scholarly journals Chromogranins A and B are co-localized with atrial natriuretic peptides in secretory granules of rat heart.

1990 ◽  
Vol 38 (6) ◽  
pp. 845-850 ◽  
Author(s):  
H J Steiner ◽  
R Weiler ◽  
C Ludescher ◽  
K W Schmid ◽  
H Winkler
Keyword(s):  
Natriuretic Peptides ◽  
Rat Heart ◽  
Secretory Granules ◽  
Atrial Natriuretic Peptides ◽  
Atrial Natriuretic

scholarly journals An immunocytochemical study on co-localization of cathepsin B and atrial natriuretic peptides in secretory granules of atrial myoendocrine cells of rat heart.

1989 ◽  
Vol 37 (3) ◽  
pp. 347-351 ◽  
Author(s):  
T Watanabe ◽  
M Watanabe ◽  
Y Ishii ◽  
H Matsuba ◽  
S Kimura ◽  
...  
Keyword(s):  
Natriuretic Peptides ◽  
Cathepsin B ◽  
Rat Heart ◽  
Secretory Granules ◽  
Atrial Natriuretic Peptides ◽  
Thin Sections ◽  
Gold Particles ◽  
Atrial Tissue ◽  
Myoendocrine Cells ◽  
Atrial Natriuretic

To examine localization of cathepsin B, a representative lysosomal cysteine protease, in atrial myoendocrine cells of the rat heart, immunohistochemistry at the light and electron microscopic level was applied to the atrial tissue, using a monospecific antibody for rat liver cathepsin B. In serial semi-thin sections, immunoreactivity for cathepsin B and atrial natriuretic peptides (ANP) was detected in the para-nuclear region of atrial myoendocrine cells. Several large granules and many fine granules in the region of the cells were positively stained by the cathepsin B antibody. Gold particles indicating cathepsin B antigenicity labeled secretory granules in the cells, which were also labeled by those indicating ANP, using thin sections of the Lowicryl K4M-embedded material. Moreover, some granules labeled densely by immunogold particles for cathepsin B seemed to be lysosomes. By double immunostaining using thin sections of the Epon-embedded material, gold particles indicating cathepsin B and ANP antigenicities were co-localized in secretory granules of the cells. By enzyme assay, activity of cathepsin B was three times higher in atrial tissue than ventricular tissue. The results suggest that co-localization of cathepsin B and ANP in secretory granules is compatible with the possibility that cathepsin B participates in the maturation process of ANP.

Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans

Metabolism ◽  
1996 ◽  
Vol 45 (3) ◽  
pp. 315-319 ◽  
Author(s):  
David L. Vesely ◽  
Shirley Chiou ◽  
Margaret A. Douglass ◽  
Michael T. McCormick ◽  
George Rodriguez-Paz ◽  
...  
Keyword(s):  
Natriuretic Peptides ◽  
Atrial Natriuretic Peptides ◽  
Atrial Natriuretic

Structure-Activity Relationships of Atrial Natriuretic Peptides

1987 ◽  
pp. 77-82 ◽  
Author(s):  
Gaétan Thibault ◽  
Raul Garcia ◽  
Ernesto L. Schiffrin ◽  
Andre De Léan ◽  
Peter W. Schiller ◽  
...  
Keyword(s):  
Natriuretic Peptides ◽  
Atrial Natriuretic Peptides ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Atrial Natriuretic
Sign in / Sign up

Export Citation Format

Share Document