scholarly journals Medical relevance of UK-funded non-human primate research published from January 1997 to July 2012

2014 ◽  
Vol 107 (7) ◽  
pp. 264-270 ◽  
Author(s):  
Edward Moore
Keyword(s):  
Primate Research ◽  
Medical Relevance ◽  
Human Primate

scholarly journals Genetic diversity of Klebsiella pneumoniae isolates during an outbreak in a non-human primate research colony

2016 ◽  
Vol 45 (6) ◽  
pp. 312-317 ◽  
Author(s):  
Alfonso S. Gozalo ◽  
William R. Elkins ◽  
Lynn E. Lambert ◽  
Frida Stock ◽  
Marvin L. Thomas ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Klebsiella Pneumoniae ◽  
Primate Research ◽  
Human Primate

scholarly journals High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA

2021 ◽  
Vol 15 (3) ◽  
pp. e0009141
Author(s):  
Angel M. Padilla ◽  
Phil Y. Yao ◽  
Tre J. Landry ◽  
Gretchen M. Cooley ◽  
Susan M. Mahaney ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Immune Responses ◽  
Host Species ◽  
The United States ◽  
Minimum Length ◽  
Primate Research ◽  
Infection Dynamics ◽  
Natural Host Species ◽  
The Usa ◽  
Human Primate

Trypanosoma cruzi, the causative agent of human Chagas disease, is endemic to the southern region of the United States where it routinely infects many host species. The indoor/outdoor housing configuration used in many non-human primate research and breeding facilities in the southern of the USA provides the opportunity for infection by T. cruzi and thus provides source material for in-depth investigation of host and parasite dynamics in a natural host species under highly controlled and restricted conditions. For cynomolgus macaques housed at such a facility, we used a combination of serial blood quantitative PCR (qPCR) and hemoculture to confirm infection in >92% of seropositive animals, although each method alone failed to detect infection in >20% of cases. Parasite isolates obtained from 43 of the 64 seropositive macaques were of 2 broad genetic types (discrete typing units, (DTU’s) I and IV); both within and between these DTU groupings, isolates displayed a wide variation in growth characteristics and virulence, elicited host immune responses, and susceptibility to drug treatment in a mouse model. Likewise, the macaques displayed a diversity in T cell and antibody response profiles that rarely correlated with parasite DTU type, minimum length of infection, or age of the primate. This study reveals the complexity of infection dynamics, parasite phenotypes, and immune response patterns that can occur in a primate group, despite being housed in a uniform environment at a single location, and the limited time period over which the T. cruzi infections were established.

scholarly journals Applying the 3Rs to non-human primate research: Barriers and solutions

2017 ◽  
Vol 23 ◽  
pp. 51-56 ◽  
Author(s):  
Mark J. Prescott ◽  
Jan A. Langermans ◽  
Ian Ragan
Keyword(s):  
Primate Research ◽  
Human Primate

scholarly journals Idiopathic chronic diarrhea in rhesus macaques is not associated with enteric viral infections

2021 ◽  
Author(s):  
Eric Delwart ◽  
Michael J Tisza ◽  
Eda Altan ◽  
Yanpeng Li ◽  
Xutao Deng ◽  
...  
Keyword(s):  
Rhesus Macaque ◽  
Viral Infections ◽  
Chronic Diarrhea ◽  
Rhesus Macaques ◽  
Viral Metagenomics ◽  
Primate Research ◽  
Healthy Controls ◽  
Viral Loads ◽  
Common Causes ◽  
Human Primate

While recent changes in treatment have reduced the lethality of idiopathic chronic diarrhea (ICD), this condition remains one of the most common causes of rhesus macaque deaths in non-human primate research centers. We compared the eukaryotic viromes in fecal swabs from 52 animals with ICD and 41 healthy animals. Viral metagenomics targeting virus-like particles was used to identify viruses shed by each animal. Five viruses belonging to the Picornaviridae, one to the Caliciviridae, one to the Parvoviridae, and one to the Adenoviridae families were identified. The fraction of reads matching each viral species was then used to estimate and compare viral loads in ICD cases versus healthy controls. None of the eukaryotic viruses detected in fecal swabs were strongly associated with ICD. Other potential causes of ICD are discussed.

Do we need non-human primate research?

2012 ◽  
Vol 46 (3) ◽  
pp. 177-177 ◽  
Author(s):  
Beat M Riederer
Keyword(s):  
Primate Research ◽  
Human Primate

The ethical justification for the use of non-human primates in research: the Weatherall report revisited

2017 ◽  
Vol 44 (5) ◽  
pp. 328-331 ◽  
Author(s):  
Gardar Arnason
Keyword(s):  
Animal Rights ◽  
Animal Research ◽  
Primate Research ◽  
Ethical Justification ◽  
Academic Literature ◽  
Ethical Discussion ◽  
Academic Discussion ◽  
Human Primate ◽  
Social Level

The Weatherall report on the use of non-human primates in research was published in 2006. Its main conclusion was that there is a strong scientific case for the use of non-human primates in some cases, but the report stressed the importance of evaluating each case in the light of the availability of alternatives. In addition to arguing for the scientific necessity of using non-human primates in research, the report also provided an ethical justification. As could be expected, the report was harshly criticised by animal rights groups, but in the academic literature, only two critical replies appeared. In what follows, I will describe the ethical justification for non-human primate research as it is laid out in the Weatherall report and then consider the criticism in the academic literature. I conclude that the report’s ethical justification for the use of non-human primates in research, in particular in basic neuroscientific research, has not been convincingly challenged by its critics. Since the criticism of the report is limited and represents only a small part of the academic discussion about the use of non-human primates in research, and a still smaller part of the ethical discussion about animal research, it is important that the discussion continue both at the academic and social level.

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