Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer

Todd W. Miller; Bryan T. Hennessy; Ana M. González-Angulo; Emily M. Fox; Gordon B. Mills; Heidi Chen; Catherine Higham; Carlos García-Echeverría; Yu Shyr; Carlos L. Arteaga

doi:10.1172/jci41680

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer

Journal of Clinical Investigation ◽

10.1172/jci41680 ◽

2010 ◽

Vol 120 (7) ◽

pp. 2406-2413 ◽

Cited By ~ 313

Author(s):

Todd W. Miller ◽

Bryan T. Hennessy ◽

Ana M. González-Angulo ◽

Emily M. Fox ◽

Gordon B. Mills ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Human Breast Cancer ◽

Human Breast ◽

Phosphatidylinositol 3 Kinase ◽

Hormone Dependence ◽

Estrogen Receptor Positive ◽

Phosphatidylinositol 3

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Estrogen and TCDD Influence RLN2 Gene Activity in Estrogen Receptor-Positive Human Breast Cancer Cells

Annals of the New York Academy of Sciences ◽

10.1111/j.1749-6632.2009.03836.x ◽

2009 ◽

Vol 1160 (1) ◽

pp. 367-373 ◽

Cited By ~ 9

Author(s):

Silke Kietz ◽

Shu Feng ◽

Alexander Agoulnik ◽

Sabine Hombach-Klonisch

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Gene Activity ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Estrogen Receptor Positive

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Lycium BarbarumInhibits Growth of Estrogen Receptor Positive Human Breast Cancer Cells by Favorably Altering Estradiol Metabolism

Nutrition and Cancer ◽

10.1080/01635580802585952 ◽

2009 ◽

Vol 61 (3) ◽

pp. 408-414 ◽

Cited By ~ 23

Author(s):

Go Li ◽

Daniel W. Sepkovic ◽

H. Leon Bradlow ◽

Nitin T. Telang ◽

George Y. C. Wong

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Estrogen Receptor Positive ◽

Estradiol Metabolism

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Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen

Cancer Letters ◽

10.1016/s0304-3835(96)04557-0 ◽

1997 ◽

Vol 112 (2) ◽

pp. 127-133 ◽

Cited By ~ 180

Author(s):

Felicia V. So ◽

Najla Guthrie ◽

Ann F. Chambers ◽

Kenneth K. Carroll

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Inhibition Of Proliferation ◽

Estrogen Receptor Positive ◽

Mcf 7

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Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer

Breast Cancer Research ◽

10.1186/bcr2833 ◽

2011 ◽

Vol 13 (2) ◽

Cited By ~ 125

Author(s):

Cesar G Sanchez ◽

Cynthia X Ma ◽

Robert J Crowder ◽

Therese Guintoli ◽

Chanpheng Phommaly ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Endocrine Therapy ◽

Phosphatidylinositol 3 Kinase ◽

Kinase Inhibition ◽

Estrogen Receptor Positive ◽

Positive Breast Cancer ◽

Phosphatidylinositol 3

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The kinome associated with estrogen receptor-positive status in human breast cancer

Endocrine Related Cancer ◽

10.1530/erc-14-0232 ◽

2014 ◽

Vol 21 (5) ◽

pp. R357-R370 ◽

Cited By ~ 4

Author(s):

M. C. Bruce ◽

D. McAllister ◽

L. C. Murphy

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Human Breast Cancer ◽

Human Breast ◽

Estrogen Receptor Positive

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Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer

International Journal of Cancer ◽

10.1002/ijc.10147 ◽

2002 ◽

Vol 98 (1) ◽

pp. 148-154 ◽

Cited By ~ 47

Author(s):

Baljinder Salh ◽

Anthony Marotta ◽

Ravenska Wagey ◽

Mohamed Sayed ◽

Steven Pelech

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Human Breast ◽

Phosphatidylinositol 3 Kinase ◽

Downstream Effectors ◽

Phosphatidylinositol 3

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Profiling of gene expression regulated by 17β-estradiol and tamoxifen in estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines

Breast Cancer Targets and Therapy ◽

10.2147/bctt.s146247 ◽

2017 ◽

Vol Volume 9 ◽

pp. 537-550 ◽

Cited By ~ 2

Author(s):

Nelson Rangel ◽

Victoria Villegas ◽

Milena Rondon-Lagos

Keyword(s):

Breast Cancer ◽

Gene Expression ◽

Estrogen Receptor ◽

Breast Cancer Cell ◽

Human Breast Cancer ◽

Human Breast Cancer Cell ◽

Breast Cancer Cell Lines ◽

Human Breast ◽

Estrogen Receptor Positive ◽

Estrogen Receptor Negative

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Identification of Potential Glycoprotein Biomarkers in Estrogen Receptor Positive (ER+) and Negative (ER-) Human Breast Cancer Tissues by LC-LTQ/FT-ICR Mass Spectrometry

Journal of Cancer ◽

10.7150/jca.4592 ◽

2012 ◽

Vol 3 ◽

pp. 269-284 ◽

Cited By ~ 11

Author(s):

Suzan M. Semaan ◽

Xu Wang ◽

Alan G. Marshall ◽

Qing-Xiang Amy Sang

Keyword(s):

Breast Cancer ◽

Mass Spectrometry ◽

Estrogen Receptor ◽

Human Breast Cancer ◽

Human Breast ◽

Estrogen Receptor Positive ◽

Cancer Tissues ◽

Ft Icr

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Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells

Cell Death and Disease ◽

10.1038/cddis.2012.179 ◽

2012 ◽

Vol 3 (12) ◽

pp. e440-e440 ◽

Cited By ~ 5

Author(s):

V Folgiero ◽

S E Di Carlo ◽

G Bon ◽

E P Spugnini ◽

A Di Benedetto ◽

...

Keyword(s):

Breast Cancer ◽

Antitumor Activity ◽

Cancer Cells ◽

Human Breast Cancer ◽

Breast Cancer Cells ◽

Catalytic Subunit ◽

Human Breast Cancer Cells ◽

Human Breast ◽

Phosphatidylinositol 3 Kinase ◽

Phosphatidylinositol 3

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BreastDefend Enhances Effect of Tamoxifen in Estrogen Receptor-positive Human Breast Cancer in Vitro and in Vivo

10.28991/iccr-2019-008 ◽

2019 ◽

Author(s):

Isaac Eliaz ◽

Dan Sliva

Keyword(s):

Breast Cancer ◽

Estrogen Receptor ◽

Human Breast Cancer ◽

Human Breast ◽

Estrogen Receptor Positive

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