scholarly journals Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget’s disease of bone

2000 ◽  
Vol 105 (12) ◽  
pp. 1833-1838 ◽  
Author(s):  
Cheikh Menaa ◽  
Sakamuri V. Reddy ◽  
Noriyoshi Kurihara ◽  
Hidefumi Maeda ◽  
Dirk Anderson ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Rank Ligand ◽  
Paget's Disease Of Bone ◽  
Ligand Expression ◽  
Marrow Cells

scholarly journals FGF-2 Stimulation of RANK Ligand Expression in Paget’s Disease of Bone

2009 ◽  
Vol 94 (8) ◽  
pp. 3100-3100
Author(s):  
Kumaran Sundaram ◽  
Joseph Senn ◽  
Sambandam Yuvaraj ◽  
D. Sudhaker Rao ◽  
Sakamuri V. Reddy
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Rank Ligand ◽  
Paget's Disease Of Bone ◽  
Ligand Expression ◽  
Stimulation Of

scholarly journals CXCL5 stimulation of RANK ligand expression in Paget’s disease of bone

2013 ◽  
Vol 93 (4) ◽  
pp. 472-479 ◽  
Author(s):  
Kumaran Sundaram ◽  
D Sudhaker Rao ◽  
William L Ries ◽  
Sakamuri V Reddy
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Rank Ligand ◽  
Paget's Disease Of Bone ◽  
Ligand Expression ◽  
Stimulation Of

Bone Marrow Scintigraphy in Paget's Disease of Bone

1990 ◽  
Vol 31 (2) ◽  
pp. 141-144 ◽  
Author(s):  
Ulf Rudberg ◽  
S.-O. Ahlbäck ◽  
R. Udén
Keyword(s):  
Bone Marrow ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Bone Marrow Scintigraphy

scholarly journals Failure to Detect Measles Virus Ribonucleic Acid in Bone Cells from Patients with Paget’s Disease

2008 ◽  
Vol 93 (4) ◽  
pp. 1398-1401 ◽  
Author(s):  
Brya G. Matthews ◽  
Muhammad A. Afzal ◽  
Philip D. Minor ◽  
Usha Bava ◽  
Karen E. Callon ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Measles Virus ◽  
Bone Cells ◽  
Bone Marrow Cells ◽  
Subacute Sclerosing Panencephalitis ◽  
Paget’S Disease ◽  
Pcr Amplification ◽  
Positive Control ◽  
Paget's Disease ◽  
Marrow Cells

Abstract Background: Paget’s disease is a condition of focal accelerated bone turnover. Electron-microscopy investigations of osteoclasts from pagetic lesions have identified nuclear inclusion bodies that have a similar appearance to viral nucleocapsid particles. Subsequently, RNA from several paramyxoviruses has been detected in pagetic tissue, and it was suggested that these viruses, in particular measles, might play a role in the etiology of Paget’s disease. We have tested for measles virus sequences in osteoblasts and bone marrow cells collected from pagetic lesions and healthy bone. Methods: Bone and bone marrow samples were taken from Paget’s patients and control subjects, and cells were cultured from each of these tissues. RNA was extracted from 13 osteoblast cultures and 13 cultures of bone marrow cells derived from pagetic lesions, and from 26 and 23 control osteoblast and bone marrow cultures, respectively. These samples were sourced from 22 patients with Paget’s disease and 31 controls. RT-PCR-nested PCR amplification was used for the detection of the genes for the measles nucleocapsid and matrix proteins. Results: Measles virus sequences were not detected in any of the pagetic or control samples. However, measles virus sequences were identified in samples of a measles virus culture isolate included as a positive control, and in a brain sample from a patient with subacute sclerosing panencephalitis, a condition associated with chronic measles infection. Conclusion: The results of the study do not support the hypothesis that measles virus plays a role in the pathogenesis of Paget’s disease.

Paget's Disease of Bone

2006 ◽  
Vol 39 (11) ◽  
pp. 20
Author(s):  
Elizabeth Mechcatie ◽  
Lora T. McGlade
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone

Variants in RIN3 predispose to Paget's disease of bone

2014 ◽  
Author(s):  
Maheva Vallet ◽  
Antonia Sophocleous ◽  
Jon Warner ◽  
Stewart W Morris ◽  
James F Wilson ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone
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