scholarly journals The histochemical demonstration of gamma-glutamyl transpeptidase activity in different populations of rat liver during azo dye carcinogenesis.

1982 ◽  
Vol 30 (4) ◽  
pp. 312-316 ◽  
Author(s):  
R Daoust
Keyword(s):  
Bile Duct ◽  
Azo Dye ◽  
Histochemical Demonstration ◽  
Cell Populations ◽  
Liver Lesions ◽  
Cell Type ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Different Populations ◽  
Glutamyl Transpeptidase

To better assess the reliability of gamma-glutamyl transpeptidase (gamma-GTase) as a marker of preneoplastic liver lesions and hepatomas, the gamma-GTase activity of different cell populations was examined in liver sections from rats fed 4-dimethylaminoazobenzene. The results indicated that the biliary ductular cells in trabeculae of cirrhotic livers may exhibit appreciable gamma-GTase activity in addition to that shown by islands of regenerating parenchyma. At later stages of azo dye carcinogenesis, the epithelial cells of bile duct cysts and cholangiomas, as well as those of hepatomas, gave positive reactions for gamma-GTase. Thus biochemical data on liver gamma-GTase in different models of hepatocarcinogenesis cannot be translated directly in terms of alterations in a particular cell type unless such interpretation is justified by parallel histochemical investigations.

scholarly journals Pattern and rate of disappearance of gamma-glutamyl transpeptidase activity in fetal and neonatal rat liver.

1983 ◽  
Vol 31 (11) ◽  
pp. 1312-1316 ◽  
Author(s):  
P M Iannaccone ◽  
J Koizumi
Keyword(s):  
Amino Acid ◽  
Bile Duct ◽  
Neonatal Rat ◽  
Acid Transport ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Duct Epithelium ◽  
Neonatal Liver ◽  
Bile Duct Epithelium ◽  
Glutamyl Transpeptidase

Gamma-glutamyl transpeptidase (gamma-GTP), an amino acid transport enzyme, has been demonstrated in a number of fetal and adult tissues of rodent and man. While the re-expression of the enzyme has been described in epithelia following carcinogen treatment or aging, little is known of the mechanism of its disappearance in some neonatal tissues. A description is presented of the rate and pattern of loss of histologically demonstrable gamma-GTP activity from fetal and neonatal liver of the rat. The number of hepatocytes with histologically demonstrable gamma-GTP activity declines rapidly from the 18th day of gestation. By the 6th day postpartum the activity is demonstrable in clusters of hepatocytes. By the 7th day postpartum there are essentially no hepatocytes with demonstrable activity, although the enzyme remains expressed in bile duct epithelium.

Histochemical Demonstration of Gamma-Glutamyl Transpeptidase

Nature ◽  
1961 ◽  
Vol 191 (4790) ◽  
pp. 767-768 ◽  
Author(s):  
Z. ALBERT ◽  
MARIAN ORLOWSKI ◽  
A. SZEWCZUK
Keyword(s):  
Histochemical Demonstration ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Relationship Between Gamma-glutamyl Transpeptidase Activity and Inflammatory Response in Lichen Planus

2018 ◽  
Vol 69 (3) ◽  
pp. 739-743 ◽  
Author(s):  
Madalina Irina Mitran ◽  
Ilinca Nicolae ◽  
Corina Daniela Ene ◽  
Cristina Iulia Mitran ◽  
Clara Matei ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Lichen Planus ◽  
Inflammatory Process ◽  
Molecular Mechanisms ◽  
Functional Adaptation ◽  
Physical Factors ◽  
Inflammatory Disorder ◽  
Gamma Glutamyl Transpeptidase ◽  
Gamma Glutamyl ◽  
Glutamyl Transpeptidase

Chemicals used in the manufacture of synthetic fibers have been associated with undesirable side effects such as itching or skin lesions and it seems that they are involved in the induction of pathological processes such as oxidative stress and inflammation. Lichen planus (LP) can be regarded as an inflammatory disorder, chemical and physical factors playing an important role in the perpetuation of the inflammatory process. Gamma-glutamyl transpeptidase (GGT) plays an important role in the preservation of skin architecture and modulation of skin inflammation. In this study, we found that GGT activity is increased in LP patients with mild inflammation, whilst GGT is inactivated under conditions of severe inflammation. Therefore, GGT is involved in the inflammatory process, but there is no a positive correlation between its activity and the intensity of the inflammatory response. This functional adaptation of the enzyme may be due to down-regulation of its synthesis under free radical overload conditions. Understanding the molecular mechanisms involved in the modulation of intracellular redox homeostasis is an important step in the pharmacological management of patients with LP.

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