scholarly journals Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes

2008 ◽  
Vol 10 (1) ◽  
pp. R7 ◽  
Author(s):  
R Andrew Moore ◽  
Sheena Derry ◽  
Henry J McQuay
Keyword(s):  
Systematic Review ◽  
Blood Loss ◽  
Randomized Trials ◽  
Selective Inhibitors ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Faecal Blood Loss

Gastro-Intestinal Blood Loss during Administration of Indoprofen, Aspirin and Ibuprofen

1977 ◽  
Vol 5 (3) ◽  
pp. 155-160 ◽  
Author(s):  
G Bianchi Porro ◽  
G Corvi ◽  
L M Fuccella ◽  
G C Goldaniga ◽  
G Valzelli
Keyword(s):  
Blood Loss ◽  
Acetylsalicylic Acid ◽  
Fold Increase ◽  
Acute Effect ◽  
Gastrointestinal Mucosa ◽  
Order Of Magnitude ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Faecal Blood Loss

The acute effect of three non-steroidal anti-inflammatory drugs, ibuprofen, acetylsalicylic acid (ASA) and indoprofen, on faecal blood loss was investigated in 15 subjects by means of 51Cr-labelled erythrocytes. Ibuprofen (900 mg/day for 5 days) and indoprofen capsules and tablets (300 mg and 600 mg/day for 5 days, respectively) slightly increased the amount of blood eliminated in faeces. The increase was of the same order of magnitude for both doses of indoprofen. ASA (1,500 mg/day for 5 days) caused about a 6-fold increase in blood loss. Four days after withdrawal of ASA, faecal blood was still about twice as high as in faeces of subjects given ibuprofen and indoprofen. The method appears sensitive and reliable for comparison of the immediate effect of anti-inflammatory drugs on gastrointestinal mucosa.

scholarly journals Hyaluronic Acid Injections or Oral Nonsteroidal Anti-inflammatory Drugs for Knee Osteoarthritis: Systematic Review and Meta-analysis of Randomized Trials

2020 ◽  
Vol 8 (1) ◽  
pp. 232596711989790 ◽  
Author(s):  
Larry E. Miller ◽  
Michael Fredericson ◽  
Roy D. Altman
Keyword(s):  
Systematic Review ◽  
Hyaluronic Acid ◽  
Knee Osteoarthritis ◽  
Knee Pain ◽  
Randomized Trials ◽  
Knee Function ◽  
Knee Oa ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Intra-articular hyaluronic acid (HA) injections and oral nonsteroidal anti-inflammatory drugs (NSAIDs) are common treatments for symptomatic knee osteoarthritis (OA). However, the comparative effects of these treatments are unclear. Purpose: To compare the efficacy and safety of intra-articular HA injections compared with oral NSAIDs for the treatment of knee OA. Study Design: Systematic review; Level of evidence, 1. Methods: We systematically searched Medline, Embase, and the Cochrane Central Register of Controlled Trials for randomized trials of knee OA treatment with HA injections compared with oral NSAIDs. The main outcomes were knee pain, knee function, adverse events (AEs), serious AEs, study withdrawals, and study withdrawals because of AEs. Pooled effect sizes were reported at the final follow-up with standardized mean difference (SMD) for efficacy outcomes and risk ratio (RR) for safety outcomes. Results: In 6 randomized trials of 831 patients (414 HA, 417 NSAIDs), with follow-up ranging from 5 to 26 weeks, HA injections were associated with small, statistically significant improvements in knee pain (SMD, 0.15; P = .04) and knee function (SMD, 0.23; P = .01) compared with oral NSAIDs. The risk of AEs was lower with HA compared with NSAIDs (19.8% vs 29.0%; RR, 0.74; P = .01). The risk of a serious AE (RR, 1.37; P = .71), study withdrawal (RR, 1.05; P = .68), or study withdrawal because of an AE (RR, 0.65; P = .22) was comparable between groups. Gastrointestinal concerns were the most frequent AE reported, occurring more often with NSAIDs (23.4% vs 14.1%; P = .001). AEs reported more frequently with HA injections were injection site pain (11.7% vs 4.7%; P < .001), headache (8.4% vs 4.4%; P = .03), and arthralgia (8.1% vs 2.9%; P = .001). Significant heterogeneity or publication bias was not observed for any outcome. Conclusion: Comparing short-term outcomes of HA injections with oral NSAIDs for treatment of knee OA, HA injections provided statistically significant but not clinically important improvements in knee pain and function, along with a lower overall risk of AEs.

scholarly journals Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis

Rheumatology ◽  
2014 ◽  
Vol 54 (4) ◽  
pp. 736-742 ◽  
Author(s):  
Patompong Ungprasert ◽  
Narat Srivali ◽  
Karn Wijarnpreecha ◽  
Prangthip Charoenpong ◽  
Eric L. Knight
Keyword(s):  
Systematic Review ◽  
Venous Thromboembolism ◽  
Meta Analysis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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