scholarly journals The effect of versican G3 domain on local breast cancer invasiveness and bony metastasis

2007 ◽  
Vol 9 (4) ◽  
Author(s):  
Albert JM Yee ◽  
Margarete Akens ◽  
Bing L Yang ◽  
Joel Finkelstein ◽  
Peng-Sheng Zheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bony Metastasis ◽  
Cancer Invasiveness ◽  
Breast Cancer Invasiveness

scholarly journals TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasiveness

Oncogene ◽  
2020 ◽  
Vol 39 (22) ◽  
pp. 4436-4449 ◽  
Author(s):  
Anders Sundqvist ◽  
Eleftheria Vasilaki ◽  
Oleksandr Voytyuk ◽  
Yu Bai ◽  
Masato Morikawa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Transcriptional Regulation ◽  
Cancer Invasiveness ◽  
Breast Cancer Invasiveness ◽  
Egf Signaling

Diffusion-weighted imaging using ADC mapping as an imaging biomarker for breast cancer invasiveness.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 11093-11093
Author(s):  
Hubert Bickel ◽  
Wolfgang Bogner ◽  
Peter Christian Dubsky ◽  
Rupert Bartsch ◽  
Margaretha Rudas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diffusion Weighted Imaging ◽  
Malignant Tumors ◽  
Imaging Biomarker ◽  
Benign Tumors ◽  
Non Invasive ◽  
Diffusion Weighted ◽  
Cancer Invasiveness ◽  
Adc Values ◽  
Breast Cancer Invasiveness

11093 Background: Recently, functional imaging techniques such as diffusion weighted imaging (DWI) have been added to routine MR and have shown great potential for improving breast cancer diagnosis. DWI depicts cellular diffusivity on a molecular level and can be quantified using the apparent diffusion coefficient (ADC). In malignant tumors diffusivity is restricted, leading to lower ADC values than benign tumors. The aim of this study was to proof, that DWI can be used to differentiate benign from malignant tumors and to elucidate if ADC can serve as an imaging biomarker for breast cancer invasiveness. Methods: In this IRB-approved study 250 patients with 267 suspicious breast lesions (BI-RADS IV-V) were included. All patients underwent routine MR at 3T. A DWI-sequence was added to a standard imaging protocol, increasing measurement time by 2:30 min. The lesions were identified in routine MR and DWI sequences and ADC values of the lesions were calculated. Histopathology was used as the standard of reference for all lesions. Appropriate statistical tests were used to compare the ADC values of benign and malignant tumors (cut-off value 1.25×10-3mm²/s), of invasive and non-invasive disease and between different invasive tumor subtypes. Results: There were 91 benign (mean ADC 1.58×10-3mm²/s) and 176 malignant (.94×10-3mm²/s) lesions, sensitivity and specificity were 94.3% (PPV 95.4%, CI 0.91-0.98) and 91.2% (NPV 89.2%, CI 0.81-0.94). 155 lesions were invasive cancers (median ADC .90×10-3mm²/s), while 21 were non-invasive ductal carcinoma in situ (1.22×10-3mm²/s). The invasive cancers were 130 invasive ductal (median ADC .91×10-3mm²/s) and 25 invasive lobular cancers (.83×10-3mm²/s). ADC was significantly different between benign and malignant lesions (p<.001) and between invasive and non-invasive cancers (p<.001), while no significant difference could be found between the invasive cancer subtypes (p=.163). Conclusions: Diffusion-weighted imaging reliably allows differentiation of benign and malignant breast tumors. The data suggest that ADC can be used as a non-invasive imaging biomarker for breast cancer invasiveness and may be of importance to treatment planning and outcome in breast cancer patients.

scholarly journals Estrogen receptor-α regulation of microRNA-590 targets FAM171A1—a modifier of breast cancer invasiveness

Oncogenesis ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Rahul Sanawar ◽  
Vipin Mohan Dan ◽  
Thankayyan R. Santhoshkumar ◽  
Rakesh Kumar ◽  
M. Radhakrishna Pillai
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Cancer Invasiveness ◽  
Breast Cancer Invasiveness

scholarly journals Role of thrombin receptor in breast cancer invasiveness

1999 ◽  
Vol 79 (3-4) ◽  
pp. 401-406 ◽  
Author(s):  
K P Henrikson ◽  
S L Salazar ◽  
J W Fenton ◽  
B T Pentecost
Keyword(s):  
Breast Cancer ◽  
Thrombin Receptor ◽  
Cancer Invasiveness ◽  
Breast Cancer Invasiveness
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