scholarly journals Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab

2008 ◽  
Vol 10 (5) ◽  
pp. R105 ◽  
Author(s):  
Sanna Rosengren ◽  
Nathan Wei ◽  
Kenneth C Kalunian ◽  
Nathan J Zvaifler ◽  
Arthur Kavanaugh ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Synovia ◽  
Lymphoid Aggregates

Synovial T/B Cell Lymphoid Aggregates Regulate the Production of Rheumatoid Arthritis-specific Autoantibodies

2007 ◽  
Vol 123 ◽  
pp. S93
Author(s):  
Tineke Cantaert ◽  
Trieneke Timmer ◽  
Bernard Vandooren ◽  
Carla Wijbrandts ◽  
Rogier Thurlings ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
B Cell ◽  
Lymphoid Aggregates

scholarly journals Pathologic Quantification of Connective Tissue Disease–Associated Versus Idiopathic Usual Interstitial Pneumonia

2012 ◽  
Vol 136 (10) ◽  
pp. 1253-1258 ◽  
Author(s):  
Nicole A. Cipriani ◽  
Mary Strek ◽  
Imre Noth ◽  
Ilyssa O. Gordon ◽  
Jeff Charbeneau ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Connective Tissue ◽  
Interstitial Pneumonia ◽  
Connective Tissue Disease ◽  
Interstitial Pneumonitis ◽  
Interobserver Variability ◽  
Usual Interstitial Pneumonia ◽  
Nonspecific Interstitial Pneumonia ◽  
Salient Features ◽  
Lymphoid Aggregates

Context.—Usual interstitial pneumonia (UIP) is a common chronic interstitial pneumonitis. It can occur idiopathically (I-UIP) or in the setting of systemic connective tissue disease (CTD-UIP). Some studies suggest that CTD-UIP has a better prognosis than I-UIP. The histologic differences between CTD-UIP and I-UIP are not clearly defined. Objective.—The purpose of this study was to evaluate histologic criteria that may differentiate CTD-UIP from I-UIP, including fibroblastic foci (FFs), lymphoid aggregates (LAs), and the presence of nonspecific interstitial pneumonia pattern. Design.—Thirty-five patients with histologic diagnoses of UIP were identified (27 biopsies [77%]; 8 explants [23%]). Biopsy slides were scanned and analyzed quantitatively for FF size, FF area, LA size, and LA area. Biopsy and explant slides were examined qualitatively for the presence of a nonspecific interstitial pneumonia pattern in areas away from UIP fibrosis. Results.—Of 27 biopsies, the number and size of FFs in CTD-UIP were smaller than they were in I-UIP. The number and size of LAs were larger in patients with rheumatoid arthritis than they were in patients with I-UIP. There was no interobserver variability among 3 pathologists using this quantitative system. Of 35 biopsies and explants, there was a higher prevalence of the nonspecific interstitial pneumonia pattern among patients with CTD-UIP than there was among patients with I-UIP (P = .005). Conclusions.—Patients with CTD-UIP had fewer, smaller FFs than did patients with I-UIP, and patients with rheumatoid arthritis-UIP had more, larger LAs than did patients with I-UIP. Of importance, the coexistence of UIP and the nonspecific interstitial pneumonia patterns was one of the most salient features in distinguishing CTD-UIP from I-UIP because CTD-UIP demonstrated an increased prevalence of multilobar, cellular, nonspecific interstitial pneumonia patterns in areas away from the UIP fibrosis.

scholarly journals Increased amount of phosphorylated proinflammatory osteopontin in rheumatoid arthritis synovia is associated to decreased tartrate-resistant acid phosphatase 5B/5A ratio

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0182904 ◽  
Author(s):  
Jani Luukkonen ◽  
Laia Mira Pascual ◽  
Christina Patlaka ◽  
Pernilla Lång ◽  
Sanna Turunen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Acid Phosphatase ◽  
Tartrate Resistant Acid Phosphatase ◽  
Rheumatoid Arthritis Synovia

Association of vitamin D receptor genotypes with early onset rheumatoid arthritis

2001 ◽  
Vol 28 (1) ◽  
pp. 89-93 ◽  
Author(s):  
J. R. Garcia-Lozano ◽  
M. F. Gonzalez-Escribano ◽  
A. Valenzuela ◽  
A. Garcia ◽  
A. Nunez-Roldan
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Early Onset
Sign in / Sign up

Export Citation Format

Share Document