scholarly journals Aldehyde dehydrogenase and estrogen receptor define a hierarchy of cellular differentiation in the normal human mammary epithelium

2014 ◽  
Vol 16 (3) ◽  
Author(s):  
Gabriella Honeth ◽  
Sara Lombardi ◽  
Christophe Ginestier ◽  
Minhee Hur ◽  
Rebecca Marlow ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Aldehyde Dehydrogenase ◽  
Cellular Differentiation ◽  
Mammary Epithelium ◽  
Human Mammary Epithelium ◽  
Normal Human

scholarly journals Normal breast epithelial MCF-10A cells to evaluate the safety of carbon dots

2021 ◽  
Author(s):  
Nuno Vale ◽  
Sara Silva ◽  
Diana Duarte ◽  
Diana M. A. Crista ◽  
Luís Pinto da Silva ◽  
...  
Keyword(s):  
Cell Line ◽  
Carbon Dots ◽  
Mammary Epithelium ◽  
Structural Similarity ◽  
Normal Breast ◽  
Breast Cell Line ◽  
Toxicity Studies ◽  
Human Mammary Epithelium ◽  
Normal Human ◽  
Breast Epithelial

The human normal breast cell line MCF-10A is being widely used as a model in toxicity studies due to its structural similarity to the normal human mammary epithelium.

scholarly journals A Novel Method for Growing Human Breast Epithelium in Vivo Using Mouse and Human Mammary Fibroblasts

Endocrinology ◽  
2002 ◽  
Vol 143 (12) ◽  
pp. 4886-4896 ◽  
Author(s):  
Hema Parmar ◽  
Peter Young ◽  
Joanne T. Emerman ◽  
Richard M. Neve ◽  
Shanaz Dairkee ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Nude Mice ◽  
Milk Fat ◽  
Mammary Epithelium ◽  
Collagen Gels ◽  
Human Breast ◽  
Human Mammary Gland ◽  
Human Mammary Epithelium ◽  
Normal Human

Abstract A novel system is described for studying the growth of normal human mammary epithelium in vivo as grafts in athymic nude mice. The key feature of this model is reconstitution of the epithelial-stromal interactions required for normal growth and differentiation of the human mammary epithelium, which produces ducts that are comparable to those in the normal human mammary gland. Human breast epithelial organoids were combined with mammary fibroblasts from mouse or human origin in collagen gels, which were subsequently transplanted under the renal capsule of female nude mice hosts. The resulting grafts showed an increase in the ductal density compared with that observed previously. These ducts expressed appropriate markers for luminal and myoepithelial cells and steroid receptors. Treatment of the host with diethylstilbestrol or estradiol and progesterone significantly increased the number of ducts observed and increased cell proliferation. The grafts also displayed production of β-casein and milk fat globule membrane protein when the hosts were allowed to become pregnant. This model allows for a variety of epithelial and stromal cells to be used in combination, which would aid in understanding key factors that regulate normal human mammary gland development.

scholarly journals Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium.

1987 ◽  
Vol 84 (17) ◽  
pp. 6060-6064 ◽  
Author(s):  
S. J. Gendler ◽  
J. M. Burchell ◽  
T. Duhig ◽  
D. Lamport ◽  
R. White ◽  
...  
Keyword(s):  
Mammary Epithelium ◽  
Mucin Glycoproteins ◽  
Human Mammary Epithelium ◽  
Partial Cdna

scholarly journals Identification of Wild-Type and Exon 5 Deletion Variants of Estrogen Receptor β in Normal Human Mammary Gland1

2000 ◽  
Vol 85 (4) ◽  
pp. 1601-1605 ◽  
Author(s):  
Valerie Speirs ◽  
Ian P. Adams ◽  
David S. Walton ◽  
Stephen L. Atkin
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Β ◽  
Wild Type ◽  
Normal Human
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