Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population

2010 ◽  
Vol 4 (4) ◽  
pp. 223-230 ◽  
Author(s):  
Benedetta D. Chiodini ◽  
Claudia Specchia ◽  
Francesca Gori ◽  
Simona Barlera ◽  
Andria D'Orazio ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Association Study ◽  
Gene Polymorphisms ◽  
Italian Population ◽  
Adiponectin Gene

Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population

Gene ◽  
2018 ◽  
Vol 662 ◽  
pp. 118-122 ◽  
Author(s):  
Majid Kadhum Hussain ◽  
Falah Abdulhasan Deli ◽  
Abdul Hussein A. Algenabi ◽  
Khalid H. Abdul-Rudha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Adiponectin Gene

scholarly journals Interleukin-18 Promoter Gene Polymorphisms are not Associated with Myocardial Infarction in Type 2 Diabetes in Slovenia

2011 ◽  
Vol 14 (1) ◽  
pp. 3-9 ◽  
Author(s):  
S Kariž ◽  
D Petrovič
Keyword(s):  
Myocardial Infarction ◽  
Type 2 Diabetes ◽  
Gene Polymorphisms ◽  
Serum Levels ◽  
Control Group ◽  
Interleukin 18 ◽  
Significant Difference ◽  
Promoter Gene ◽  
The Impact

Interleukin-18 Promoter Gene Polymorphisms are not Associated with Myocardial Infarction in Type 2 Diabetes in SloveniaType 2 diabetes is a major risk factor for myocardial infarction (MI) and chronic inflammation may play a central role in both diseases. Interleukin (IL)-18 is a potent proinflammatory cytokine, which is considered important in acute coronary syndromes and type 2 diabetes. We investigated the association of the -137 (G>C), polymorphism (rs187238) and the -607 (C<A) polymorphism (rs1946518) of the IL-18 gene promoter region in 495 Caucasians with type 2 diabetes, of whom 169 had MI and 326 subjects had no clinically evident coronary artery disease (controls). We also investigated the impact of these polymorphisms on the serum IL-18 level in subsets of both groups and in a normal group. Genotype distributions of the polymorphisms showed no significant difference between cases and controls. However, IL-18 serum levels were significantly lower in diabetics with the137 CC genotype than in those with other genotypes (241.5 ± 132.7 ng/Lvs.340.2 ± 167.4 ng/L; p <0.05). High sensitivity C-reactive protein and IL-18 serum levels were higher in diabetics in the MI group than in the control group. We conclude that these IL-18 promoter gene polymorphisms are not risk factors for MI in Caucasians with type 2 diabetes.

Association study of SREBF-2 gene polymorphisms and the risk of type 2 diabetes in a sample of Iranian population

Gene ◽  
2018 ◽  
Vol 660 ◽  
pp. 145-150 ◽  
Author(s):  
Hamidreza Galavi ◽  
Nafiseh Noorzehi ◽  
Ramin Saravani ◽  
Saman Sargazi ◽  
Fatemeh Mollashahee-Kohkan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Association Study ◽  
Gene Polymorphisms ◽  
Iranian Population

scholarly journals Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy

Diabetes ◽  
2008 ◽  
Vol 58 (2) ◽  
pp. 499-504 ◽  
Author(s):  
M. A. Bostrom ◽  
B. I. Freedman ◽  
C. D. Langefeld ◽  
L. Liu ◽  
P. J. Hicks ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
African American ◽  
Gene Polymorphisms ◽  
American Population ◽  
Adiponectin Gene ◽  
African American Population
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