Treatment of the Psychiatric Manifestations of Huntington's Disease: A Review of the Literature

1998 ◽  
Vol 43 (9) ◽  
pp. 933-940 ◽  
Author(s):  
Iracema Leroi ◽  
Max Michaion
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Review Of The Literature ◽  
Psychiatric Manifestations

“organic Personality Disorder” as Part of Early Neuropsychiatric Manifestations in Huntington’s Disease - a Case Report

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Maia
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Psychiatric Symptoms ◽  
Age Of Onset ◽  
Neuropsychiatric Symptoms ◽  
Personality Change ◽  
Psychotic Symptoms ◽  
Autosomal Dominant Disorder ◽  
Neuropsychiatric Manifestations ◽  
Psychiatric Manifestations

Huntington's Disease (HD) is an inherited autosomal dominant disorder characterized by motor, cognitive and psychiatric symptomatology, being considered a paradigmatic neuropsychiatric disorder that includes all three components of the "Triadic Syndromes": dyskinesia, dementia and depression.Firstly described in 1872 as an "Hereditary Chorea" by George Huntington only in 1993 was its responsible gene identified. A person who inherits the HD gene will sooner or later develop the disease. the age of onset, early signs and rate of disease progression vary greatly from person to person.Neuropsychiatric symptoms are an integral part of HD and have been considered the earliest markers of the disease, presenting sometimes more than 10 years before a formal diagnosis is done. Patients may experience dysphoria, mood swings, agitation, irritability, hostile outbursts, psychotic symptoms and deep bouts of depression with suicidal ideation. Personality change is reported in 48% of the cases, with the paranoid subtype being described as the most prevalent. the clinical case presented illustrates a case of HD which started with insidious psychiatric symptoms and an important personality change.Despite a wide number of medications being prescribed to help control emotional, movement and behaviour problems, there is still no treatment to stop or reverse the course of the disease. Furthermore, psychiatric manifestations are often amenable to treatment, and relief of these symptoms may provide significant improvement in patient's and caregivers quality of life.A greater awarness of psychiatric manifestations of HD is essential to an earlier diagnosis and an optimized therapeutic approach.

scholarly journals The Prevalence of Juvenile Huntington's Disease: A Review of the Literature and Meta-Analysis

PLoS Currents ◽  
2012 ◽  
Vol 4 ◽  
pp. e4f8606b742ef3 ◽  
Author(s):  
Oliver Quarrell ◽  
Kirsty L O'Donovan ◽  
Oliver Bandmann ◽  
Mark Strong
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Meta Analysis ◽  
Review Of The Literature ◽  
Juvenile Huntington’S Disease

scholarly journals Electroconvulsive therapy for severe depression, psychosis and chorea in a patient with Huntington's disease: case report and review of the literature

2020 ◽  
pp. 1-8
Author(s):  
Walied Mowafi ◽  
Jon Millard
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Electroconvulsive Therapy ◽  
Severe Depression ◽  
Good Control ◽  
Psychomotor Retardation ◽  
Pharmacological Therapy ◽  
Conflicting Evidence ◽  
Disease Case ◽  
Psychiatric Manifestations

Aims and method The psychiatric manifestations of Huntington's disease are myriad and difficult to control. The use of electroconvulsive therapy (ECT) is not commonly considered for this condition. We describe a patient with severe depression, psychomotor retardation, delusions and weight loss who responded to ECT with good control of her symptoms. Results Both our case and the literature appear to confirm the efficacy of ECT in the treatment of depression in Huntington's disease and suggest that other psychiatric manifestations of Huntington's are also responsive. Clinical implications ECT is an effective and safe treatment that should be considered earlier in the course of the disease in cases that show limited response to pharmacological therapy. It should also be considered as an adjunct to medical therapy that may simplify polypharmacy and allow better control in patients with debilitating psychiatric manifestations of the disease. There is limited and conflicting evidence for its efficacy in chorea.

Huntington's disease: a review of the literature on prevalence and treatment of neuropsychiatric phenomena

2001 ◽  
Vol 16 (8) ◽  
pp. 439-445 ◽  
Author(s):  
P. Naarding ◽  
H.P.H. Kremer ◽  
F.G. Zitman
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Classification System ◽  
Brain Function ◽  
Neuropsychological Functioning ◽  
Future Research ◽  
Clinical Neurology ◽  
Review Of The Literature ◽  
Genetic Mechanisms ◽  
The Subject

SummaryA review was made of the literature on Huntington’s disease, including the clinical neurology, recent advances in pathophysiology and genetic mechanisms and psychopathology. It can be concluded that research on the latter is scarce, although the subject is relevant because of the co-occurrence of psychiatric, neurological and genetic phenomena, which may lead to novel concepts in the understanding of brain function. So far, attempts to provide a comprehensive and pragmatic description of the psychopathology of Huntington’s disease have been disappointing, probably due to the limitations of the DSM classification system in this disorder. Future research should focus not only on this classification system, but also on neuropsychological functioning, because of the degenerative nature of the disease. Systematic and controlled studies should be performed on the treatment of psychiatric abnormalities in Huntington’s disease before any conclusions can be drawn.

scholarly journals Periodontitis determining the onset and progression of Huntington's disease: review of the literature

Medwave ◽  
2015 ◽  
Vol 15 (09) ◽  
pp. e6293-e6293
Author(s):  
María Lourdes Rodríguez Coyago ◽  
Victoria Emilia Sánchez Temiño
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Review Of The Literature
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