scholarly journals Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress

2020 ◽  
Vol 130 (7) ◽  
pp. 3576-3591 ◽  
Author(s):  
Irma Tindemans ◽  
Anne van Schoonhoven ◽  
Alex KleinJan ◽  
Marjolein J.W. de Bruijn ◽  
Melanie Lukkes ◽  
...  
Keyword(s):  
Lymph Node ◽  
Notch Signaling ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell

scholarly journals Multi-Faceted Notch in Allergic Airway Inflammation

2019 ◽  
Vol 20 (14) ◽  
pp. 3508
Author(s):  
Miao-Tzu Huang ◽  
Chiao-Juno Chiu ◽  
Bor-Luen Chiang
Keyword(s):  
Embryonic Development ◽  
Notch Signaling ◽  
Airway Inflammation ◽  
Cell Activity ◽  
Adult Life ◽  
Allergic Airway Inflammation ◽  
T Cell Subsets ◽  
Cell Fate Decisions ◽  
Physiological Processes

Notch is an evolutionarily conserved signaling family which iteratively exerts pleiotropic functions in cell fate decisions and various physiological processes, not only during embryonic development but also throughout adult life. In the context of the respiratory system, Notch has been shown to regulate ciliated versus secretory lineage differentiation of epithelial progenitor cells and coordinate morphogenesis of the developing lung. Reminiscent of its role in development, the Notch signaling pathway also plays a role in repair of lung injuries by regulation of stem cell activity, cell differentiation, cell proliferation and apoptosis. In addition to functions in embryonic development, cell and tissue renewal and various physiological processes, including glucose and lipid metabolism, Notch signaling has been demonstrated to regulate differentiation of literally almost all T-cell subsets, and impact on elicitation of inflammatory response and its outcome. We have investigated the role of Notch in allergic airway inflammation in both acute and chronic settings. In this mini-review, we will summarize our own work and recent advances on the role of Notch signaling in allergic airway inflammation, and discuss potential applications of the Notch signaling family in therapy for allergic airway diseases.

IL-25 enhances allergic airway inflammation by amplifying a TH2 cell–dependent pathway in mice

2006 ◽  
Vol 118 (3) ◽  
pp. 606-614 ◽  
Author(s):  
T TAMACHI ◽  
Y MAEZAWA ◽  
K IKEDA ◽  
S KAGAMI ◽  
M HATANO ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell ◽  
Dependent Pathway

scholarly journals Indispensable Role of Stat5a in Stat6-Independent Th2 Cell Differentiation and Allergic Airway Inflammation

2005 ◽  
Vol 174 (6) ◽  
pp. 3734-3740 ◽  
Author(s):  
Hiroaki Takatori ◽  
Hiroshi Nakajima ◽  
Koichi Hirose ◽  
Shin-ichiro Kagami ◽  
Tomohiro Tamachi ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell

Allergic airway inflammation: key players beyond the Th2 cell pathway

2017 ◽  
Vol 278 (1) ◽  
pp. 145-161 ◽  
Author(s):  
Koichi Hirose ◽  
Arifumi Iwata ◽  
Tomohiro Tamachi ◽  
Hiroshi Nakajima
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell ◽  
Key Players

Role of IgE in Th2 Cell-Mediated Allergic Airway Inflammation

2003 ◽  
Vol 131 (Suppl. 1) ◽  
pp. 2-6 ◽  
Author(s):  
Yuko Maezawa ◽  
Hiroshi Nakajima ◽  
Kotaro Kumano ◽  
Shuichi Kubo ◽  
Hajime Karasuyama ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell

Th2-Cell-Mediated Chemokine Synthesis Is Involved in Allergic Airway Inflammation in Mice

2006 ◽  
Vol 140 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Akio Mori ◽  
Koji Ogawa ◽  
Yuichiro Kajiyama ◽  
Matsunobu Suko ◽  
Osamu Kaminuma
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell

scholarly journals Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable

2017 ◽  
Vol 140 (4) ◽  
pp. 1079-1089 ◽  
Author(s):  
Irma Tindemans ◽  
Melanie Lukkes ◽  
Marjolein J.W. de Bruijn ◽  
Bobby W.S. Li ◽  
Menno van Nimwegen ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Notch Signaling ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Notch Ligands

scholarly journals Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation

2018 ◽  
Vol 49 (1) ◽  
pp. 92-107 ◽  
Author(s):  
Jun-Qi Yang ◽  
Khalid W. Kalim ◽  
Yuan Li ◽  
Xin Duan ◽  
Phuong Nguyen ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell
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