Colloidal Silicic Acid for the Treatment of Psoriatic Skin Lesions, Arthropathy and Onychopathy. A Pilot Study

1997 ◽  
Vol 25 (4) ◽  
pp. 206-209 ◽  
Author(s):  
A Lassus
Keyword(s):  
Silicic Acid ◽  
Skin Irritation ◽  
Skin Lesions ◽  
Treated Group ◽  
Psoriatic Skin ◽  
Double Blind Study ◽  
Double Blind ◽  
Psoriatic Arthropathy ◽  
Plaque Type ◽  
Acid Gel

In a randomized, double-blind study, patients with chronic plaque-type psoriasis were either treated with 30 ml colloidal silicic acid gel, orally, daily, and topically with the same gel ( n = 15), or were treated identically with placebo gel ( n = 15) for 3 months. One stable psoriatic lesion on the knee or elbow was treated topically and followed throughout the study. Five patients in the treated group and seven controls had psoriatic arthropathy and 11 treated patients and 12 controls had psoriatic onychopathy. Three treated patients and six controls withdrew because of skin irritation or lack of efficacy. In the treated group there were clear improvements in scaling, induration and erythema after treatment. The nail changes were cured in five of 10 evaluable patients in the treated group and joint pain was reduced by almost half in the four evaluable patients with arthropathy. There were no such improvements in the placebo group.

STUDIES OF TOCOPHEROL DEFICIENCY IN INFANTS AND CHILDREN

PEDIATRICS ◽  
1961 ◽  
Vol 27 (4) ◽  
pp. 578-588
Author(s):  
Stanley Levin ◽  
Mordecai H. Gordon ◽  
Harold M. Nitowsky ◽  
Carmen Goldman ◽  
Paul di Sant'Agnese ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Muscle Strength ◽  
Treated Group ◽  
Muscle Disease ◽  
Tocopheryl Acetate ◽  
Double Blind Study ◽  
Double Blind ◽  
Quantitative Measurements ◽  
Clinical Conditions ◽  
Group Serum

A bulb ergographic method for estimating muscle strength was modified to permit quantitative measurements. Studies in a group of 13 convalescent children without muscle disease established the reliability of the method for repeated observations. Forty-five patients with cystic fibrosis, whose clinical conditions appeared stable, were accepted in a double-blind study comparing the effect of tocopherol or a placebo on serum tocopherol, S-GOT, weight gain, subjective improvement, and muscle strength as measured by the ergograph. Measurements were made at the beginning of the study, and 2 and 6 months after beginning tocopheryl acetate (10 mg/kg/day) or placebo therapy. Although statistically significant increases in serum tocopherol, weight, muscle strength, and clinical improvement were found at 2 and 6 months after beginning of the study, there were no significant differences between the two groups, except in serum content of tocopherol. In the tocopherol treated group, serum tocopherol became normal (0.83 to 1.05 mg/100 ml), but remained low (0.20 to 0.33 mg/100 ml) in the placebo group. Although the present study did not demonstrate a clinical functional effect of tocopherol therapy in patients with cystic fibrosis, its administration is recommended because of previously reported biochemical and pathologic evidence of vitamin E deficiency in these subjects.

A Double-Blind Out-Patient Trial of Indalpine vs Mianserin

1985 ◽  
Vol 147 (3) ◽  
pp. 306-309 ◽  
Author(s):  
G. J. Naylor ◽  
B. Martin
Keyword(s):  
Side Effects ◽  
Treated Group ◽  
Blind Study ◽  
Antidepressant Effect ◽  
Double Blind Study ◽  
Double Blind ◽  
Significant Difference

SummaryIndalpine 150 mg per day and mianserin 60 mg per day were compared in a double-blind study of 65 depressed out-patients: 52 patients completed the 4-week trial. At the end of four weeks there was no significant difference in antidepressant effect between the two drugs; but in the first two weeks, improvement in the mianserin-treated group was significantly greater than that in the indalpine group. The mianserin-treated group reported more side-effects of sedation (eg. drowsiness, clumsiness, heaviness of limbs etc.) and one patient on indalpine developed a mild leucopenia.

Clinical Evaluation Of Ticlopidine In The Inhibition Of Platelet Function - A Multiclinic Double Blind Study In Comparison With Aspirin

1981 ◽  
Author(s):  
T Abe ◽  
A Kuramoto ◽  
K Yasunaga ◽  
N Sakuragawa ◽  
T Maekawa ◽  
...  
Keyword(s):  
Clinical Effect ◽  
Laboratory Data ◽  
Treated Group ◽  
Double Blind Study ◽  
Double Blind ◽  
Aggregation Pattern ◽  
Daily Dose ◽  
Microcirculatory Disorders ◽  
Thrombotic Diseases ◽  
Aspirin Group

Clinical effect of ticlopidine, a new inhibitor of platelet aggregation, at a daily dose of 300 mg was compared with that of aspirin at its daily dose of 500 mg by means of double blind assay. The suppression of platelet aggregations induced by ADP, collagen and epinephrine was compared among platelet samples obtained from 38 cases with thrombotic tendency or at enhanced platelet functions.The inhibitory efficacy of ticlopidine on platelet aggregations induced by collagen or epinephrine was found as potent as that of aspirin in their overall judgement, but the ticlopidine inhibition on the ADP aggregation was apparently more potent than aspirin. The maximum aggregation rate was significantly decreased and the frequency of the second aggregation pattern was more remarkably minimized in the ticlopidine-treated group than the aspirin-group. The maximum aggregation rates induced by collagen or epinephrine were significantly decreased in both of ticlopidine- and aspirin-groups to the same extent.Blood filtration velocity through Nuclepore filter of 5μm pore size was significantly enhanced in the ticlopidine- group but no change found in the aspirin-group. Other coagulation parameters and laboratory data were not changed in both groups, except bleeding and prothrombin times which were slightly prolonged in the aspirin-group.From the results mentioned above, it was expected that ticlopidine might exert superior clinical effect to aspirin on thrombotic diseases and microcirculatory disorders

EFFECT OF ANTIAGGREGANT ON OCCLUSION OF SAPHENOUS GRAFT CORONARY BYPASS

1987 ◽  
Author(s):  
E Lavenne-Pardonge ◽  
C Col-De Beys ◽  
R Dion ◽  
R Ponlot ◽  
M Moriau
Keyword(s):  
Placebo Group ◽  
Coronary Bypass ◽  
Arterial Disease ◽  
Treated Group ◽  
Double Blind Study ◽  
Careful Study ◽  
Double Blind ◽  
Normal Limits ◽  
Group 2 ◽  
Long Acting

Double blind study on 49 patients, 24receiving aspirine-dipyri-damole, 25 a placebo. In both groups 20 patients were followed during one year. The two groupsdid not differ according to age, sex and number of coronary bypass. In all the patients, Calparin (3 x 5000 U/day) was injected subcutanously the day before andthe 7 days after surgery. In the first group dipyridamole (25 mg/ kg) was injected during the same period. The second group received a placebo IV injection. Thereafter long acting dipyridamole (400 mg/day) and aspirin (200 mg/day) were given orally in the first group, placebo in the second one. Cardiac follow-up included E.C.G. and thallium at maximum exercise. Coronarography was performed only incase of reappearence of chest pain. No difference was found between the two groups for the coagulation parameters duringthe whole year of study. Statistically significant differences between the two groups were found during the same period for β-thromboglobulin, fibrino-peptide A and the ratio Δ+ βTG/Δ+ FPA. Plateletactivity, elevated in the placebo group, was kept in normal limits in the treated group. During the two first months for the placebo and during the first month for the treated group the ratio Δ+ βTG/Δ+ FPA decreased in all patients showing the importance at this time of plasmatic hypercoagulability compared to platelet hyperactivity. During the 12 months of the study 5 thrombotic accidents (25 %) were noted in the placebo group (2 myocardial infarctions, 2 occlusions of bypass, 1 case of cerebral arterial disease) and 2 (10 % in the treated group) (1 postoperative death, 1 myocardial infarction) (NS ; p =0,21). Our results lead to two conclusions : 1) Platelet antiaggregants may influencethe permeability of saphenous .graft coronary bypass. A careful study of platelet acti-r vity with eventual change of the drug used may improve the late resultsof surgery. 2) Association of anticoagulant therapy (anti-vitamin K) during the two first months after surgery could also be useful.

A Controlled Comparison of Fluoxetine and Amitriptyline in Depressed Out-patients

1987 ◽  
Vol 151 (3) ◽  
pp. 337-340 ◽  
Author(s):  
J. P. R. Young ◽  
A. Coleman ◽  
M. H. Lader
Keyword(s):  
Sleep Disturbances ◽  
Treated Group ◽  
Blind Study ◽  
Serotonin Uptake ◽  
Dry Mouth ◽  
Selective Serotonin ◽  
Double Blind Study ◽  
Double Blind ◽  
Uptake Inhibitor ◽  
Serotonin Uptake Inhibitor

Fluoxetine, a selective serotonin uptake inhibitor (mean dose 73 mg each morning) was compared with amitriptyline (mean dose 122 mg at night) in a double-blind study of 64 depressed out-patients. Fifty patients completed the 6-week trial. The drugs did not differ with respect to psychiatrists' ratings, but amitriptyline was slightly superior with respect to patients' ratings. The amitriptyline-treated group had complaints of dry mouth and dizziness on standing; the fluoxetine-treated group of sleep disturbances, nausea, and headaches.

Long-term skill proceduralization in schizophrenia

2009 ◽  
Vol 16 (1) ◽  
pp. 148-156 ◽  
Author(s):  
SOPHIE RÉMILLARD ◽  
EMMANUELLE POURCHER ◽  
HENRI COHEN
Keyword(s):  
Semantic Network ◽  
Reading Speed ◽  
Memory Task ◽  
Specific Effect ◽  
Treated Group ◽  
Procedural Memory ◽  
Procedural Learning ◽  
Double Blind Study ◽  
Healthy Controls ◽  
Double Blind

AbstractPrevious studies had revealed no specific effect under haloperidol (typical) and risperidone (atypical) neuroleptic (NLP) treatments for schizophrenia (SZ) on a variety of neurocognitive functions relying on the dopaminergic meso-cortico-limbic system (Rémillard et al., 2005, 2008). Considering the different affinities of D2 dopamine receptors for typical and atypical NLPs, these drugs may differentially affect the functions of the striatum, a determinant brain structure involved in procedural learning. The influence of risperidone (2–6 mg) and haloperidol (2–40 mg) on a nonmotor procedural task involving semantically related pairs of words with inverted letters was investigated in this double-blind study. The performance of 26 patients with SZ, randomly assigned to risperidone or haloperidol, was compared to that of 18 healthy controls at baseline, 3, 6, and 12 months. Results revealed that all patients with SZ exhibited slower reading speed of the word pairs than healthy controls at all assessment periods. In addition, procedural learning – characterized as a significant decrease in the time taken to read aloud the target word pairs – was more impaired in the haloperidol- than in the risperidone-treated group at all assessment periods. Healthy controls showed steady improvement in reading speed over the 12 months of the study, in contrast to SZ patients, who reached a plateau in their capacity to improve mirror-reading skill over time. However, all SZ participants in the study showed near normal learning profiles from exposure to semantic associations embedded in the procedural memory task, providing evidence for the preservation of associative connections in the semantic network of these patients. The observed impairment in procedural learning in SZ may thus reflect, at least in part, the influence of neuroleptic medication on striatal functions. (JINS, 2010, 16, 148–156.)

scholarly journals Soft Tissue Wound Healing by Laser

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Pressure Ulcers ◽  
Monochromatic Light ◽  
Placebo Treatment ◽  
Treated Group ◽  
Healing Time ◽  
Blind Study ◽  
Controlled Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Ulcer Area

Background: In 1967 a few years after the first working laser was invented, Endre Mester in Semmelweis University Budapest, Hungary wanted to find out if laser might cause cancer. He took some mice, shaved the hair off their backs, divided them into two groups and gave a laser treatment with a low powered ruby laser to one group. They did not get cancer and to his surprise the hair on the treated group grew back more quickly than the untreated group. That was how “laser biostimulation” effects were discovered. (Effect of laser on hair Growth of mice (in Hungarian). Mester, E. Szende, B. and Tota, J.G. (1967). Kiserl Orvostud 19. 628- 631). Purpose of the work: The effects of pulsed monochromatic light, with fixed pulsations and wavelengths, on the healing of pressure ulcers were evaluated in this prospective, randomized, controlled study. Method: A placebo-controlled, double-blind study using low energy photon therapy (LLLT) was performed in ten patients with bedsore on the back. Treatment was given three times a week for 10 weeks, using monochromatic (red) optical sources; diode 660nm (GaAl- 660). The patients who were randomized to placebo treatment received sham therapy from an identicalappearing light source from the same delivery system. Results: Ten patients with bedsore were randomized to receive LLLT or placebo therapy. At the conclusion of the study, the percentage of the initial ulcer area remaining unhealed in the LLLT and placebo groups was 24.4% and 84.7%, respectively (P = 0.0008). The decrease in ulcer area (compared to baseline) observed in the LLLT and placebo groups was 193.0 mm2 and 14.7 mm2, respectively (P = 0.0002). One patient dropped out of the study, complaining of lack of treatment efficacy; he was found to be randomized to the placebo group. There were no adverse effects. Conclusions: In this placebo-controlled, double-blind study LLLT was an effective modality for the treatment of bedsore which were resistant to conventional medical management. The results are encouraging as pulsed monochromatic light increased healing rate and shortened healing time. This will positively affect the quality of life in elderly patients with pressure ulcers.

scholarly journals Compound Danshen Dripping Pill for Treating Early Diabetic Retinopathy: A Randomized, Double-Dummy, Double-Blind Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Dan Luo ◽  
Yali Qin ◽  
Wei Yuan ◽  
Hui Deng ◽  
Youhua Zhang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Visual Field ◽  
Treated Group ◽  
Blind Study ◽  
Fundus Photography ◽  
Control Group ◽  
Therapeutic Effects ◽  
Double Blind Study ◽  
Calcium Dobesilate ◽  
Double Blind

This randomized, double-dummy, double-blind study was to observe the therapeutic effects of compound Danshen dripping pill (CDDP) in treating early diabetic retinopathy (DR). All the 57 type 2 diabetes cases in nonproliferative diabetic retinopathy (NPDR) stage were divided into two groups randomly: 28 cases treated with CDDP as the treated group and 29 cases treated with calcium dobesilate as the control group. The best corrected visual acuity (BCVA) in the treated group was significantly improved after treatment when compared to that before treatment (P<0.05). Mean defect (MD) of visual field, hemorrhage area of the fundus, microaneurysm number, fluorescent leakage area, and capillary nonperfusion area evaluated by visual field, fundus photography, and fundus fluorescein angiography in the treated group had the same results as BCVA. However, there was no statistical difference in each index between the two groups. No obvious adverse events with clinical significance occurred. Our present study showed that CDDP has a similar improvement and safety to calcium dobesilate for NPDR. In future DR treatments, CDDP may function as the auxiliary drug.

Sign in / Sign up

Export Citation Format

Share Document