Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators

2018 ◽  
Vol 211 ◽  
pp. 78-88 ◽  
Author(s):  
Jin Mi Chun ◽  
A. Reum Lee ◽  
Hyo Seon Kim ◽  
A. Yeong Lee ◽  
Gyo Jeong Gu ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Inflammatory Mediators ◽  
Cell Activation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell

IL-25 enhances allergic airway inflammation by amplifying a TH2 cell–dependent pathway in mice

2006 ◽  
Vol 118 (3) ◽  
pp. 606-614 ◽  
Author(s):  
T TAMACHI ◽  
Y MAEZAWA ◽  
K IKEDA ◽  
S KAGAMI ◽  
M HATANO ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell ◽  
Dependent Pathway

scholarly journals Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress

2020 ◽  
Vol 130 (7) ◽  
pp. 3576-3591 ◽  
Author(s):  
Irma Tindemans ◽  
Anne van Schoonhoven ◽  
Alex KleinJan ◽  
Marjolein J.W. de Bruijn ◽  
Melanie Lukkes ◽  
...  
Keyword(s):  
Lymph Node ◽  
Notch Signaling ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell

Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma

2011 ◽  
Vol 301 (6) ◽  
pp. L975-L984 ◽  
Author(s):  
Guqin Zhang ◽  
Hanxiang Nie ◽  
Jiong Yang ◽  
Xuhong Ding ◽  
Yi Huang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Airway Inflammation ◽  
Cell Activation ◽  
Cell Function ◽  
Allergic Airway Inflammation ◽  
Nkt Cells ◽  
Chronic Inflammatory Disease ◽  
Type I ◽  
Type Ii ◽  
Nkt Cell

Asthma is a common chronic inflammatory disease involving many different cell types. Recently, type I natural killer T (NKT) cells have been demonstrated to play a crucial role in the development of asthma. However, the roles of type II NKT cells in asthma have not been investigated before. Interestingly, type I and type II NKT cells have been shown to have opposing roles in antitumor immunity, antiparasite immunity, and autoimmunity. We hypothesized that sulfatide-activated type II NKT cells could prevent allergic airway inflammation by inhibiting type I NKT cell function in asthma. Strikingly, in our mouse model, activation of type II NKT cells by sulfatide administration and adoptive transfer of sulfatide-activated type II NKT cells result in reduced-inflammation cell infiltration in the lung and bronchoalveolar lavage fluid, decreased levels of IL-4 and IL-5 in the BALF; and decreased serum levels of ovalbumin-specific IgE and IgG1. Furthermore, it is found that the activation of sulfatide-reactive type II NKT cells leads to the functional inactivation of type I NKT cells, including the proliferation and cytokine secretion. Our data reveal that type II NKT cells activated by glycolipids, such as sulfatide, may serve as a novel approach to treat allergic diseases and other disorders characterized by inappropriate type I NKT cell activation.

Preventive Intra Oral Treatment of Sea Cucumber Ameliorate OVA-Induced Allergic Airway Inflammation

2016 ◽  
Vol 44 (08) ◽  
pp. 1663-1674 ◽  
Author(s):  
Da-In Lee ◽  
Mi-Kyung Park ◽  
Shin Ae Kang ◽  
Jun-Ho Choi ◽  
Seok-Jung Kang ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Sea Cucumber ◽  
Cell Activation ◽  
Biological Effects ◽  
Oral Treatment ◽  
Allergic Airway Inflammation ◽  
Treg Cells ◽  
Mesenteric Lymph Nodes ◽  
Anti Cancer ◽  
Anti Oxidant

Sea cucumber extracts have potent biological effects, including anti-viral, anti-cancer, antibacterial, anti-oxidant, and anti-inflammation effects. To understand their anti-asthma effects, we induced allergic airway inflammation in mice after 7 oral administrations of the extract. The hyper-responsiveness value in mice with ovalbumin (OVA)-alum-induced asthma after oral injection of sea cucumber extracts was significantly lower than that in the OVA-alum-induced asthma group. In addition, the number of eosinophils in the lungs of asthma-induced mice pre-treated with sea cucumber extract was significantly decreased compared to that of PBS pre-treated mice. Additionally, CD4[Formula: see text]CD25[Formula: see text]Foxp3[Formula: see text]T (regulatory T; Treg) cells significantly increased in mesenteric lymph nodes after 7 administrations of the extract. These results suggest that sea cucumber extract can ameliorate allergic airway inflammation via Treg cell activation and recruitment to the lung.

scholarly journals Indispensable Role of Stat5a in Stat6-Independent Th2 Cell Differentiation and Allergic Airway Inflammation

2005 ◽  
Vol 174 (6) ◽  
pp. 3734-3740 ◽  
Author(s):  
Hiroaki Takatori ◽  
Hiroshi Nakajima ◽  
Koichi Hirose ◽  
Shin-ichiro Kagami ◽  
Tomohiro Tamachi ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell

Allergic airway inflammation: key players beyond the Th2 cell pathway

2017 ◽  
Vol 278 (1) ◽  
pp. 145-161 ◽  
Author(s):  
Koichi Hirose ◽  
Arifumi Iwata ◽  
Tomohiro Tamachi ◽  
Hiroshi Nakajima
Keyword(s):  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Th2 Cell ◽  
Key Players

Effects of ZCR-2060 on Allergic Airway Inflammation and Cell Activation in Guinea-pigs

1994 ◽  
Vol 46 (11) ◽  
pp. 876-882 ◽  
Author(s):  
Tooru Abe ◽  
Kenji Yoshida ◽  
Takeshi Omata ◽  
Yoshihide Segawa ◽  
Kazuo Matsuda ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Guinea Pigs ◽  
Cell Activation ◽  
Allergic Airway Inflammation
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