scholarly journals Prostasin serine protease inhibits breast cancer invasiveness and is transcriptionally regulated by promoter DNA methylation

2001 ◽  
Vol 97 (3) ◽  
pp. 323-329 ◽  
Author(s):  
Li-Mei Chen ◽  
Karl X. Chai
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Serine Protease ◽  
Promoter Dna Methylation ◽  
Cancer Invasiveness ◽  
Breast Cancer Invasiveness ◽  
Promoter Dna

scholarly journals Computational Detection of Breast Cancer Invasiveness with DNA Methylation Biomarkers

Cells ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 326 ◽  
Author(s):  
Chunyu Wang ◽  
Ning Zhao ◽  
Linlin Yuan ◽  
Xiaoyan Liu
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Clinical Decision Making ◽  
Metastatic Cancer ◽  
The Cancer Genome Atlas ◽  
Cancer Data ◽  
Potential Biomarker ◽  
Cancer Aggressiveness ◽  
Cancer Invasiveness ◽  
Breast Cancer Invasiveness

Breast cancer is the most common female malignancy. It has high mortality, primarily due to metastasis and recurrence. Patients with invasive and noninvasive breast cancer require different treatments, so there is an urgent need for predictive tools to guide clinical decision making and avoid overtreatment of noninvasive breast cancer and undertreatment of invasive cases. Here, we divided the sample set based on the genome-wide methylation distance to make full use of metastatic cancer data. Specifically, we implemented two differential methylation analysis methods to identify specific CpG sites. After effective dimensionality reduction, we constructed a methylation-based classifier using the Random Forest algorithm to categorize the primary breast cancer. We took advantage of breast cancer (BRCA) HM450 DNA methylation data and accompanying clinical data from The Cancer Genome Atlas (TCGA) database to validate the performance of the classifier. Overall, this study demonstrates DNA methylation as a potential biomarker to predict breast tumor invasiveness and as a possible parameter that could be included in the studies aiming to predict breast cancer aggressiveness. However, more comparative studies are needed to assess its usability in the clinic. Towards this, we developed a website based on these algorithms to facilitate its use in studies and predictions of breast cancer invasiveness.

scholarly journals Differential Prognostic Relevance of Promoter DNA Methylation of CDO1 and HOPX in Primary Breast Cancer

2019 ◽  
Vol 39 (5) ◽  
pp. 2289-2298 ◽  
Author(s):  
YOKO TANAKA ◽  
YOSHIMASA KOSAKA ◽  
MINA WARAYA ◽  
KAZUKO YOKOTA ◽  
HIROKI HARADA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Primary Breast Cancer ◽  
Prognostic Relevance ◽  
Promoter Dna Methylation ◽  
Promoter Dna
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