AGE TREND IN HEPATITIS C VIRUS GENOTYPE DISTRIBUTION AS SEEN IN A BRUSSELS TEACHING HOSPITAL

2001 ◽  
Vol 56 (4) ◽  
pp. 220-224 ◽  
Author(s):  
A.-I. de Moreau de Gerbehaye ◽  
M. Bodéus ◽  
P. Goubau
2020 ◽  
Vol 31 (2) ◽  
pp. 128-135
Author(s):  
Alev Cetin Duran ◽  
◽  
Ozgul Kaya Cetinkaya ◽  
Ayca Arzu Sayiner ◽  
Gulsah Seydaoglu ◽  
...  

2015 ◽  
Vol 7 (6) ◽  
pp. 102-107
Author(s):  
Tyczyno Ma gorzata ◽  
Pniewska Anna ◽  
Halota Waldemar ◽  
Paw owska Ma gorzata ◽  
Wietlicka Piszcz Magdalena

2016 ◽  
Vol 54 (7) ◽  
pp. 1855-1861 ◽  
Author(s):  
Melanie R. Walker ◽  
Hui Li ◽  
Suzy Teutsch ◽  
Brigid Betz-Stablein ◽  
Fabio Luciani ◽  
...  

Hepatitis C virus (HCV) is a highly diverse pathogen that is classified into seven distinct genotypes. Simultaneous or sequential reinfection with multiple HCV genotypes is recognized in high-risk populations, such as injecting drug users (IDUs). Multiple infection is of clinical concern as different genotypes have various sensitivities to current antiviral therapies. Therefore, a better understanding of the frequency of multiple infection and of the genotypes currently being transmitted is clinically relevant. An Australian cohort of IDUs (n= 123), identified with primary incident infection, was followed for multiple infection by regular HCV RNA testing between 2005 and 2013. A total of 354 samples were tested. Sequencing of primary incident infections revealed that genotype 3a was the most common circulating genotype, followed by genotype 1a. Examination of longitudinally collected samples identified complex patterns of multiple infection, including reinfection and superinfection. In those with multiple infection, there was no apparent evidence of homotypic immunity conferring protection against reinfection of the same subtype. This study revealed frequent multiple infection in a high-risk prisoner cohort, illustrating the complex nature of HCV infection and reinfection and highlighting the need for pan-genotypic antiviral therapies.


2013 ◽  
Vol 14 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Omayma Saleh ◽  
Azza A. Baiomy ◽  
Ayman El-desouky ◽  
Hosam Zaghloul ◽  
Mohammad El-Arman ◽  
...  

2016 ◽  
Vol 10 (2) ◽  
pp. 138
Author(s):  
Reza Hatami-Moghadam ◽  
Reza Alibakhshi ◽  
Babak Sayyad

<p><span style="font-size: 10.5pt; font-family: 'Times New Roman','serif'; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0pt; mso-ansi-language: EN-US; mso-fareast-language: ZH-CN; mso-bidi-language: AR-SA; mso-bidi-font-size: 12.0pt;" lang="EN-US">Six major hepatitis C virus genotypes have been characterized, which vary in their geographical distribution. Knowledge of the distribution of various genotypes is essential for successful future research, treatment and control strategies. In this study, the distribution of HCV genotypes and their association with possible risk factors in a group of HCV infected patients from Kermanshah province of Iran was investigated. HCV viral load test by Real time- PCR method was used for diagnosis of infected cases. The genotypes of cases were revealed using Nested- and Multiplex-PCR and with direct sequencing results were confirmed. Risk factors were also recorded and a multivariate analysis was performed. Among 180 infected people, 138 (76.6%) with 3a genotype, 35 (19.4%) with 1a genotype, 3 (1.7%) with 1b genotype and 4 (2.2%) with 3a and 1b were determined. HCV was transmitted by different routes such as intravenous drug abuse (IVDA), tattooing, sexual, blood transfusion and other risk factors. IVDA and sex are the main risk factors in the men and women, respectively. However, 3a is the predominant genotype in the all groups. This study revealed that 3a is the most prevalent genotypes in Kermanshah province.</span></p>


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