scholarly journals Originator of the hormesis concept: Rudolf Virchow or Hugo Schulz

2017 ◽  
Vol 37 (9) ◽  
pp. 889-890 ◽  
Author(s):  
EJ Calabrese
Keyword(s):  
Dose Response ◽  
The Past ◽  
Two Agents ◽  
Biphasic Dose Response

In 2006, Henschler disputed the claim of Calabrese and Baldwin that Hugo Schulz should be considered the originator of the hormesis concept. Henschler cited an 1854 paper by Rudolf Virchow on the effects of two agents on the beating of cilia, which showed a hormetic–biphasic dose response. The interpretation of Henschler became broadly accepted over the past decade based on citations in the literature. However, a recent translation of the Virchow paper from German into English reveals that the claims of Henschler are not supported by the article.

Biphasic Dose/Response of Photobiomodulation Therapy on Culture of Human Fibroblasts

2020 ◽  
Vol 38 (7) ◽  
pp. 413-418
Author(s):  
Genoveva Lourdes Flores Luna ◽  
Ana Laura Martins de Andrade ◽  
Patricia Brassolatti ◽  
Paulo Sérgio Bossini ◽  
Fernanda de Freitas Anibal ◽  
...  
Keyword(s):  
Dose Response ◽  
Human Fibroblasts ◽  
Photobiomodulation Therapy ◽  
Biphasic Dose Response

Biphasic Dose–Response Phenomenon Induced by Xenobiotics and Its Application in Soil Risk Assessment

2017 ◽  
pp. 125-138
Author(s):  
Muhammad Zaffar Hashmi ◽  
Adeel Mehmood ◽  
Sohaib Khan ◽  
Ahmad Hasnain ◽  
Zulkifl Ahmed
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Soil Risk Assessment ◽  
Biphasic Dose Response

Effects of in vivo cholinergic stimulation of rat exocrine pancreas

1983 ◽  
Vol 244 (6) ◽  
pp. G623-G629
Author(s):  
G. Adler ◽  
G. Gerhards ◽  
J. Schick ◽  
G. Rohr ◽  
H. F. Kern
Keyword(s):  
Dose Response ◽  
Exocrine Pancreas ◽  
Pancreatic Enzyme ◽  
Target Cells ◽  
Response Curves ◽  
Cholinergic Agent ◽  
Rat Exocrine Pancreas ◽  
Biphasic Dose Response

Peptide and cholinergic secretagogues both produce biphasic dose-response curves for pancreatic enzyme secretion in vitro: supraoptimal doses result in submaximal secretory responses. We compared the effects of maximal and supramaximal doses of a cholinergic agent (carbachol) on rat exocrine pancreas in vivo. In conscious rats, volume and enzyme output were measured from the cannulated pancreatic duct during infusion of carbachol for 3 h. Infusion of 5 X 10(-7) mol . kg-1 . h-1 carbachol caused optimal stimulation, whereas a supraoptimal dose (5 X 10(-6) mol . kg-1 . h-1) resulted in submaximal response. Similar results were achieved when discharge of amylase and protein synthesis was determined in vitro after carbachol in vivo. Supraoptimal doses of carbachol increased serum amylase and enhanced acinar cell lysosomal activity in the Golgi area. The latter appeared to induce fusion of zymogen granules, which resulted in cytoplasmic vacuoles. The in vivo results corroborate in vitro findings of a biphasic dose-response relationship for carbachol and demonstrate destructive effects of supraoptimal concentrations on target cells.

The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells

2009 ◽  
Vol 23 (4) ◽  
pp. 660-666 ◽  
Author(s):  
Changfu Hao ◽  
Weidong Hao ◽  
Xuetao Wei ◽  
Lina Xing ◽  
Jianjun Jiang ◽  
...  
Keyword(s):  
Dose Response ◽  
Hek293 Cells ◽  
Biphasic Dose Response

scholarly journals Proportion of patients without mental disorders being treated in mental health services worldwide

2015 ◽  
Vol 206 (2) ◽  
pp. 101-109 ◽  
Author(s):  
Ronny Bruffaerts ◽  
Jose Posada-Villa ◽  
Ali Obaid Al-Hamzawi ◽  
Oye Gureje ◽  
Yueqin Huang ◽  
...  
Keyword(s):  
Mental Health ◽  
Mental Disorders ◽  
Mental Disorder ◽  
Dose Response ◽  
Mental Health Treatment ◽  
World Health ◽  
Health Treatment ◽  
The Past ◽  
The World ◽  
Dsm Iv

BackgroundPrevious research suggests that many people receiving mental health treatment do not meet criteria for a mental disorder but are rather ‘the worried well’.AimsTo examine the association of past-year mental health treatment with DSM-IV disorders.MethodThe World Health Organization's World Mental Health (WMH) Surveys interviewed community samples of adults in 23 countries (n = 62 305) about DSM-IV disorders and treatment in the past 12 months for problems with emotions, alcohol or drugs.ResultsRoughly half (52%) of people who received treatment met criteria for a past-year DSM-IV disorder, an additional 18% for a lifetime disorder and an additional 13% for other indicators of need (multiple subthreshold disorders, recent stressors or suicidal behaviours). Dose–response associations were found between number of indicators of need and treatment.ConclusionsThe vast majority of treatment in the WMH countries goes to patients with mental disorders or other problems expected to benefit from treatment.

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