scholarly journals Frequent N Addition and Clonal Relatedness among Immunoglobulin Lambda Light Chains Expressed in Rheumatoid Arthritis Synovia and PBL, and the Influence of Vλ Gene Segment Utilization on CDR3 Length

1998 ◽  
Vol 4 (8) ◽  
pp. 525-553 ◽  
Author(s):  
S. Louis Bridges
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Segment ◽  
Light Chains ◽  
N Addition ◽  
Rheumatoid Arthritis Synovia ◽  
Clonal Relatedness ◽  
Cdr3 Length ◽  
Immunoglobulin Lambda

Are immunoglobulin free light chains levels reliable to assess disease activity in rheumatoid arthritis?

2013 ◽  
Vol 80 (4) ◽  
pp. 437-438 ◽  
Author(s):  
Réda Djidjik ◽  
Nesrine Messaoudani ◽  
Nabil Raaf ◽  
Mohammed Lotfi Boudjella ◽  
Amina Abdessmed ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Light Chains ◽  
Free Light Chains

Mutational Analysis of Immunoglobulin Germline Derived Vλ4B Light Chains in Rheumatoid Arthritis

2001 ◽  
Vol 99 (2) ◽  
pp. 283-290 ◽  
Author(s):  
Thomas P. Kenny ◽  
Thomas J. Semrad ◽  
Wasyl Malyj ◽  
Dick L. Robbins
Keyword(s):  
Rheumatoid Arthritis ◽  
Mutational Analysis ◽  
Light Chains

FRI0335 Serum Levels of Immunoglobulins and Free Light Chains in Patients with Rheumatoid Arthritis Treated with Abatacept

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 508.2-509
Author(s):  
M. Scarsi ◽  
L. Paolini ◽  
D. Ricotta ◽  
E. Colombo ◽  
A. Pedrini ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Levels ◽  
Light Chains ◽  
Free Light Chains

scholarly journals Elevated autoantibody content in rheumatoid arthritis synovia with lymphoid aggregates and the effect of rituximab

2008 ◽  
Vol 10 (5) ◽  
pp. R105 ◽  
Author(s):  
Sanna Rosengren ◽  
Nathan Wei ◽  
Kenneth C Kalunian ◽  
Nathan J Zvaifler ◽  
Arthur Kavanaugh ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Synovia ◽  
Lymphoid Aggregates

Mutational Analysis of Immunoglobulin Germline Derived Vλ4A Light Chains in Rheumatoid Arthritis

2001 ◽  
Vol 99 (2) ◽  
pp. 276-282 ◽  
Author(s):  
Thomas J. Semrad ◽  
Thomas P. Kenny ◽  
Wasyl Malyj ◽  
Dick L. Robbins
Keyword(s):  
Rheumatoid Arthritis ◽  
Mutational Analysis ◽  
Light Chains

scholarly journals A new variable region in mouse immunoglobulin lambda light chains.

1987 ◽  
Vol 166 (1) ◽  
pp. 265-270 ◽  
Author(s):  
P Sanchez ◽  
P A Cazenave
Keyword(s):  
Light Chain ◽  
Single Injection ◽  
Gene Segment ◽  
Variable Region ◽  
Light Chains ◽  
Lambda Light Chain ◽  
Segment Sequence ◽  
Cell Clones ◽  
Mouse Immunoglobulin ◽  
Lambda Probe

A series of lambda+ murine hybridomas were derived from a BALB/c mouse after a single injection of anti-lambda 2 antibodies coupled to LPS. Nine lambda B cell clones (five lambda 2 and four lambda 3) were expected and seven reacted with antibodies specific for the C lambda 2 constant region but showed a particular isoelectric spectrum. Their RNA products did not hybridize with the V lambda probe. The partial DNA sequence of gene segments coding the unexpected light chain of one hybridoma shows that the V gene segment has only 55% homology with the V lambda 2 gene segment sequence and that J lambda 2 and probably C lambda 2 gene segments are used. Taken together, these results demonstrate the existence of a new lambda light chain.

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