Retrospective study of the association between transfusion frequency and potential complications of iron overload in patients with myelodysplastic syndrome and other acquired hematopoietic disorders

2008 ◽  
Vol 25 (1) ◽  
pp. 139-147 ◽  
Author(s):  
Thomas E. Delea ◽  
May Hagiwara ◽  
Pradyumna D. Phatak
Keyword(s):  
Retrospective Study ◽  
Myelodysplastic Syndrome ◽  
Iron Overload ◽  
Hematopoietic Disorders

scholarly journals EnvIRONmental Aspects in Myelodysplastic Syndrome

2021 ◽  
Vol 22 (10) ◽  
pp. 5202
Author(s):  
Verena Petzer ◽  
Igor Theurl ◽  
Günter Weiss ◽  
Dominik Wolf
Keyword(s):  
Myelodysplastic Syndrome ◽  
Iron Overload ◽  
Iron Homeostasis ◽  
Clonal Evolution ◽  
Red Blood Cell Transfusion ◽  
Bone Marrow Niche ◽  
Environmental Aspects ◽  
Complete Understanding ◽  
Mediated Effects ◽  
Important Player

Systemic iron overload is multifactorial in patients suffering from myelodysplastic syndrome (MDS). Disease-immanent ineffective erythropoiesis together with chronic red blood cell transfusion represent the main underlying reasons. However, like the genetic heterogeneity of MDS, iron homeostasis is also diverse in different MDS subtypes and can no longer be generalized. While a certain amount of iron and reactive oxygen species (ROS) are indispensable for proper hematological output, both are harmful if present in excess. Consequently, iron overload has been increasingly recognized as an important player in MDS, which is worth paying attention to. This review focuses on iron- and ROS-mediated effects in the bone marrow niche, their implications for hematopoiesis and their yet unclear involvement in clonal evolution. Moreover, we provide recent insights into hepcidin regulation in MDS and its interaction between erythropoiesis and inflammation. Based on Tet methylcytosine dioxygenase 2 (TET2), representing one of the most frequently mutated genes in MDS, leading to disturbances in both iron homeostasis and hematopoiesis, we highlight that different genetic alteration may have different implications and that a comprehensive workup is needed for a complete understanding and development of future therapies.

DI-002 Effectiveness and safety of deferasirox in the treatment of transfusional iron overload in myelodysplastic syndrome in clinical practice

2016 ◽  
Vol 23 (Suppl 1) ◽  
pp. A119.1-A119
Author(s):  
V Escudero-Vilaplana ◽  
O Mejias-Gomez ◽  
J Leal de La Encina ◽  
X Gonzalez-Garcia ◽  
S Osorio-Prendes ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Myelodysplastic Syndrome ◽  
Iron Overload

210 DECITABINE TREATMENT COULD AMELIORATE PRIMARY IRON-OVERLOAD IN MYELODYSPLASTIC SYNDROME PATIENTS

2015 ◽  
Vol 39 ◽  
pp. S105
Author(s):  
C. Chunkang ◽  
S. Gu ◽  
Y. Zhao ◽  
J. Guo ◽  
C. Fei ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Iron Overload

scholarly journals The impact of chelation therapy on survival in transfusional iron overload: a meta-analysis of myelodysplastic syndrome

2014 ◽  
Vol 167 (5) ◽  
pp. 720-723 ◽  
Author(s):  
Arch G. Mainous ◽  
Rebecca J. Tanner ◽  
Mary M. Hulihan ◽  
Mirna Amaya ◽  
Thomas D. Coates
Keyword(s):  
Myelodysplastic Syndrome ◽  
Iron Overload ◽  
Chelation Therapy ◽  
Meta Analysis ◽  
The Impact

P-113 The efficacy and tolerabilityof ICL670, a once-daily oral iron chelator, in patients with myelodysplastic syndrome (MDS) and iron overload

2005 ◽  
Vol 29 ◽  
pp. S67 ◽  
Author(s):  
N. Gattermann ◽  
M. Cazzola ◽  
P. Greenberg ◽  
J. Maertens ◽  
D. Soulieres ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Iron Overload ◽  
Iron Chelator ◽  
Oral Iron ◽  
Once Daily ◽  
Oral Iron Chelator

Copper and Iron Status in Myelodysplastic Syndromes.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 4593-4593
Author(s):  
Zoi Saouli ◽  
Zisis Kontoninas ◽  
Fotios Girtovitis ◽  
Georgia Kaiafa ◽  
George Ntaios ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Iron Overload ◽  
Copper Deficiency ◽  
Iron Status ◽  
Mean Value ◽  
Normal Range ◽  
Flame Atomic Absorption ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Introduction: Copper is an essential mineral found in many tissues. It is involved in iron incorporation into hemoglobin, hemolytic syndromes, while copper deficiency provokes iron overload and induces dysplastic changes to erythrocytes. On the other hand, there are references that iron overload can result in mild copper deficiency. There seems to be equivocal relationship between these two elements. Aim: The aim of this study is to determine copper and iron status in myelodysplastic patients and to investigate if copper deficiency correlates with the type of myelodysplastic syndrome. Materials and methods: We studied 52 patients with myelodysplastic syndrome, 29 men and 23 women(mean age 67,05± years). No other simultaneous disease was confirmed which could contribute to copper disorders. Patients were categorized in two groups. Group A, composed of 21 patients frequently transfused(approximately once monthly), suffering from RAEB, RAEB-t AND CMML. Group B included 31 patients, who either didn’t often need transfusion, or responded to erythropoietin, suffering from RA and RARS. Copper, iron and ferritin levels measurments were performed. Copper was measured by flame atomic absorption spectrometry (normal range: 0,8–1,3mg/l). Results: Nine patients of group A revealed copper deficiency(mean value 0,66±0,06mg/L). Mean copper value was 0,8±0,11mg/L for that group. All of them had elevated iron levels (average:602,23±160,46μg/dl) and high ferritin levels(average:1769±693,85ng/ml) All group B patients were found to have normal copper levels(Mean value was 1,15±0,09), indicating a statistically significant difference compared to group A patients(p<0,0001). Iron and ferritin levels were within normal range(average105,22±28,63 and 82,9±28,42 respectively) Conclusions: Copper levels, in multitransfused patients with poor prognosis myelodysplastic syndrome and iron overload, are significantly lower than in oligotransfused ones with good prognosis who consequently present normal iron burden.

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