemotherapy agents is efficient but does not reduce breast cancer incidence. High treatment cost, antitumor drug resistance occurring during therapy, and significant side ef-fects of chemotherapy urge the importance of prophylactic actions to prevent the tumor disease. The purpose of the study was to review the Vitamin D3 role and potential in breast cancer prevention. Results: The analysis of the literature reviews and original articles accessing the Vitamin D3 role in breast cancer pathogenesis and the study of the main anti-tumor mechanisms of Vitamin D3 action emphasize the need for large randomized prospective studies to determine the actual Vitamin D3 role in breast cancer pathogenesis and its possible inclusion in antitumor therapy regimens. Conclusion: The results obtained evidence on the Vitamin D3 adjuvant potential in breast cancer treatment.

scholarly journals The role of Vitamin D3 in breast cancer prevention: A literature review

2021 ◽  
Vol 59 (1) ◽  
pp. 47-50
Author(s):  
B. Tarakova ◽  
Askhat Kultayev ◽  
Suriya Yessentayeva
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Vitamin D3 ◽  
Breast Cancer Incidence ◽  
Breast Cancer Prevention ◽  
Cancer Pathogenesis ◽  
Literature Reviews ◽  
Chemotherapy Agents ◽  
High Treatment

Relevance: Breast cancer is one of the most common malignancies with a high mortality rate all over the world, including Kazakhstan. Despite modern advanced diagnosis and treatment methods, breast cancer remains one of the top three «killer cancers.» Treatment with immunoglobulins and modern targeted chemotherapy agents is efficient but does not reduce the breast cancer incidence. High treatment cost, antitumor drug resistance occurring during therapy, and significant side effects of chemotherapy urge the importance of prophylactic actions able to prevent the tumor disease. Purpose: To review the Vitamin D3 role and potential in breast cancer prevention. Results: The analysis of the literature reviews and original articles accessing the Vitamin D3 role in breast cancer pathogenesis and the study of the main antitumor mechanisms of Vitamin D3 action emphasize the need for large randomized prospective studies to determine the actual Vitamin D3 role in breast cancer pathogenesis and its possible inclusion in antitumor therapy regimens. Conclusion: The results obtained evidence the Vitamin D3 adjuvant potential in breast cancer treatment

scholarly journals Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets

2016 ◽  
Vol 9 ◽  
pp. NMI.S39043 ◽  
Author(s):  
Salma A. Abdelmagid ◽  
Jessica L. MacKinnon ◽  
Sarah M. Janssen ◽  
David W.L. Ma
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Future Research ◽  
Pufa Intake ◽  
Diet And Exercise ◽  
Important Study

Diet and exercise are recognized as important lifestyle factors that significantly influence breast cancer risk. In particular, dietary n-3 polyunsaturated fatty acids (PUFAs) have been shown to play an important role in breast cancer prevention. Growing evidence also demonstrates a role for exercise in cancer and chronic disease prevention. However, the potential synergistic effect of n-3 PUFA intake and exercise is yet to be determined. This review explores targets for breast cancer prevention that are common between n-3 PUFA intake and exercise and that may be important study outcomes for future research investigating the combined effect of n-3 PUFA intake and exercise. These lines of evidence highlight potential new avenues for research and strategies for breast cancer prevention.

scholarly journals An Expanded Agenda for the Primary Prevention of Breast Cancer: Charting a Course for the Future

2020 ◽  
Vol 17 (3) ◽  
pp. 714 ◽  
Author(s):  
Mary C. White ◽  
Marion (Mhel) H. E. Kavanaugh-Lynch ◽  
Shauntay Davis-Patterson ◽  
Nancy Buermeyer
Keyword(s):  
Breast Cancer ◽  
United States ◽  
Cancer Prevention ◽  
Cancer Diagnosis ◽  
Cancer Incidence ◽  
Cancer Survival ◽  
Breast Cancer Incidence ◽  
The United States ◽  
Breast Cancer Prevention ◽  
The Future

Advances in breast cancer science, early detection, and treatment have resulted in improvements in breast cancer survival but not in breast cancer incidence. After skin cancer, breast cancer is the most common cancer diagnosis in the United States. Each year, nearly a quarter million U.S. women receive a breast cancer diagnosis, and the number continues to rise each year with the growth in the population of older women. Although much remains to be understood about breast cancer origins and prevention, action can be taken on the existing scientific knowledge to address the systemic factors that drive breast cancer risk at the population level. The California Breast Cancer Research Program funded a team at Breast Cancer Prevention Partners (BCPP) to convene leaders in advocacy, policy, and research related to breast cancer prevention from across the state of California. The objective was the development of a strategic plan to direct collective efforts toward specific and measurable objectives to reduce the incidence of breast cancer. The structured, innovative approach used by BCPP to integrate scientific evidence with community perspectives provides a model for other states to consider, to potentially change the future trajectory of breast cancer incidence in the United States.

Mammary stem cells: the root of breast cancer?

2004 ◽  
Vol 7 (9) ◽  
Author(s):  
H. A. Coppock ◽  
R. B. Clarke
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mammary Gland ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Differentiated Cells ◽  
Mammary Stem ◽  
Tissue Specific Stem Cells ◽  
Prevention And Therapy

Tissue-specific stem cells play a key role in organ homoeostasis. They are relatively well characterized in systems which undergo constant proliferation and production of differentiated cells, including the haemopoietic system, skin and intestine. However, little is known about the role and regulation of stem cells in the mammary gland. This review briefly summarizes the current understanding of the role of breast-specific stem cells in normal and cancerous tissues, and how this may identify new targets for breast cancer prevention and therapy.

Sign in / Sign up

Export Citation Format

Share Document