CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia

Leukemia ◽  
2014 ◽  
Vol 29 (3) ◽  
pp. 625-635 ◽  
Author(s):  
P M Korthuis ◽  
G Berger ◽  
B Bakker ◽  
M Rozenveld-Geugien ◽  
J Jaques ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Myeloid Leukemia ◽  
Hematopoietic Stem ◽  
Stem Cell Maintenance ◽  
Cell Maintenance ◽  
Acute Myeloid

scholarly journals Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

2020 ◽  
Author(s):  
Linus Angenendt ◽  
Isabel Hilgefort ◽  
Jan-Henrik Mikesch ◽  
Bernhard Schlüter ◽  
Wolfgang E. Berdel ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Myeloid Leukemia ◽  
Epstein Barr Virus Infection ◽  
Hematopoietic Stem ◽  
Acute Myeloid

AbstractLow intake of magnesium has been associated with the occurrence of lymphomas and decreased magnesium levels suppress the cytotoxic function of T cells and natural killer cells in patients with “X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia” (XMEN) syndrome. These cell types are also important mediators of immune-mediated effects after allogeneic hematopoietic stem cell transplantation. Here, we show that high posttransplant magnesium levels independently associate with a lower incidence of relapse, a higher risk of acute graft-versus-host disease, and a higher non-relapse mortality in 368 patients with acute myeloid leukemia from our center. Magnesium serum levels might impact on donor-cell-mediated immune responses in acute myeloid leukemia.

scholarly journals Reduced hematopoietic stem cell frequency predicts outcome in acute myeloid leukemia

Haematologica ◽  
2017 ◽  
Vol 102 (9) ◽  
pp. 1567-1577 ◽  
Author(s):  
Wenwen Wang ◽  
Thomas Stiehl ◽  
Simon Raffel ◽  
Van T. Hoang ◽  
Isabel Hoffmann ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Hematopoietic Stem Cell ◽  
Myeloid Leukemia ◽  
Cell Frequency ◽  
Hematopoietic Stem ◽  
Acute Myeloid
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