scholarly journals A targeted lipidomics approach to the study of eicosanoid release in synovial joints

2011 ◽  
Vol 13 (4) ◽  
pp. R123 ◽  
Author(s):  
Janny C de Grauw ◽  
Chris HA van de Lest ◽  
Paul van Weeren
2014 ◽  
Vol 199 (5-6) ◽  
pp. 364-372 ◽  
Author(s):  
M. Rita Correro-Shahgaldian ◽  
Chafik Ghayor ◽  
Nicholas D. Spencer ◽  
Franz E. Weber ◽  
Luigi M. Gallo

1995 ◽  
Vol 61 (588) ◽  
pp. 3396-3401 ◽  
Author(s):  
Hidehiko Higaki ◽  
Teruo Murakami ◽  
Yoshitaka Nakanishi
Keyword(s):  

1956 ◽  
Vol 31 (8) ◽  
pp. 353-364 ◽  
Author(s):  
M. A. MacConaill
Keyword(s):  

1977 ◽  
Vol 99 (2) ◽  
pp. 163-172 ◽  
Author(s):  
Joseph M. Mansour ◽  
Van C. Mow

Fluid flow and mass transport mechanisms associated with articular cartilage function are important biomechanical processes of normal and pathological synovial joints. A three-layer permeable, two-phase medium of an incompressible fluid and a linear elastic solid are used to model the flow and deformational behavior of articular cartilage. The frictional resistance of the relative motion of the fluid phase with respect to the solid phase is given by a linear diffusive dissipation term. The subchondral bony substrate is represented by an elastic solid. The three-layer model of articular cartilage is chosen because of the known histological, ultrastructural, and biomechanical variations of the tissue properties. The calculated flow field shows that for material properties of normal healthy articular cartilage the tissue creates a naturally lubricated surface. The movement of the interstitial fluid at the surface is circulatory in manner, being exuded in front and near the leading half of the moving surface load and imbibed behind and near the trailing half of the moving load. The flow fields of healthy tissues are capable of sustaining a film of fluid at the articular surface whereas pathological tissues cannot.


1997 ◽  
Vol 9 (3) ◽  
pp. 255-271 ◽  
Author(s):  
Michael J. Furey ◽  
Bettina M. Burkhardt
Keyword(s):  

2021 ◽  
Vol 3 (6) ◽  
pp. 01-03
Author(s):  
Z. Pawlak

PLs bilayers coating the major synovial joints such as knees and hips as the lubricant are responsible for the lubrication of articular cartilage. Lamellar-repulsive effect has been considered as a lubrication mechanism but it is likely that lubricin and hyaluronan with PLs participate in the lubrication process. The molecules of lubricin and hyaluronan adsorbed by PLs have a supportive role and provide the efficient lubrication of synovial joints via the hydration mechanism (~ 80% water content). Lipid profiles of injured and healthy knees’ synovial fluids show significant differences. The phospholipid content in synovial fluid (SF) during joint inflammation, osteoarthritis is significantly higher (2 to 3 times) above the normal concentration of PL, and has a poor boundary-lubricating ability because of deactivated PL molecules. Deactivated PL molecule has no ability to form bilayers, lamellar phases, and liposomes.


1996 ◽  
Vol 4 (4) ◽  
pp. 81-94 ◽  
Author(s):  
Susan M. Lord ◽  
Nikolai Bogduk

Sign in / Sign up

Export Citation Format

Share Document