scholarly journals Compound Danshen Dripping Pill for Treating Early Diabetic Retinopathy: A Randomized, Double-Dummy, Double-Blind Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Dan Luo ◽  
Yali Qin ◽  
Wei Yuan ◽  
Hui Deng ◽  
Youhua Zhang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Visual Field ◽  
Treated Group ◽  
Blind Study ◽  
Fundus Photography ◽  
Control Group ◽  
Therapeutic Effects ◽  
Double Blind Study ◽  
Calcium Dobesilate ◽  
Double Blind

This randomized, double-dummy, double-blind study was to observe the therapeutic effects of compound Danshen dripping pill (CDDP) in treating early diabetic retinopathy (DR). All the 57 type 2 diabetes cases in nonproliferative diabetic retinopathy (NPDR) stage were divided into two groups randomly: 28 cases treated with CDDP as the treated group and 29 cases treated with calcium dobesilate as the control group. The best corrected visual acuity (BCVA) in the treated group was significantly improved after treatment when compared to that before treatment (P<0.05). Mean defect (MD) of visual field, hemorrhage area of the fundus, microaneurysm number, fluorescent leakage area, and capillary nonperfusion area evaluated by visual field, fundus photography, and fundus fluorescein angiography in the treated group had the same results as BCVA. However, there was no statistical difference in each index between the two groups. No obvious adverse events with clinical significance occurred. Our present study showed that CDDP has a similar improvement and safety to calcium dobesilate for NPDR. In future DR treatments, CDDP may function as the auxiliary drug.

Effect of calcium dobesilate on progression of early diabetic retinopathy: a randomised double-blind study

2006 ◽  
Vol 244 (12) ◽  
pp. 1591-1600 ◽  
Author(s):  
Maria L. Ribeiro ◽  
Andras I. Seres ◽  
Angela M. Carneiro ◽  
Michael Stur ◽  
Alain Zourdani ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blind Study ◽  
Double Blind Study ◽  
Calcium Dobesilate ◽  
Double Blind

A Double-Blind Out-Patient Trial of Indalpine vs Mianserin

1985 ◽  
Vol 147 (3) ◽  
pp. 306-309 ◽  
Author(s):  
G. J. Naylor ◽  
B. Martin
Keyword(s):  
Side Effects ◽  
Treated Group ◽  
Blind Study ◽  
Antidepressant Effect ◽  
Double Blind Study ◽  
Double Blind ◽  
Significant Difference

SummaryIndalpine 150 mg per day and mianserin 60 mg per day were compared in a double-blind study of 65 depressed out-patients: 52 patients completed the 4-week trial. At the end of four weeks there was no significant difference in antidepressant effect between the two drugs; but in the first two weeks, improvement in the mianserin-treated group was significantly greater than that in the indalpine group. The mianserin-treated group reported more side-effects of sedation (eg. drowsiness, clumsiness, heaviness of limbs etc.) and one patient on indalpine developed a mild leucopenia.

scholarly journals Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1445
Author(s):  
Iselin Vildmyren ◽  
Alfred Halstensen ◽  
Adrian McCann ◽  
Øivind Midttun ◽  
Per Magne Ueland ◽  
...  
Keyword(s):  
Health Effects ◽  
Plasma Concentrations ◽  
Protein Supplementation ◽  
Blind Study ◽  
Control Group ◽  
Human Consumption ◽  
Double Blind Study ◽  
Double Blind ◽  
Potential Health ◽  
Residual Protein

Large quantities of protein-rich cod residuals, which are currently discarded, could be utilized for human consumption. Although fish fillet intake is related to beneficial health effects, little is known about the potential health effects of consuming cod residual protein powder. Fifty lean adults were randomized to consume capsules with 8.1 g/day of cod residual protein (Cod-RP) or placebo capsules (Control group) for eight weeks, in this randomized, double-blind study. The intervention was completed by 40 participants. Fasting glucose and insulin concentrations were unaffected by Cod-RP supplementation, whereas plasma concentrations of α-hydroxybutyrate, β-hydroxybutyrate and acetoacetate all were decreased compared with the Control group. Trimethylamine N-oxide concentration in plasma and urine were increased in the Cod-RP group compared with the Control group. To conclude, the reduction in these potential early markers of impaired glucose metabolism following Cod-RP supplementation may indicate beneficial glucoregulatory effects of cod residual proteins. Trimethylamine N-oxide appears to be an appropriate biomarker of cod residual protein intake in lean adults.

A Controlled Comparison of Fluoxetine and Amitriptyline in Depressed Out-patients

1987 ◽  
Vol 151 (3) ◽  
pp. 337-340 ◽  
Author(s):  
J. P. R. Young ◽  
A. Coleman ◽  
M. H. Lader
Keyword(s):  
Sleep Disturbances ◽  
Treated Group ◽  
Blind Study ◽  
Serotonin Uptake ◽  
Dry Mouth ◽  
Selective Serotonin ◽  
Double Blind Study ◽  
Double Blind ◽  
Uptake Inhibitor ◽  
Serotonin Uptake Inhibitor

Fluoxetine, a selective serotonin uptake inhibitor (mean dose 73 mg each morning) was compared with amitriptyline (mean dose 122 mg at night) in a double-blind study of 64 depressed out-patients. Fifty patients completed the 6-week trial. The drugs did not differ with respect to psychiatrists' ratings, but amitriptyline was slightly superior with respect to patients' ratings. The amitriptyline-treated group had complaints of dry mouth and dizziness on standing; the fluoxetine-treated group of sleep disturbances, nausea, and headaches.

scholarly journals Soft Tissue Wound Healing by Laser

2018 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Pressure Ulcers ◽  
Monochromatic Light ◽  
Placebo Treatment ◽  
Treated Group ◽  
Healing Time ◽  
Blind Study ◽  
Controlled Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Ulcer Area

Background: In 1967 a few years after the first working laser was invented, Endre Mester in Semmelweis University Budapest, Hungary wanted to find out if laser might cause cancer. He took some mice, shaved the hair off their backs, divided them into two groups and gave a laser treatment with a low powered ruby laser to one group. They did not get cancer and to his surprise the hair on the treated group grew back more quickly than the untreated group. That was how “laser biostimulation” effects were discovered. (Effect of laser on hair Growth of mice (in Hungarian). Mester, E. Szende, B. and Tota, J.G. (1967). Kiserl Orvostud 19. 628- 631). Purpose of the work: The effects of pulsed monochromatic light, with fixed pulsations and wavelengths, on the healing of pressure ulcers were evaluated in this prospective, randomized, controlled study. Method: A placebo-controlled, double-blind study using low energy photon therapy (LLLT) was performed in ten patients with bedsore on the back. Treatment was given three times a week for 10 weeks, using monochromatic (red) optical sources; diode 660nm (GaAl- 660). The patients who were randomized to placebo treatment received sham therapy from an identicalappearing light source from the same delivery system. Results: Ten patients with bedsore were randomized to receive LLLT or placebo therapy. At the conclusion of the study, the percentage of the initial ulcer area remaining unhealed in the LLLT and placebo groups was 24.4% and 84.7%, respectively (P = 0.0008). The decrease in ulcer area (compared to baseline) observed in the LLLT and placebo groups was 193.0 mm2 and 14.7 mm2, respectively (P = 0.0002). One patient dropped out of the study, complaining of lack of treatment efficacy; he was found to be randomized to the placebo group. There were no adverse effects. Conclusions: In this placebo-controlled, double-blind study LLLT was an effective modality for the treatment of bedsore which were resistant to conventional medical management. The results are encouraging as pulsed monochromatic light increased healing rate and shortened healing time. This will positively affect the quality of life in elderly patients with pressure ulcers.

The Antenatal Use of Betamethasone in the Prevention of Respiratory Distress Syndrome: A Controlled Double-Blind Study

PEDIATRICS ◽  
1979 ◽  
Vol 63 (1) ◽  
pp. 73-79
Author(s):  
Apostolos N. Papageorgiou ◽  
Marie F. Desgranges ◽  
Michel Masson ◽  
Eleanor Colle ◽  
Richard Shatz ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Premature Infants ◽  
Death Rate ◽  
Distress Syndrome ◽  
Protective Role ◽  
Blind Study ◽  
Control Group ◽  
Double Blind Study ◽  
Double Blind

One hundred forty-six pregnant women were enrolled in a prospective double-blind study to assess the effectiveness and side-effects of antenatal administration of betamethasone in the prevention of respiratory distress syndrome (RDS) in potentially premature infants. On admission to the study, the women were given, at random, either 12 mg of betamethasone or placebo. The same dose was repeated 24 hours later and then weekly up to 34 weeks of gestation. Gestational age of the infants ranged from 25 to 34 weeks, and birth weights ranged between 730 and 2,650 gm. Statistically significant differences in favor of the infants in the betamethasone group were found in the incidence of RDS, 20.7 in the betamethasone group compared with 59.5% in the control group (P &lt; .005); in the severity of RDS (P &lt; .05); and in the death rate (P &lt; .05). A higher incidence of hypoglycemia was found among infants in the betamethasone group (P &lt; .05). Prolonged rupture of the membranes played no protective role against RDS, and the incidence of infection was similar in both groups.

Treatment of Thrombosis of the Central Retinal Vein with Streptokinase

1968 ◽  
Vol 20 (03/04) ◽  
pp. 415-419 ◽  
Author(s):  
G. J. H den Ottolander ◽  
A Craandijk
Keyword(s):  
Visual Acuity ◽  
Treated Group ◽  
Heparin Therapy ◽  
Blind Study ◽  
Fluorescence Angiography ◽  
Double Blind Study ◽  
Double Blind ◽  
Streptokinase Therapy ◽  
Central Retinal Vein ◽  
Retinal Vein Occlusions

SummaryIn a double blind study of 5 heparin treated and 5 streptokinase treated patients with central retinal vein occlusions it would seem from the results based on visual acuity, ERG and EOG and fluorescence angiography that the heparin treated group were better off than the SK treated patients.It therefore seems dubious whether streptokinase therapy affords such an important advantage over the convential heparin therapy in cases of central retinal vein occlusions. It must be stressed that a group of 10 patients is very small and that the observations made are probably not statistically significant.

scholarly journals Paranasal sinus air suction for immediate pain relief of acute migraine – a randomized, double blind pilot study

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
S. M. R. Bandara ◽  
S. Samita ◽  
A. M. Kiridana ◽  
D. M. P. U. K. Ralapanawa ◽  
H. M. M. T. B. Herath
Keyword(s):  
Pain Relief ◽  
Paranasal Sinus ◽  
Rating Scale ◽  
International Headache Society ◽  
Treated Group ◽  
Control Group ◽  
Double Blind Study ◽  
Airflow Rate ◽  
Acute Migraine ◽  
Double Blind

Abstract Background Migraine is a primary headache disorder, which cause significant disability in adolescence. This double blind, randomized clinical trial assessed the immediate effects of suction of paranasal sinus air during an acute migraine episode. Methods A randomized, double blind study was conducted with 56 selected Sri Lankan school children of 16–19 years of age. Participants who met International Headache Society criteria for migraine (with or without aura) were included in the study. Subjects were randomly allocated into 2 groups where one group was subjected to three intermittent 10 sec paranasal air suctions with a ten sec suction free interval between two suctions for each nostril and the other group was subjected to placebo air suction (no paranasal air suction) in similar arrangement. Severity of headache and sub–orbital tenderness before and after suction were recorded using standard pain rating scale. Results After dropouts, treated and placebo groups consisted of 27 and 23 subjects respectively. The mean headache pain score drop in the treated group was significantly higher compared to that of the control group. Moreover, there was a difference in the treatment response between the types of headache (with or without aura). With respect to tenderness there was a statistically significant drop in the treated group compared to the control. In general, airflow rates in left and right nostrils were different in these subjects. However such difference was not seen in the tenderness on two sides. Nevertheless it was revealed that airflow rate has a slight negative correlation with the tenderness irrespective of the side. Conclusion Sixty–second paranasal air suction can provide an immediate pain relief for acute migraine in adolescents. We did not assess pain outcomes beyond 60 s, but the initial responses suggests the need to further study the efficacy of paranasal suction in migraine. A further study is suggested to evaluate the acute effects, efficacy and side effects of paranasal air suction using follow up over a prolong period. Trial registration Sri Lanka Clinical Trials Registry SLCTR/2017/018, 29 Jun 2017. Retrospectively registered.

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