Parenteral MCT/ω-3 Polyunsaturated Fatty Acid–Enriched Intravenous Fat Emulsion Is Associated With Cytokine and Fatty Acid Profiles Consistent With Attenuated Inflammatory Response in Preterm Neonates

2015 ◽  
Vol 31 (2) ◽  
pp. 235-244 ◽  
Author(s):  
Maria Skouroliakou ◽  
Dimitris Konstantinou ◽  
Charalampos Agakidis ◽  
Andriana Kaliora ◽  
Nick Kalogeropoulos ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Inflammatory Response ◽  
Polyunsaturated Fatty Acid ◽  
Preterm Neonates ◽  
Fatty Acid Profiles ◽  
Fat Emulsion ◽  
Intravenous Fat Emulsion

scholarly journals Administration of an Intravenous Fat Emulsion Enriched with Medium-Chain Triglyceride/ω-3 Fatty Acids is Beneficial Towards Anti-Inflammatory Related Fatty Acid Profile in Preterm Neonates: A Randomized, Double-Blind Clinical Trial

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3526
Author(s):  
Panos Papandreou ◽  
Aristea Gioxari ◽  
Dimitrios Ntountaniotis ◽  
Olga-Natalia Korda ◽  
Maria Skouroliakou ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Linoleic Acid ◽  
Soybean Oil ◽  
Medium Chain Triglyceride ◽  
Preterm Neonates ◽  
Control Group ◽  
Fat Emulsion ◽  
Double Blind ◽  
Intravenous Fat Emulsion ◽  
Medium Chain

Intravenous administration of pure soybean oil emulsions high in linoleic acid may lead to inflammation and lipid peroxidation in preterm neonates. We aimed to investigate the effects of a medium-chain triglyceride (MCT)/ω-3 polyunsaturated fatty acid (PUFA)-enriched intravenous fat emulsion (IVFE) on plasma fatty acid (FA) profile and serum interleukin-6 (IL-6) in preterm neonates. In this double-blind randomized study, 92 preterm neonates (gestational age < 32 weeks, birth weight < 1500 g) were assigned to receive either MCT/ω-3 PUFA-enriched IVFE (Intervention Group) or soybean oil-based IVFE (Control Group). Levels of FAs were measured at baseline (day 0) and day 15 of parenteral nutrition with gas-chromatography mass-spectrometry. Serum IL-6 was measured with sandwich ELISA in 59 neonates. Plasma FAs changed significantly over time; the MCT/ω-3 PUFA-IVFE group showed higher ω-3 PUFAs (p = 0.031), eicosapentaenoic acid (p = 0.000), and oleic acid (p = 0.003), and lower ω-6/ω-3 PUFAs ratio (p = 0.001) and ω-6 PUFAs (p = 0.023) compared to control group. Linoleic acid was higher in the soybean oil (SO)-based IVFE arm compared to the MCT/ω-3 PUFAs-IVFE arm (p = 0.006). Both fat emulsion types decreased IL-6 compared to baseline, but changes were insignificant between groups. Administration of MCT/ω-3 PUFA-enriched IVFE in preterm neonates is beneficial in changing the FA profile consistent with attenuated inflammatory response.

scholarly journals Diet Supplementation in ω3 Polyunsaturated Fatty Acid Favors an Anti-Inflammatory Basal Environment in Mouse Adipose Tissue

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 438 ◽  
Author(s):  
Cecilia Colson ◽  
Rayane Ghandour ◽  
Océane Dufies ◽  
Samah Rekima ◽  
Agnès Loubat ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Inflammatory Response ◽  
Polyunsaturated Fatty Acids ◽  
Polyunsaturated Fatty Acid ◽  
Inflammatory Cytokine ◽  
M2 Macrophage ◽  
Anti Inflammatory ◽  
Diet Supplementation

Oxylipins are metabolized from dietary ω3 and ω6 polyunsaturated fatty acids and are involved in an inflammatory response. Adipose tissue inflammatory background is a key factor of metabolic disorders and it is accepted that dietary fatty acids, in terms of quality and quantity, modulate oxylipin synthesis in this tissue. Moreover, it has been reported that diet supplementation in ω3 polyunsaturated fatty acids resolves some inflammatory situations. Thus, it is crucial to assess the influence of dietary polyunsaturated fatty acids on oxylipin synthesis and their impact on adipose tissue inflammation. To this end, mice fed an ω6- or ω3-enriched standard diet (ω6/ω3 ratio of 30 and 3.75, respectively) were analyzed for inflammatory phenotype and adipose tissue oxylipin content. Diet enrichment with an ω3 polyunsaturated fatty acid induced an increase in the oxylipins derived from ω6 linoleic acid, ω3 eicosapentaenoic, and ω3 docosahexaenoic acids in brown and white adipose tissues. Among these, the level of pro-resolving mediator intermediates, as well as anti-inflammatory metabolites, were augmented. Concomitantly, expressions of M2 macrophage markers were increased without affecting inflammatory cytokine contents. In vitro, these metabolites did not activate macrophages but participated in macrophage polarization by inflammatory stimuli. In conclusion, we demonstrated that an ω3-enriched diet, in non-obesogenic non-inflammatory conditions, induced synthesis of oxylipins which were involved in an anti-inflammatory response as well as enhancement of the M2 macrophage molecular signature, without affecting inflammatory cytokine secretion.

Alterations in growth and fatty acid profiles under stress conditions of Hansenula polymorpha defective in polyunsaturated fatty acid synthesis

2013 ◽  
Vol 40 (8) ◽  
pp. 4935-4945 ◽  
Author(s):  
Sarintip Sooksai ◽  
Pattsarun Chewchanlertfa ◽  
Yoshinobu Kaneko ◽  
Satoshi Harashima ◽  
Kobkul Laoteng
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Hansenula Polymorpha ◽  
Acid Synthesis ◽  
Stress Conditions ◽  
Fatty Acid Profiles
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