scholarly journals Host transcriptomics for diagnosis of infectious diseases: one step closer to clinical application

2017 ◽  
Vol 49 (6) ◽  
pp. 1700993 ◽  
Author(s):  
Octavio Ramilo ◽  
Asuncion Mejias
Keyword(s):  
Infectious Diseases ◽  
Clinical Application ◽  
One Step

scholarly journals Self etch adhesives - An update

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 464-468
Author(s):  
Nishanthana Murali ◽  
Balaji Ganesh S ◽  
Anitha Roy
Keyword(s):  
Clinical Application ◽  
Mixed Layer ◽  
Bonding Agent ◽  
Advantages And Disadvantages ◽  
Acid Type ◽  
Etch And Rinse ◽  
Dental Hard Tissues ◽  
Hard Tissues ◽  
One Step ◽  
Self Etch

Self etch adhesives are one of the most recent advancements the field of dentistry has seen recently. Adhesive frameworks today are either an "etch and rinse or total etch" or "self-etch" approach, which contrast by the way they interact with the tooth structures. Total etch frameworks include phosphoric etchants to pretreat the dental hard tissues before the ensuing use of a bonding agent. Self-etch type of adhesives are generally consisting of acid type monomers, that perform the actions of etching and rinsing the tooth structures at the same time. The former type of total etch adhesives are consistent with step frameworks, contingent upon the primer and bonding agent being independent or joined in a solitary container. Thus, self etch systems seem to be easily accessible as they are a couple of phase framework. Both the framework systems structure a mixed layer because the resin is infiltrating the permeable dentin or enamel. In spite of current patterns leaning in the direction of less straightforward clinical application steps, one-step holding frameworks seem to have lower bonding qualities and appear to be less foreseeable than multi-step etch and rinse, or self etch systems. They have a variety of advantages and disadvantages which are discussed in this article. They are more popular nowadays, and this review also includes its advantages over the etch and rinse system and as well as its disadvantages compared to the etch and rinse system. It also includes the types of self etch adhesives based on the steps and range of acidity as well as some of its properties.

scholarly journals Clinical application of cell-free next-generation sequencing for infectious diseases at a tertiary children’s hospital

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Julianne Wilke ◽  
Nanda Ramchandar ◽  
Christopher Cannavino ◽  
Alice Pong ◽  
Adriana Tremoulet ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Infectious Diseases ◽  
Clinical Application ◽  
Clinical Care ◽  
Next Generation ◽  
Children's Hospital ◽  
Percent Agreement ◽  
Children’S Hospital ◽  
The Impact ◽  
Generation Sequencing

Abstract Background Children affected by infectious diseases may not always have a detectable infectious etiology. Diagnostic uncertainty can lead to prolonged hospitalizations, inappropriately broad or extended courses of antibiotics, invasive diagnostic procedures, and difficulty predicting the clinical course and outcome. Cell-free plasma next-generation sequencing (cfNGS) can identify viral, bacterial, and fungal infections by detecting pathogen DNA in peripheral blood. This testing modality offers the ability to test for many organisms at once in a shotgun metagenomic approach with a rapid turnaround time. We sought to compare the results of cfNGS to conventional diagnostic test results and describe the impact of cfNGS on clinical care in a diverse pediatric population at a large academic children’s hospital. Methods We performed a retrospective chart review of hospitalized subjects at a tertiary pediatric hospital to determine the diagnostic yield of cfNGS and its impact on clinical care. Results We describe the clinical application of results from 142 cfNGS tests in the management of 110 subjects over an 8-month study period. In comparison to conventional testing as a reference standard, cfNGS was found to have a positive percent agreement of 89.6% and negative percent agreement of 52.3%. Furthermore, 32.4% of cfNGS results were directly applied to make a clinical change in management. Conclusions We demonstrate the clinically utility of cfNGS in the management of acutely ill children. Future studies, both retrospective and prospective, are needed to clarify the optimal indications for testing.

One step closer to precision medicine for infectious diseases

2019 ◽  
Vol 19 (6) ◽  
pp. 564-565 ◽  
Author(s):  
Mathias W Pletz ◽  
Michael Bauer ◽  
Axel A Brakhage
Keyword(s):  
Infectious Diseases ◽  
Precision Medicine ◽  
One Step

scholarly journals Fundamental Studies on Talampicillin Hydrochloride and Clinical Application to Respiratory Infectious Diseases

1975 ◽  
Vol 49 (11) ◽  
pp. 534-541
Author(s):  
Masaru NASU ◽  
Atsushi SAITO ◽  
Masaaki IWANAGA ◽  
Tsuneo TSUTSUMI ◽  
Masatake HIROTA ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Clinical Application ◽  
Respiratory Infectious Diseases

scholarly journals The Clinical Application Value of Cytokines in Treating Infectious Diseases

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98745 ◽  
Author(s):  
Qing Ye ◽  
Wen-Xia Shao ◽  
Xiao-Jun Xu ◽  
Ying-zhi Yang
Keyword(s):  
Infectious Diseases ◽  
Clinical Application
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