scholarly journals Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair

2003 ◽  
Vol 112 (11) ◽  
pp. 1751-1761 ◽  
Author(s):  
Myriam Alcalay ◽  
Natalia Meani ◽  
Vania Gelmetti ◽  
Anna Fantozzi ◽  
Marta Fagioli ◽  
...  
Keyword(s):  
Dna Repair ◽  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Fusion Proteins ◽  
Myeloid Leukemia ◽  
Stem Cell Maintenance ◽  
Cell Maintenance ◽  
Acute Myeloid

scholarly journals Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia

2019 ◽  
Vol 110 (7) ◽  
pp. 2200-2210 ◽  
Author(s):  
Yajing Chu ◽  
Yangpeng Chen ◽  
Mengke Li ◽  
Deyang Shi ◽  
Bichen Wang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Myeloid Leukemia ◽  
Leukemia Stem Cell ◽  
Stem Cell Maintenance ◽  
Cell Maintenance ◽  
Acute Myeloid

scholarly journals Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance

2019 ◽  
Vol 79 (22) ◽  
pp. 5799-5811 ◽  
Author(s):  
Michelle Ly ◽  
Stefan Rentas ◽  
Ana Vujovic ◽  
Nicholas Wong ◽  
Steven Moreira ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Myeloid Leukemia ◽  
Leukemia Stem Cell ◽  
Stem Cell Maintenance ◽  
Human Acute Myeloid Leukemia ◽  
Cell Maintenance ◽  
Acute Myeloid

CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia

Leukemia ◽  
2014 ◽  
Vol 29 (3) ◽  
pp. 625-635 ◽  
Author(s):  
P M Korthuis ◽  
G Berger ◽  
B Bakker ◽  
M Rozenveld-Geugien ◽  
J Jaques ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Myeloid Leukemia ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance ◽  
Acute Myeloid

scholarly journals Targeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Lianjun Zhang ◽  
Le Xuan Truong Nguyen ◽  
Ying-Chieh Chen ◽  
Dijiong Wu ◽  
Guerry J. Cook ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Myeloid Leukemia ◽  
Fusion Gene ◽  
Leukemia Stem Cell ◽  
Stem Cell Maintenance ◽  
Xenograft Models ◽  
Leukemia Development ◽  
Genetic Deletion ◽  
Acute Myeloid

AbstractAcute myeloid leukemia (AML) harboring inv(16)(p13q22) expresses high levels of miR-126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 expression through aberrant miR-126 transcription and perturbed miR-126 biogenesis via the HDAC8/RAN-XPO5-RCC1 axis. Aberrant miR-126 upregulation promotes survival of leukemia-initiating progenitors and is critical for initiating and maintaining CM-driven AML. We show that miR-126 enhances MYC activity through the SPRED1/PLK2-ERK-MYC axis. Notably, genetic deletion of miR-126 significantly reduces AML rate and extends survival in CM knock-in mice. Therapeutic depletion of miR-126 with an anti-miR-126 (miRisten) inhibits AML cell survival, reduces leukemia burden and leukemia stem cell (LSC) activity in inv(16) AML murine and xenograft models. The combination of miRisten with chemotherapy further enhances the anti-leukemia and anti-LSC activity. Overall, this study provides molecular insights for the mechanism and impact of miR-126 dysregulation in leukemogenesis and highlights the potential of miR-126 depletion as a therapeutic approach for inv(16) AML.

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