Comorbid Somatic Symptoms and Functional Status in Patients With Fibromyalgia and Chronic Fatigue Syndrome: Sensory Amplification as a Common Mechanism

2008 ◽  
Vol 49 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Michael E. Geisser ◽  
Cathy Strader Donnell ◽  
Frank Petzke ◽  
Richard H. Gracely ◽  
Daniel J. Clauw ◽  
...  
2015 ◽  
Vol 48 (5) ◽  
pp. 278-286 ◽  
Author(s):  
Stefan M. van Geelen ◽  
Coralie E. Fuchs ◽  
Rolf van Geel ◽  
Patrick Luyten ◽  
Elise M. van de Putte

2002 ◽  
Vol 32 (6) ◽  
pp. 1075-1089 ◽  
Author(s):  
M. C. ARNOLD ◽  
D. A. PAPANICOLAOU ◽  
J. A. O'GRADY ◽  
A. LOTSIKAS ◽  
J. K. DALE ◽  
...  

Background. Individuals with acute infections experience a range of symptoms including fatigue, malaise, muscle aches, and difficulties with concentration and memory that are usually self-limited. This cluster of symptoms is otherwise, similar to those that characterize chronic fatigue syndrome (CFS). The goal of the present study was to evaluate the cognitive and psychological functioning of CFS patients and normal controls (NCs) when they both were experiencing acute influenza-like symptoms. To induce influenza-like symptoms, we administered interleukin-6 (IL-6), a cytokine that temporarily activates the acute phase immunological and endocrine responses.Methods. Nineteen patients who met the 1994 International CFS Study Group Criteria and ten normal controls (NCs) completed routine clinical evaluations, neuropsychological tests of short-term memory, selective attention, and executive control, and self-ratings of somatic symptoms and psychological mood before, shortly following, and 1 day after IL-6 administration.Results. CFS patients consistently reported more somatic symptoms, even when both groups perceived that they were ill. Both groups somatic symptoms increased during the IL-6 challenge, but the CFS patients symptoms increased more rapidly than controls. In general, the CFS patients performed similarly to NCs on the cognitive measures before, during, and after the IL-6. In contrast to predictions, IL-6 provocation did not impair the cognitive performance of either CFS patients or NCs.Conclusions. The IL-6 provocation exacerbated the patients self-reported symptoms but did not reveal notable cognitive impairments between patients and controls during cytokine-induced acute influenza-like symptoms.


2002 ◽  
Vol 53 (6) ◽  
pp. 1097-1106 ◽  
Author(s):  
Suzanne S Taillefer ◽  
Laurence J Kirmayer ◽  
James M Robbins ◽  
Jean-Claude Lasry

2003 ◽  
Vol 191 (5) ◽  
pp. 324-331 ◽  
Author(s):  
LANA A. TIERSKY ◽  
ROBERT J. MATHEIS ◽  
JOHN DELUCA ◽  
GUDRUN LANGE ◽  
BENJAMIN H. NATELSON

1996 ◽  
Vol 101 (4) ◽  
pp. 364-370 ◽  
Author(s):  
Dedra Buchwald ◽  
Tsilke Pearlman ◽  
Jovine Umali ◽  
Karen Schmaling ◽  
Wayne Katon

2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Luis C Nacul ◽  
Eliana M Lacerda ◽  
Peter Campion ◽  
Derek Pheby ◽  
Maria de L Drachler ◽  
...  

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