scholarly journals Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

2008 ◽  
Vol 10 (2) ◽  
pp. R32 ◽  
Author(s):  
Koert M Dolman ◽  
Nannette Brouwer ◽  
Florine NJ Frakking ◽  
Berit Flato ◽  
Paul P Tak ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Juvenile Rheumatoid Arthritis ◽  
Early Onset ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study

2021 ◽  
pp. 107873
Author(s):  
Anne Gedebjerg ◽  
Reimar Wernich Thomsen ◽  
Alisa Devedzic Kjaergaard ◽  
Rudi Steffensen ◽  
Jens Steen Nielsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Danish Cohort ◽  
Binding Lectin

scholarly journals Mannose-binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study

2020 ◽  
Author(s):  
Anne Gedebjerg ◽  
Mette Bjerre ◽  
Alisa Devedzic Kjaergaard ◽  
Rudi Steffensen ◽  
Jens Steen Nielsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Cardiovascular Events ◽  
Cox Regression ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
All Cause Mortality ◽  
Binding Lectin

<b>Objective</b>: Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease in diabetes, but the nature of the association is unclear. We investigated the association between MBL and risk of cardiovascular events (CVE) and all-cause mortality in type 2 diabetes. <p><b>Research Design and Methods</b>: In a cohort study of 7588 patients with type 2 diabetes, we measured serum MBL in 7305 and performed MBL expression genotyping in 3043. We grouped serum MBL and MBL expression genotypes into three categories: low, intermediate, and high. Outcomes were CVE (myocardial infarction, stroke, coronary revascularization, unstable angina, and cardiovascular death) and all-cause mortality. The association with outcomes was examined by spline and Cox regression analyses. </p> <p><b>Results</b>: Serum MBL and CVE showed a U-shaped association. Compared to the intermediate serum MBL category, the adjusted hazard ratio (HR) for CVE was 1.82 (95% CI, 1.34 to 2.46) for the low-MBL category and 1.48 (95% CI, 1.14 to 1.92) for the high-MBL category. We found a similar U-shaped association for all-cause mortality, but with lower risk estimates. Compared to the intermediate MBL expression genotype, the adjusted HR for CVE was 1.40 (95% CI, 0.87 to 2.25) for the low-expression genotype and 1.44 (95% CI, 1.01 to 2.06) for the high-expression genotype. MBL expression genotype was not associated with all-cause mortality. </p> <p><b>Conclusions:</b> Both serum MBL and MBL expression genotype showed a U-shaped association with CVE risk in individuals with type 2 diabetes. Our findings suggest that serum MBL is a risk factor for cardiovascular disease in this population.</p>

scholarly journals Mannose-binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study

2020 ◽  
Author(s):  
Anne Gedebjerg ◽  
Mette Bjerre ◽  
Alisa Devedzic Kjaergaard ◽  
Rudi Steffensen ◽  
Jens Steen Nielsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cohort Study ◽  
Cardiovascular Events ◽  
Cox Regression ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
All Cause Mortality ◽  
Binding Lectin

<b>Objective</b>: Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease in diabetes, but the nature of the association is unclear. We investigated the association between MBL and risk of cardiovascular events (CVE) and all-cause mortality in type 2 diabetes. <p><b>Research Design and Methods</b>: In a cohort study of 7588 patients with type 2 diabetes, we measured serum MBL in 7305 and performed MBL expression genotyping in 3043. We grouped serum MBL and MBL expression genotypes into three categories: low, intermediate, and high. Outcomes were CVE (myocardial infarction, stroke, coronary revascularization, unstable angina, and cardiovascular death) and all-cause mortality. The association with outcomes was examined by spline and Cox regression analyses. </p> <p><b>Results</b>: Serum MBL and CVE showed a U-shaped association. Compared to the intermediate serum MBL category, the adjusted hazard ratio (HR) for CVE was 1.82 (95% CI, 1.34 to 2.46) for the low-MBL category and 1.48 (95% CI, 1.14 to 1.92) for the high-MBL category. We found a similar U-shaped association for all-cause mortality, but with lower risk estimates. Compared to the intermediate MBL expression genotype, the adjusted HR for CVE was 1.40 (95% CI, 0.87 to 2.25) for the low-expression genotype and 1.44 (95% CI, 1.01 to 2.06) for the high-expression genotype. MBL expression genotype was not associated with all-cause mortality. </p> <p><b>Conclusions:</b> Both serum MBL and MBL expression genotype showed a U-shaped association with CVE risk in individuals with type 2 diabetes. Our findings suggest that serum MBL is a risk factor for cardiovascular disease in this population.</p>

scholarly journals Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis

Rheumatology ◽  
1998 ◽  
Vol 37 (2) ◽  
pp. 186-188 ◽  
Author(s):  
S. J. Stanworth ◽  
R. P. Donn ◽  
A. Hassall ◽  
P. Dawes ◽  
W. Ollier ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Can mannose-binding lectin explain the course and outcome of pregnancy in rheumatoid arthritis?

2010 ◽  
Vol 69 (Suppl 2) ◽  
pp. A42-A43
Author(s):  
F. E. van de Geijn ◽  
Y. A. de Man ◽  
M. Wuhrer ◽  
S. P. Willemsen ◽  
A. M. Deelder ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin deficiency and miscarriages in rheumatoid arthritis

Autoimmunity ◽  
2017 ◽  
Vol 50 (7) ◽  
pp. 409-413 ◽  
Author(s):  
Juliana Z. Cieslinski ◽  
Isabela Goeldner ◽  
Thelma l. Skare ◽  
Renato Nisihara ◽  
Fabiana A. De Andrade ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

Double role of mannose-binding lectin in relation to carotid intima–media thickness in patients with rheumatoid arthritis

2010 ◽  
Vol 47 (4) ◽  
pp. 713-718 ◽  
Author(s):  
Lone N. Troelsen ◽  
Peter Garred ◽  
Buris Christiansen ◽  
Christian Torp-Pedersen ◽  
Ib J. Christensen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mannose Binding Lectin ◽  
Media Thickness ◽  
Mannose Binding ◽  
Binding Lectin
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