S-Nitrosylation of mannose binding lectin regulates its functional activities and the formation of autoantibody in rheumatoid arthritis

Nitric Oxide ◽  
2008 ◽  
Vol 18 (4) ◽  
pp. 266-273 ◽  
Author(s):  
Bhawna Gupta ◽  
Sunil K. Raghav ◽  
Hasi R. Das
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Functional Activities ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Absence of an association between mannose-binding lectin polymorphism and rheumatoid arthritis

Rheumatology ◽  
1998 ◽  
Vol 37 (2) ◽  
pp. 186-188 ◽  
Author(s):  
S. J. Stanworth ◽  
R. P. Donn ◽  
A. Hassall ◽  
P. Dawes ◽  
W. Ollier ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose-binding lectin deficiency is associated with early onset of polyarticular juvenile rheumatoid arthritis: a cohort study

2008 ◽  
Vol 10 (2) ◽  
pp. R32 ◽  
Author(s):  
Koert M Dolman ◽  
Nannette Brouwer ◽  
Florine NJ Frakking ◽  
Berit Flato ◽  
Paul P Tak ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cohort Study ◽  
Juvenile Rheumatoid Arthritis ◽  
Early Onset ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Can mannose-binding lectin explain the course and outcome of pregnancy in rheumatoid arthritis?

2010 ◽  
Vol 69 (Suppl 2) ◽  
pp. A42-A43
Author(s):  
F. E. van de Geijn ◽  
Y. A. de Man ◽  
M. Wuhrer ◽  
S. P. Willemsen ◽  
A. M. Deelder ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin deficiency and miscarriages in rheumatoid arthritis

Autoimmunity ◽  
2017 ◽  
Vol 50 (7) ◽  
pp. 409-413 ◽  
Author(s):  
Juliana Z. Cieslinski ◽  
Isabela Goeldner ◽  
Thelma l. Skare ◽  
Renato Nisihara ◽  
Fabiana A. De Andrade ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

Double role of mannose-binding lectin in relation to carotid intima–media thickness in patients with rheumatoid arthritis

2010 ◽  
Vol 47 (4) ◽  
pp. 713-718 ◽  
Author(s):  
Lone N. Troelsen ◽  
Peter Garred ◽  
Buris Christiansen ◽  
Christian Torp-Pedersen ◽  
Ib J. Christensen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mannose Binding Lectin ◽  
Media Thickness ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Undetectable Mannose Binding Lectin and Corticosteroids Increase Serious Infection Risk in Rheumatoid Arthritis

2017 ◽  
Vol 5 (6) ◽  
pp. 1609-1616 ◽  
Author(s):  
Graeme J. Carroll ◽  
Krista Makin ◽  
Maxine Garnsey ◽  
Max Bulsara ◽  
Bronwyn V. Carroll ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Infection Risk ◽  
Mannose Binding Lectin ◽  
Serious Infection ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Variant mannose-binding lectin genotypes and outcome in early versus late rheumatoid arthritis: Comment on the article by Ip et al

2002 ◽  
Vol 46 (2) ◽  
pp. 555-556 ◽  
Author(s):  
Niels A. Graudal ◽  
Peter Garred ◽  
Hans O. Madsen ◽  
Arne Svejgaard ◽  
Ulrik Tarp ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mortality and Predictors of Mortality in Rheumatoid Arthritis — A Role for Mannose-binding Lectin?

2010 ◽  
Vol 37 (3) ◽  
pp. 536-543 ◽  
Author(s):  
LONE N. TROELSEN ◽  
PETER GARRED ◽  
SØREN JACOBSEN
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Mortality ◽  
Cardiovascular Death ◽  
Mannose Binding Lectin ◽  
Nutritional State ◽  
Standardized Mortality Ratio ◽  
Risk Of Death ◽  
Increased Risk ◽  
Mannose Binding ◽  
Binding Lectin

Objective.Patients with rheumatoid arthritis (RA) have increased overall and cardiovascular mortality. Mannose-binding lectin (MBL) may play differentiated roles in the pathogenesis of RA. We had observed that high serum levels of MBL increased the risk of ischemic heart disease in patients with RA. In this followup study we describe the mortality in a cohort of 229 Danish patients with RA. We examine if previously reported factors and MBL influence the risk of overall death and death due to cardiovascular disease.Methods.Known predictors of RA mortality were assessed. MBL extended genotypes (YA/YA, YA/XA, XA/XA, YA/YO, XA/YO, YO/YO) were determined; MBL serum concentrations were measured. The vital status and causes of death were assessed in a prospective study.Results.The median followup was 10.3 years. The overall risk of death was 4% per year. Comparing mortality in the RA cohort with mortality in an age- and sex-matched cohort based on the general Danish population, we found significantly increased overall mortality [standardized mortality ratio (SMR) 1.5, 95% CI 1.2–1.9, and cardiovascular mortality (SMR 1.7, 95% CI 1.3–2.6)]. In multivariate analysis, significant predictors of overall death were extraarticular manifestations, positive rheumatoid factor, increased C-reactive protein (CRP), poor nutritional state, and serum MBL. Predictors of cardiovascular death were Health Assessment Questionnaire score, increased CRP, poor nutritional state, and the high-producing MBL genotype YA/YA.Conclusion.Both overall and cardiovascular mortality were increased in Danish patients with RA. In our cohort, states of high MBL production and several previously reported factors contributed significantly to this increased risk of overall death and cardiovascular death.

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