scholarly journals Immunocytochemical studies of relaxin in ovaries of pregnant and cycling mice.

1985 ◽  
Vol 33 (4) ◽  
pp. 303-308 ◽  
Author(s):  
M R Vaupel ◽  
O D Sherwood ◽  
M B Anderson
Keyword(s):  
New York ◽  
Pregnant Mouse ◽  
The Other ◽  
Immunocytochemical Staining ◽  
Corpora Lutea ◽  
Serial Sections ◽  
Pregnant Mice ◽  
Implantation Sites ◽  
Immunocytochemical Studies ◽  
The Right

Immunocytochemical staining for relaxin in ovarian sections of pregnant mice from day 11 through day 18 of gestation revealed that only corpora lutea (CL) of pregnancy are stained. Evaluation of serial sections of ovaries from a day 16 pregnant mouse revealed that the only luteal structures present are CL of pregnancy. The number of CL present in each ovary equaled the number of implantation sites in each related horn (7 on the right side and 8 on the left side). These large CL varied in shape, being round in some profiles to very elongate in others. All CL were immunochemically stained for relaxin using the peroxidase-antiperoxidase method of L. Sternberger (Immunocytochemistry, 2nd ed. Wiley, New York, 1979). The intensity of the strain varied from cell to cell within each CL. Small luteal structures that were observed to be immunochemically stained for relaxin were demonstrated to represent the periphery of CL of pregnancy. No luteinized follicles were observed and interstitial cells and follicles were not immunochemically stained in any of the day 16 serial ovarian sections or in any of the ovarian sections from pregnant mice on the other days of gestation studied. CL of previous cycles were not observed to be present in the ovaries at days 15, 16, or 18 of gestation. However on day 14 and before, CL of previous cycles were observed and they did not exhibit any relaxin immunostaining. Immunocytochemical studies using the biotin-avidin system revealed that no relaxin immunostaining could be demonstrated in the ovaries of cycling mice at any stage of the estrous cycle. In conclusion, this study revealed that the only ovarian structures demonstrating relaxin immunocytochemical staining in the mouse were CL of pregnancy.

scholarly journals Studies on Amphibian Metamorphosis

1939 ◽  
Vol 16 (1) ◽  
pp. 96-120
Author(s):  
O. M. HELFF
Keyword(s):  
Great Majority ◽  
Gill Tissue ◽  
Shoulder Girdle ◽  
The Other ◽  
Histological Structure ◽  
Serial Sections ◽  
Stages Of Development ◽  
Amphibian Metamorphosis ◽  
The Right ◽  
Made In

(1) Opercular integument, homoplastically transplanted to the back and side of R. temporaria larvae, underwent a process of partial degeneration. The histolysis was not confined to any localized region of the transplant. (2) Autoplastic transplantation of opercular integument to the back and side produced a variety of results. Normal histological structure was maintained in certain transplants, generalized degeneration was observed in others, while in several instances localized histolysis resulting in perforation formation occurred. (3) Homoplastic and autoplastic transplantation of back and side skin to the opercular region resulted in histolysis and perforation formation in such transplants during larval involution. (4) The right forelimbs (in early stages of development) with attached portions of the shoulder girdle were extirpated in R. temporaria and B. bufo. During subsequent metamorphosis, normal opercular histolysis followed by perforation formation in many cases was observed. In most instances, serial sections of the peribranchial cavity revealed the absence of cutaneous glands. (5) Extirpation of the right forelimb only was made in the same two species. Opercular histolysis subsequently occurred in all instances, resulting in perforation formation in the great majority of cases during larval involution. In many of the B. bufo animals two separate perforations developed, one filled with limb stump and the other with gill tissue. (6) It is concluded that in R. temporaria a particular area of the operculum may in some individuals possess self-degenerative potentialities conducive to histolysis and perforation formation during metamorphosis. In both R. temporaria and B. bufo histolytic influences emanating from the atrophying gill tissue and the cutaneous glands of the forelimb are probably also responsible for opercular histolysis and perforation formation. Limb pressure must be considered a supplemental factor. (7) The results are discussed in general and attention called to the fact that opercular histolysis and perforation formation are "doubly assured" in some species and possibly even "triply assured" in others. Emphasis is placed on the evidently wide divergence between species as regards the particular combination of factors responsible for opercular histolysis and perforation formation. Apparently, no one explanation can serve to account for the phenomenon as it occurs in various species of anurans.

Desensitization of the JAK2/STAT5 GH signaling pathway associated with increased CIS protein content in liver of pregnant mice

2005 ◽  
Vol 289 (4) ◽  
pp. E600-E607 ◽  
Author(s):  
Johanna G. Miquet ◽  
Ana I. Sotelo ◽  
Andrzej Bartke ◽  
Daniel Turyn
Keyword(s):  
Protein Content ◽  
Signaling Pathway ◽  
Molecular Mechanisms ◽  
Prolonged Exposure ◽  
Fold Increase ◽  
Pregnant Mouse ◽  
The Other ◽  
Female Rats ◽  
Cytokine Signaling ◽  
Pregnant Mice

Chronic exposure to growth hormone (GH) was related to the desensitization of the JAK2/STAT5 signaling pathway in liver, as demonstrated in cells, female rats, and transgenic mice overexpressing GH. The cytokine-induced suppressor (CIS) is considered a major mediator of this desensitization. Pregnancy is accompanied by an increment in GH circulating levels, which were reported to be associated with hepatic GH resistance, although the molecular mechanisms involved in this resistance are not clearly elucidated. We thus evaluated the JAK2/STAT5b signaling pathway and its regulation by the suppressors of cytokine signaling (SOCS)/CIS family and the JAK2-interacting protein SH2-Bβ in pregnant mouse liver, a model with physiological prolonged exposure to high GH levels. Basal tyrosyl phosphorylation levels of JAK2 and STAT5b in pregnant mice were similar to values obtained for virgin animals, in spite of the important increment of GH they exhibit. Moreover, these signaling mediators were not phosphorylated upon GH stimulation in pregnant mice. A 3.3-fold increase of CIS protein content was found for pregnant mice, whereas the abundance of the other SOCS proteins analyzed and SH2-Bβ did not significantly change compared with virgin animals. The desensitization of the JAK2/STAT5b GH signaling pathway observed in pregnant mice would then be mainly related to increased CIS levels rather than to the other regulatory proteins examined.

scholarly journals GANGGUAN PEMBENTUKAN ATAP BUMBUNG NEURAL EMBRIO MENCIT AKIBAT INDUKSI 2-ME YANG BERTEPATAN DENGAN MASA NEURULASI PRIMER

2008 ◽  
Vol 13 (2) ◽  
pp. 163-172
Author(s):  
Eko Prihiyantoro ◽  
Win Darmanto ◽  
Samekto Wibowo ◽  
Mammed Sagi ◽  
Sri Kadarsih Soedjono
Keyword(s):  
Neural Tube ◽  
Pregnant Mouse ◽  
The Other ◽  
External Morphology ◽  
Control Group ◽  
Other Hand ◽  
Histological Preparation ◽  
Hand Control ◽  
Neural Axis ◽  
Pregnant Mice

The objective of this study was to determine time of neural fold fusion at dorsal mid line neural axis after treatment 2-methoxyethanol (2-ME) to pregnant mouse during neurulation period and to observe relation process of point of neural fold fusion. Mice at 08:05 gestational days treatment with 2-ME dose 7.5 mmol/kg bw on the other hand control group injected with aqua bidest. Pregnant mice at 08:12, 09:00, 09:12 was sacrificed by dislocation cervix. Embryo was collected after observe with dissecting microscope for external morphology and fixation in Bouin solution and buffer formalin for histological preparation and immunohistochemistry process. Result showed that there was failure of first point neural fold fusion at junction of perspective fore brain and mid brain. The failure of neural fold fusion was caused by increasing apoptosis neuroepithelium. There were no relation process between first point of neural fold fusion and second point or another point of fusion. Failure of first point fusion not cause failure another point of fusion. Observation at 09:12 gestational days showed that the only first point fusion was still open but formation of another part neural tube have finished.

The New Extremists of the Right

Worldview ◽  
1962 ◽  
Vol 5 (5) ◽  
pp. 3-6
Author(s):  
Richard Horchler
Keyword(s):  
New York ◽  
The Other ◽  
Rapid Rate ◽  
Daily News ◽  
National Review ◽  
John Birch Society ◽  
The Right ◽  
Political Figure

If the ultra-rightist balloon has not already burst, it is at least losing its air at a rapid rate. Together with the other ultra-right anti-Communist crusader groups, the John Birch Society has been condemned by every important political figure in the nation, even Barry Goldwater; by spokesmen and official bodies representing all the major religions, including Catholics, Baptists and evangelicals; by every newspaper and magazine that is not itself an avowed part of the extremist-right propaganda apparatus, even such as the New York Daily News and William F. Buckley's National Review.

A Little Like Reading: Preference, Facebook, and Overwhelmed Interpretations

PMLA ◽  
2013 ◽  
Vol 128 (1) ◽  
pp. 201-206 ◽  
Author(s):  
Michael Cobb
Keyword(s):  
New York ◽  
Herman Melville ◽  
New York Times ◽  
Emily Dickinson ◽  
The Other ◽  
Whole Body ◽  
Slide Projector ◽  
Anne Carson ◽  
The World ◽  
The Right

Somehow, of late I had got into the way of involuntarily using the word “prefer” upon all sorts of not exactly suitable occasions. And I trembled to think that my contact with the scrivener had already seriously affected me in a mental way. And what further and deeper aberration might it not yet produce?—Herman Melville, “Bartleby the Scrivener” (22-23)His brain was jerking forward likea bad slide projector. Hesaw the doorwaythe house the night the world andon the other side of the world somewhere Herakles laughing drinking gettinginto a car and Geryon'swhole body formed one arch of a cry—upcast to that custom, the human customof wrong love.—Anne Carson, Autobiography of Red (75)Like eyes that looked on Wastes—Incredulous of OughtBut Blank—and steady Wilderness—Diversified by Night—Just Infinites of Nought—As far as it could see—So looked the face I looked upon—So looked itself—on Me—I offered it no Help— Because the Cause was Mine—The Misery a CompactAs hopeless—as divine—Neither—would be absolved—Neither would be a QueenWithout the Other—Therefore—We perish—tho' We reign——Emily Dickinson, poem 693Herman Melville, Anne Carson, and Emily Dickinson. These authors' bits of language just claimed me as I stared at some books on my office shelf, and I'm not sure exactly what to make of these passages except that I like them. So I'm listing them for you. You might also like them. I like many things, and in no particular order. For instance, here's what I “liked” one day, not long ago, on Facebook: a picture of the word Puppies! scrawled on a sidewalk; a New York Times story about the disorganization of the bicentennial of the War of 1812 (that war has a huge, nearly comical significance in my adopted country of Canada—did you know that Canadians burned down the White House?); an audio clip of Justin Bieber, featuring Busta Rhymes, singing “Little Drummer Boy”; my friend and colleague Jordan Stein's “vegan homo Thanksgiving” photo album; a posting by my “friend” “Emily Dickinson”; numerous updates about and images of the November 2011 pepper spraying of protesting students on the University of California, Davis, campus. I could go on and on, which is probably one of the reasons I, and millions of others, go on and on Facebook. Disorderly is the right word, but the likes are not quite random. People have generated these items, these virtual objects of interest, for rapid public consumption and, with the ubiquity of the “Like” button, for rapid public response. They (we) put stuff out there in part because we're showing off our preferences, or if not our preferences (even though they will be acknowledged with our liking) then at least things that interest us and (we hope) others. It's hard to know exactly what liking something on Facebook means because a like is nearly the same thing as an acknowledgment, something that says, “Yes, I clicked on this item, and it did not displease me.” And often people complain in comments that they wish there were variations on the “Like” button (“I want to express my anger with this piece of information—I wish there were a ‘Hate’ button”). Whatever our motivations or the nature of our interest in what we curate for the world on Facebook, these objects for consumption often go under the heading of like; so, like it or not, we're reading for like—we're doing a little like reading.

Review: Islam and politics in Iranian Kurdistan at a time of revolution: the life of Ahmad Moftizadeh

2017 ◽  
Vol 5 (1) ◽  
pp. 80-87
Author(s):  
Martin Van Bruinessen
Keyword(s):  
New York ◽  
Middle East ◽  
Political Order ◽  
The Other ◽  
Islam And Politics ◽  
Cultural Rights ◽  
Revolutionary Regime

Ali Ezzatyar, The Last Mufti of Iranian Kurdistan: Ethnic and Religious Implications in the Greater Middle East. New York: Palgrave Macmillan, 2016. xv + 246 pp., (ISBN 978-1-137-56525-9 hardback).For a brief period in 1979, when the Kurds had begun confronting Iran’s new Islamic revolutionary regime and were voicing demands for autonomy and cultural rights, Ahmad Moftizadeh was one of the most powerful men in Iranian Kurdistan. He was the only Kurdish leader who shared the new regime’s conviction that a just social and political order could be established on the basis of Islamic principles. The other Kurdish movements were firmly secular, even though many of their supporters were personally pious Muslims.

From the New York Herald to the Italian screen

2017 ◽  
Vol 3 (2) ◽  
pp. 175-193 ◽  
Author(s):  
Katherine Frances Nagels
Keyword(s):  
New York ◽  
The Other ◽  
Comic Strip ◽  
Women In The Workplace

The popular 1907–9 American newspaper comic strip character Fluffy Ruffles was an iconic embodiment of contemporary American femininity between the eras of the Gibson Girl and the later flapper and “it” girl. This article discusses Fluffy Ruffles as a popular phenomenon and incarnation of anxieties about women in the workplace, and how she underwent a metamorphosis in the European press, as preexisting ideas of American youth, wealth, and liberty were grafted onto her character. A decade after her debut in the newspapers, two films—Augusto Genina's partially extant Miss Cyclone (La signorina Ciclone,1916), and Alfredo Robert's lost Miss Fluffy Ruffles (1918)—brought her to the Italian screen. This article looks at how the character was interpreted by Suzanne Armelle and Fernanda Negri Pouget, respectively, drawing on advertisements and the other performances of Negri Pouget to reconstruct the latter. The article is illustrated with drawings and collages based on the author's research.

HUMAN URINARY GONADOTROPHINS ASSAYED BY DIFFERENT RESPONSES IN THE SAME ANIMAL

1960 ◽  
Vol XXXIV (III) ◽  
pp. 375-389 ◽  
Author(s):  
P. S. Brown
Keyword(s):  
Postmenopausal Women ◽  
Ovarian Response ◽  
The Other ◽  
Relative Potency ◽  
Vaginal Opening ◽  
Serial Sections ◽  
Immature Female ◽  
Female Mice ◽  
Marked Disparity ◽  
Relative Potencies

ABSTRACT Selected human urinary gonadotrophins were assayed against one another using various measures of response in the same immature female mice. Intact or hypophysectomized animals were used and in some experiments the results of hypophysectomy were checked in complete serial sections. Extracts from the urine of two subjects with Turner's syndrome were compared. In intact mice, the relative potency judged by the ovarian response differed from that shown by the uterine response and the 95 % fiducial limits of the two estimates did not overlap. When the mice were hypophysectomized, one extract became much less potent while the other did not. Similar differences were shown in the response of intact mice to urinary extracts from two subjects with Klinefelter's syndrome. There was a marked disparity between the relative potencies shown by the uterine response and by the incidence of vaginal opening. Similar differences were not shown between the responses to different extracts from the urine of normal postmenopausal women, but these extracts were known to differ little in quality. The results are interpreted in terms of qualitative differences between human urinary gonadotrophins.

PENYALAHGUNAAN HAK KEKEBALAN DIPLOMATIK DITINJAU DARI KONVENSI WINA 1961 (STUDI KASUS PENYELUNDUPAN EMAS OLEH PEJABAT DIPLOMATIK KOREA UTARA DI BANGLADESH)

2019 ◽  
Vol 1 (1) ◽  
pp. 81-94
Author(s):  
Komang Sukaniasa
Keyword(s):  
New York ◽  
North Korea ◽  
Vienna Convention ◽  
Diplomatic Relations ◽  
Special Power ◽  
New York Convention ◽  
Diplomatic Immunity ◽  
The Right ◽  
State Representatives

Diplomatic officials are state representatives in developing diplomatic relations with other countries where it is accredited. Diplomatic officials have the rights of immunity and privileges granted by the sending country. Besides enjoying these rights, diplomatic officials also have obligations. As a diplomatic official from North Korea, Son Young Nam is obliged to obey the rules contained in the 1961 Vienna Convention, the 1969 New York Convention, and to respect the national law of the country of Bangladesh which is the country where he was accredited. Son Young Nam's smuggling of gold into Bangladesh was a form of abuse of diplomatic immunity. The act violated Articles 27 and 41 (1) of the 1961 Vienna Convention and Article 25b of The Special Power Act of Bangladesh. Although they have the right to immunity, these rights are not absolute. Immune rights can be breached in the event of gross violations committed by diplomatic officials.

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